Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DE3Z1RA)

• DME Name: Pyridoxamine-phosphate oxidase (PNPO) DME Info
• Gene Name: PNPO

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	5.78E-02	1.75E-01	4.09E-01
Alopecia	ED70	Skin from scalp	1.20E-04	1.61E-01	6.59E-01
Alzheimer's disease	8A20	Entorhinal cortex	2.99E-02	-1.61E-01	-6.72E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	2.11E-01	2.15E-01	8.12E-01
Aortic stenosis	BB70	Calcified aortic valve	5.78E-01	-9.93E-03	-2.59E-02
Apnea	7A40	Hyperplastic tonsil	9.66E-02	-2.25E-01	-5.70E-01
Arthropathy	FA00-FA5Z	Peripheral blood	3.18E-01	-2.20E-01	-9.02E-01
Asthma	CA23	Nasal and bronchial airway	3.84E-08	3.19E-01	5.31E-01
Atopic dermatitis	EA80	Skin	4.19E-05	3.30E-01	2.40E+00
Autism	6A02	Whole blood	2.79E-01	-1.59E-01	-7.54E-01
Autoimmune uveitis	9A96	Peripheral monocyte	3.66E-01	-1.36E-01	-5.96E-01
Autosomal dominant monocytopenia	4B04	Whole blood	5.77E-01	-5.55E-02	-3.15E-01
Bacterial infection of gingival	1C1H	Gingival tissue	8.96E-02	-5.48E-02	-2.53E-01
Batten disease	5C56.1	Whole blood	2.73E-01	1.54E-02	1.40E-01
Behcet's disease	4A62	Peripheral blood	9.79E-01	-1.03E-02	-5.20E-02
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	5.42E-01	5.50E-03	4.57E-02
Bladder cancer	2C94	Bladder tissue	8.56E-05	4.91E-01	3.51E+00
Breast cancer	2C60-2C6Z	Breast tissue	5.08E-06	1.18E-01	3.29E-01
Cardioembolic stroke	8B11.20	Whole blood	8.24E-01	-1.98E-02	-1.02E-01
Cervical cancer	2C77	Cervical tissue	4.17E-03	-2.42E-01	-7.93E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	1.58E-01	3.01E-01	5.14E-01
Chronic hepatitis C	1E51.1	Whole blood	6.09E-01	2.14E-02	8.08E-02
Chronic obstructive pulmonary disease	CA22	Lung tissue	5.46E-01	-5.53E-02	-2.11E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	2.66E-01	-1.17E-02	-4.91E-02
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	7.98E-01	1.77E-03	9.20E-03
Colon cancer	2B90	Colon tissue	3.68E-49	5.77E-01	1.78E+00
Coronary artery disease	BA80-BA8Z	Peripheral blood	7.36E-01	1.61E-01	4.99E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	7.09E-01	-8.34E-02	-2.21E-01
Endometriosis	GA10	Endometrium tissue	1.83E-04	-2.91E-01	-1.17E+00
Familial hypercholesterolemia	5C80.00	Peripheral blood	6.48E-01	4.71E-02	2.38E-01
Familial hypercholesterolemia	5C80.00	Whole blood	2.78E-03	2.79E-01	1.52E+00
Gastric cancer	2B72	Gastric tissue	9.75E-02	7.20E-01	1.44E+00
Glioblastopma	2A00.00	Nervous tissue	4.24E-04	1.05E-01	3.01E-01
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	1.94E-03	-2.98E-01	-2.89E+01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	2.42E-02	4.52E-01	9.33E-01
Head and neck cancer	2D42	Head and neck tissue	1.18E-02	6.97E-02	2.83E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	9.66E-01	2.93E-02	8.21E-02
Huntington's disease	8A01.10	Whole blood	1.93E-01	-7.53E-02	-4.53E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	1.29E-02	5.78E-01	2.11E+00
Immunodeficiency	4A00-4A20	Peripheral blood	1.65E-05	3.31E-01	5.49E+00
Influenza	1E30	Whole blood	6.95E-03	-3.24E-01	-2.69E+00
Interstitial cystitis	GC00.3	Bladder tissue	2.35E-02	-2.16E-01	-1.59E+00
Intracranial aneurysm	8B01.0	Intracranial artery	7.52E-09	6.34E-01	4.40E+00
Irritable bowel syndrome	DD91.0	Rectal colon tissue	3.98E-01	1.59E-03	5.00E-03
Ischemic stroke	8B11	Peripheral blood	4.51E-01	-1.09E-01	-4.45E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	2.30E-09	-1.68E-01	-7.35E-01
Lateral sclerosis	8B60.4	Skin	3.48E-02	6.52E-01	1.97E+00
Lateral sclerosis	8B60.4	Cervical spinal cord	1.93E-01	4.93E-02	1.91E-01
Liver cancer	2C12.0	Liver tissue	8.63E-09	-3.69E-01	-1.00E+00
Liver failure	DB99.7-DB99.8	Liver tissue	3.17E-04	-1.22E+00	-5.61E+00
Lung cancer	2C25	Lung tissue	2.21E-34	2.99E-01	1.12E+00
Lupus erythematosus	4A40	Whole blood	3.31E-01	1.24E-01	2.70E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	8.43E-01	1.66E-02	1.43E-01
Major depressive disorder	6A70-6A7Z	Whole blood	9.76E-01	1.35E-02	6.62E-02
Melanoma	2C30	Skin	2.01E-01	-7.39E-02	-1.16E-01
Multiple myeloma	2A83.1	Peripheral blood	6.74E-01	-7.33E-02	-1.65E-01
Multiple myeloma	2A83.1	Bone marrow	1.05E-04	7.75E-01	2.53E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	2.69E-01	-1.02E-01	-2.56E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	6.73E-03	2.59E-01	5.41E-01
Myelofibrosis	2A20.2	Whole blood	8.91E-01	4.75E-02	5.46E-01
Myocardial infarction	BA41-BA50	Peripheral blood	8.39E-04	-2.34E-01	-4.15E-01
Myopathy	8C70.6	Muscle tissue	4.50E-01	-4.07E-02	-1.99E-01
Neonatal sepsis	KA60	Whole blood	1.11E-15	-3.56E-01	-1.60E+00
Neuroectodermal tumour	2A00.11	Brain stem tissue	8.59E-01	1.21E-01	3.84E-01
Non-alcoholic fatty liver disease	DB92	Liver tissue	4.55E-01	-1.77E-01	-6.28E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	2.90E-01	1.82E-01	6.35E-01
Olive pollen allergy	CA08.00	Peripheral blood	6.49E-01	1.07E-01	4.20E-01
Oral cancer	2B6E	Oral tissue	3.54E-02	1.58E-01	3.60E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	2.08E-01	3.71E-01	7.45E-01
Osteoporosis	FB83.1	Bone marrow	3.52E-01	-1.11E-01	-2.91E-01
Ovarian cancer	2C73	Ovarian tissue	9.53E-04	8.56E-01	1.89E+00
Pancreatic cancer	2C10	Pancreas	2.77E-02	8.17E-02	3.57E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	1.31E-01	-3.14E-01	-7.20E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	6.37E-01	3.26E-02	2.15E-01
Pituitary cancer	2D12	Pituitary tissue	1.60E-03	4.53E-01	1.46E+00
Pituitary gonadotrope tumour	2D12	Pituitary tissue	1.17E-01	2.07E-01	6.51E-01
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	8.35E-02	7.72E-02	5.00E-01
Polycythemia vera	2A20.4	Whole blood	1.09E-01	-6.79E-02	-7.05E-01
Pompe disease	5C51.3	Biceps muscle	4.46E-04	-5.23E-01	-2.39E+00
Preterm birth	KA21.4Z	Myometrium	3.22E-01	-1.39E-01	-4.45E-01
Prostate cancer	2C82	Prostate	4.77E-06	1.06E+00	2.19E+00
Psoriasis	EA90	Skin	4.27E-33	5.82E-01	2.29E+00
Rectal cancer	2B92	Rectal colon tissue	1.26E-02	2.43E-01	1.29E+00
Renal cancer	2C90-2C91	Kidney	1.31E-01	-4.83E-01	-7.35E-01
Retinoblastoma	2D02.2	Uvea	3.16E-12	1.07E+00	6.06E+00
Rheumatoid arthritis	FA20	Synovial tissue	1.12E-03	5.03E-01	2.04E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	1.38E-01	-4.98E-02	-4.71E-01
Schizophrenia	6A20	Prefrontal cortex	1.53E-03	-9.68E-02	-4.95E-01
Schizophrenia	6A20	Superior temporal cortex	3.28E-01	-4.93E-02	-3.19E-01
Scleroderma	4A42.Z	Whole blood	6.23E-01	-2.73E-02	-1.84E-01
Seizure	8A60-8A6Z	Whole blood	2.45E-01	-7.88E-02	-3.25E-01
Sensitive skin	EK0Z	Skin	7.48E-01	2.05E-02	1.69E-01
Sepsis with septic shock	1G41	Whole blood	8.04E-45	-3.51E-01	-1.93E+00
Shwachman-Diamond syndrome	3A70.0	Bone marrow	2.15E-01	-7.28E-02	-7.23E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	8.67E-01	-3.15E-02	-1.60E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	4.97E-01	-3.44E-01	-7.91E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	2.06E-01	-1.51E-02	-1.13E-01
Skin cancer	2C30-2C3Z	Skin	1.82E-15	4.98E-01	1.01E+00
Thrombocythemia	3B63	Whole blood	8.20E-01	-1.11E-02	-1.35E-01
Thrombocytopenia	3B64	Whole blood	5.77E-01	3.13E-01	4.33E-01
Thyroid cancer	2D10	Thyroid	4.95E-16	-4.06E-01	-1.27E+00
Tibial muscular dystrophy	8C75	Muscle tissue	1.19E-06	-5.04E-01	-2.61E+00
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	5.48E-01	2.93E-02	1.18E-01
Type 2 diabetes	5A11	Liver tissue	5.20E-01	-1.25E-01	-6.52E-01
Ureter cancer	2C92	Urothelium	3.48E-01	6.55E-02	5.73E-01
Uterine cancer	2C78	Endometrium tissue	2.07E-02	-2.22E-01	-3.48E-01
Vitiligo	ED63.0	Skin	7.06E-01	5.87E-02	6.14E-01