Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DE3FYEM)

• DME Name: Calcidiol 1-monooxygenase (CYP27B1) DME Info
• Gene Name: CYP27B1

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	1.08E-28	2.68E-01	1.22E+00
Alopecia	ED70	Skin from scalp	9.67E-06	-5.46E-01	-9.39E-01
Alzheimer's disease	8A20	Entorhinal cortex	1.57E-01	-3.94E-02	-2.13E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	1.30E-01	-5.01E-01	-6.40E-01
Aortic stenosis	BB70	Calcified aortic valve	3.18E-01	1.83E-01	2.96E-01
Apnea	7A40	Hyperplastic tonsil	4.79E-01	-2.17E-01	-3.99E-01
Arthropathy	FA00-FA5Z	Peripheral blood	3.98E-01	6.50E-02	3.59E-01
Asthma	CA23	Nasal and bronchial airway	9.73E-06	2.25E-01	3.23E-01
Atopic dermatitis	EA80	Skin	7.55E-09	5.85E-01	1.61E+00
Autism	6A02	Whole blood	2.67E-01	-8.10E-02	-3.75E-01
Autoimmune uveitis	9A96	Peripheral monocyte	2.59E-01	-1.06E-01	-6.80E-01
Autosomal dominant monocytopenia	4B04	Whole blood	2.80E-01	7.59E-02	6.46E-01
Bacterial infection of gingival	1C1H	Gingival tissue	6.72E-02	1.95E-01	5.31E-01
Batten disease	5C56.1	Whole blood	9.57E-01	5.35E-02	3.42E-01
Behcet's disease	4A62	Peripheral blood	8.10E-01	-3.48E-02	-1.33E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	1.06E-01	-1.03E-01	-6.47E-01
Bladder cancer	2C94	Bladder tissue	2.77E-10	1.70E+00	6.98E+00
Breast cancer	2C60-2C6Z	Breast tissue	1.39E-25	2.49E-01	4.70E-01
Cardioembolic stroke	8B11.20	Whole blood	4.45E-01	3.87E-02	9.26E-02
Cervical cancer	2C77	Cervical tissue	1.20E-06	4.45E-01	1.51E+00
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	7.97E-01	-1.33E-02	-1.04E-01
Chronic hepatitis C	1E51.1	Whole blood	7.52E-01	-1.79E-02	-6.45E-02
Chronic obstructive pulmonary disease	CA22	Lung tissue	8.15E-02	1.42E-01	3.50E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	7.02E-01	-2.06E-02	-9.39E-02
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	1.19E-01	9.73E-02	8.52E-01
Colon cancer	2B90	Colon tissue	1.83E-86	8.07E-01	2.55E+00
Coronary artery disease	BA80-BA8Z	Peripheral blood	8.98E-02	7.84E-02	6.67E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	6.98E-01	2.77E-02	4.68E-02
Endometriosis	GA10	Endometrium tissue	7.72E-01	5.68E-02	7.11E-02
Familial hypercholesterolemia	5C80.00	Peripheral blood	9.48E-01	7.54E-02	4.03E-01
Familial hypercholesterolemia	5C80.00	Whole blood	1.87E-03	-4.28E-01	-1.26E+00
Gastric cancer	2B72	Gastric tissue	5.94E-02	3.32E-01	1.57E+00
Glioblastopma	2A00.00	Nervous tissue	8.42E-37	2.67E-01	7.74E-01
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	1.16E-01	1.19E-01	1.54E+00
Glioma	2A00.0Y-2A00.0Z	White matter tissue	7.77E-07	1.68E+00	2.33E+00
Head and neck cancer	2D42	Head and neck tissue	2.01E-43	1.32E+00	5.01E+00
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	1.47E-01	-3.73E-02	-1.77E-01
Huntington's disease	8A01.10	Whole blood	5.10E-01	4.31E-02	3.57E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	8.81E-01	1.61E-02	6.26E-02
Immunodeficiency	4A00-4A20	Peripheral blood	4.92E-01	-5.23E-02	-4.56E-01
Influenza	1E30	Whole blood	7.61E-02	-2.30E+00	-2.25E+00
Interstitial cystitis	GC00.3	Bladder tissue	8.48E-02	1.49E-01	1.59E+00
Intracranial aneurysm	8B01.0	Intracranial artery	6.77E-03	6.01E-01	1.08E+00
Irritable bowel syndrome	DD91.0	Rectal colon tissue	1.05E-03	1.75E-01	4.57E-01
Ischemic stroke	8B11	Peripheral blood	1.63E-01	8.20E-02	3.12E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	4.38E-01	1.92E-02	4.72E-02
Lateral sclerosis	8B60.4	Skin	1.19E-01	7.63E-02	5.17E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	5.43E-01	7.34E-02	3.28E-01
Liver cancer	2C12.0	Liver tissue	6.10E-06	1.08E-01	3.52E-01
Liver failure	DB99.7-DB99.8	Liver tissue	2.54E-01	1.69E-01	8.02E-01
Lung cancer	2C25	Lung tissue	8.48E-88	1.10E+00	2.28E+00
Lupus erythematosus	4A40	Whole blood	1.43E-03	-2.29E-01	-4.02E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	4.45E-01	-7.39E-02	-4.36E-01
Major depressive disorder	6A70-6A7Z	Whole blood	9.18E-01	-5.12E-02	-1.50E-01
Melanoma	2C30	Skin	1.89E-01	2.94E-01	2.61E-01
Multiple myeloma	2A83.1	Peripheral blood	5.78E-02	9.32E-02	3.37E-01
Multiple myeloma	2A83.1	Bone marrow	4.28E-03	1.81E-01	1.01E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	8.13E-01	3.88E-02	1.09E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	6.75E-01	3.81E-02	7.59E-02
Myelofibrosis	2A20.2	Whole blood	1.21E-01	6.20E-02	3.88E-01
Myocardial infarction	BA41-BA50	Peripheral blood	4.33E-01	1.78E-01	2.11E-01
Myopathy	8C70.6	Muscle tissue	9.16E-01	-4.89E-02	-3.32E-01
Neonatal sepsis	KA60	Whole blood	3.64E-02	-9.13E-02	-4.18E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	1.94E-03	-6.47E-01	-1.41E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	1.24E-01	1.57E-01	1.20E+00
Obesity related type 2 diabetes	5A11	Omental adipose tissue	9.12E-01	-1.41E-01	-2.10E-01
Olive pollen allergy	CA08.00	Peripheral blood	8.99E-02	-1.53E+00	-1.73E+00
Oral cancer	2B6E	Oral tissue	4.30E-19	1.80E+00	3.49E+00
Osteoarthritis	FA00-FA0Z	Synovial tissue	1.20E-01	4.57E-01	1.22E+00
Osteoporosis	FB83.1	Bone marrow	5.74E-01	2.85E-01	6.30E-01
Ovarian cancer	2C73	Ovarian tissue	2.09E-02	6.81E-02	2.37E-01
Pancreatic cancer	2C10	Pancreas	1.40E-02	-7.45E-01	-1.19E+00
Parkinson's disease	8A00.0	Substantia nigra tissue	5.05E-02	4.64E-02	3.16E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	7.65E-01	2.41E-02	1.41E-01
Pituitary cancer	2D12	Pituitary tissue	5.70E-01	-2.32E-02	-4.53E-02
Pituitary gonadotrope tumour	2D12	Pituitary tissue	7.52E-01	1.24E-01	2.06E-01
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	9.57E-01	4.71E-02	2.09E-01
Polycythemia vera	2A20.4	Whole blood	4.42E-06	1.42E-01	8.23E-01
Pompe disease	5C51.3	Biceps muscle	2.75E-02	-1.49E-01	-6.18E-01
Preterm birth	KA21.4Z	Myometrium	1.62E-01	-2.39E-01	-1.93E-01
Prostate cancer	2C82	Prostate	8.48E-02	-6.84E-01	-9.36E-01
Psoriasis	EA90	Skin	4.57E-12	6.11E-01	9.76E-01
Rectal cancer	2B92	Rectal colon tissue	6.55E-03	4.75E-01	1.73E+00
Renal cancer	2C90-2C91	Kidney	2.93E-02	-1.75E+00	-9.36E-01
Retinoblastoma	2D02.2	Uvea	6.76E-06	-1.58E+00	-2.14E+00
Rheumatoid arthritis	FA20	Synovial tissue	9.78E-06	9.57E-01	4.07E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	7.67E-03	5.17E-02	3.15E-01
Schizophrenia	6A20	Prefrontal cortex	9.14E-01	-2.65E-02	-6.31E-02
Schizophrenia	6A20	Superior temporal cortex	5.58E-01	-1.58E-02	-9.56E-02
Scleroderma	4A42.Z	Whole blood	2.84E-05	3.21E-01	2.56E+00
Seizure	8A60-8A6Z	Whole blood	8.62E-01	2.21E-02	1.09E-01
Sensitive skin	EK0Z	Skin	9.45E-01	3.40E-02	9.71E-02
Sepsis with septic shock	1G41	Whole blood	5.04E-01	2.66E-03	1.25E-02
Shwachman-Diamond syndrome	3A70.0	Bone marrow	3.44E-01	4.96E-01	7.78E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	5.61E-01	-3.13E-02	-2.00E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	1.84E-02	2.89E-01	2.50E+00
Sjogren's syndrome	4A43.2	Salivary gland tissue	7.71E-01	1.19E-02	1.41E-01
Skin cancer	2C30-2C3Z	Skin	1.43E-25	7.66E-01	1.13E+00
Thrombocythemia	3B63	Whole blood	1.49E-03	1.84E-01	1.03E+00
Thrombocytopenia	3B64	Whole blood	1.32E-01	7.44E-01	1.80E+00
Thyroid cancer	2D10	Thyroid	5.63E-10	-7.59E-01	-8.38E-01
Tibial muscular dystrophy	8C75	Muscle tissue	6.00E-01	1.27E-04	7.66E-04
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	5.90E-03	3.62E-01	2.80E+00
Type 2 diabetes	5A11	Liver tissue	5.90E-01	6.18E-02	1.85E-01
Ureter cancer	2C92	Urothelium	2.27E-01	-9.77E-02	-3.80E-01
Uterine cancer	2C78	Endometrium tissue	3.05E-03	5.25E-02	9.69E-02
Vitiligo	ED63.0	Skin	1.44E-02	5.54E-01	1.41E+00