Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTZJRL0)

• DTT Name: Gamma-glutamyl hydrolase (GGH)
• Synonyms: Human glutamyl hydrolase; Gamma-Glu-X carboxypeptidase; GGH; Conjugase
• Gene Name: GGH
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Peptidase
• UniProt ID: GGH_HUMAN
• TTD ID: T71646
• EC Number: EC 3.4.19.9
• Sequence:
  MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASY
  VKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQ
  SFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTE
  LLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYG
  VQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQF
  SPIYTGNISSFQQCYIFD
• Function: Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability ofdietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
• KEGG Pathway:
  Folate biosynthesis (hsa00790)
  Biosynthesis of cofactors (hsa01240)
  Antifolate resistance (hsa01523)
• Reactome Pathway: Neutrophil degranulation (R-HSA-6798695)

The Drug-Metabolizing Enzyme (DME) Role of This DTT

• DTT DME Name: Gamma-Glu-X carboxypeptidase (GGH) DME Info
• Gene Name: GGH

2 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[2]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[3]

References

• [1] Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
• [2] Optimization of the trienzyme extraction for the microbiological assay of folate in vegetables. J Agric Food Chem. 2007 May 16;55(10):3884-8.
• [3] The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4.