Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTZT9R2)

DTT Name Hydroxysteroid dehydrogenase 3-beta (HSD3B)
Synonyms 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
Gene Name HSD3B1
DTT Type
Literature-reported target
 [1]
BioChemical Class
Short-chain dehydrogenases reductase
UniProt ID
3BHS1_HUMAN ; 3BHS2_HUMAN
TTD ID
T40628
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELREEFSKLQNKTKLTVLE
GDILDEPFLKRACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVF
IYTSSIEVAGPNSYKEIIQNGHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGGTL
YTCALRPMYIYGEGSRFLSASINEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALRAL
QDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRLDSRWSFPLSLMYWIGFLLEI
VSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEWVGSL
VDRHKETLKSKTQ
Function
Catalyzes the biosynthesis of the steroid progesterone from pregnenolone, 17-hydroxyprogesterone from 17-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone (DHEA) in the adrenal gland. Also catalyzes the oxidative conversion of 5-3-hydroxysteroids to the 4-3-keto configuration and is, therefore, essential for the biosynthesis of all classes of hormonal steroids, namely progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens.
KEGG Pathway
Steroid hormone biosynthesis (hsa00140 )
Metabolic pathways (hsa01100 )
Ovarian steroidogenesis (hsa04913 )
Aldosterone synthesis and secretion (hsa04925 )
Cortisol synthesis and secretion (hsa04927 )
Cushing syndrome (hsa04934 )
Reactome Pathway
Mineralocorticoid biosynthesis (R-HSA-193993 )
Glucocorticoid biosynthesis (R-HSA-194002 )
Androgen biosynthesis (R-HSA-193048 )
BioCyc Pathway
MetaCyc:HS08829-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
7 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
17 beta-N,N-diethylcarbamoyl-4-aza-5 alpha-androstan-3-one (4MA) DMDR1M6 Discovery agent N.A. Investigative [1]
2-Sulfhydryl-Ethanol DMJBO3D Discovery agent N.A. Investigative [2]
4-ANDROSTENE-3-17-DIONE DMSE8NU Discovery agent N.A. Investigative [2]
4-MA DMNCVIP Discovery agent N.A. Investigative [3]
5alpha-Androstan-3,17-Dione DMHI7Y2 Discovery agent N.A. Investigative [2]
Epostane DMV8PB4 Abortion JA00 Investigative [4]
Equilenin DMHO56W Discovery agent N.A. Investigative [2]
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⏷ Show the Full List of 7 Investigative Drug(s)

References

1 Inhibition of 3 beta-hydroxysteroid-dehydrogenase: an approach for prostate cancer treatment Anticancer Res. 1995 Jul-Aug;15(4):1349-54.
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 Activity and inhibition of 3-beta-hydroxysteroid dehydrogenase/delta-5-4-isomerase in human skin. Skin Pharmacol. 1997;10(3):160-8.
4 Termination of early pregnancy by the 3 beta-hydroxysteroid dehydrogenase inhibitor epostane. N Engl J Med. 1988 Sep 29;319(13):813-7.