Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DE87OZS)

• DME Name: Arachidonate 5-lipoxygenase (ALOX5) DME Info
• Gene Name: ALOX5

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	7.95E-43	-1.65E+00	-1.80E+00
Alopecia	ED70	Skin from scalp	7.26E-05	2.53E-01	1.00E+00
Alzheimer's disease	8A20	Entorhinal cortex	5.43E-08	4.11E-01	8.14E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	6.26E-01	-2.39E-02	-4.28E-02
Aortic stenosis	BB70	Calcified aortic valve	8.28E-03	2.57E-01	7.96E-01
Apnea	7A40	Hyperplastic tonsil	9.02E-01	-3.33E-02	-1.68E-01
Arthropathy	FA00-FA5Z	Peripheral blood	6.70E-02	4.60E-01	1.17E+00
Asthma	CA23	Nasal and bronchial airway	9.43E-03	1.39E-01	2.81E-01
Atopic dermatitis	EA80	Skin	2.96E-03	-2.18E-01	-7.78E-01
Autism	6A02	Whole blood	3.86E-01	1.51E-01	1.98E-01
Autoimmune uveitis	9A96	Peripheral monocyte	4.91E-01	-6.12E-01	-9.77E-01
Autosomal dominant monocytopenia	4B04	Whole blood	3.78E-01	-4.94E-01	-6.40E-01
Bacterial infection of gingival	1C1H	Gingival tissue	1.45E-19	7.07E-01	1.93E+00
Batten disease	5C56.1	Whole blood	8.24E-01	-1.21E-01	-2.96E-01
Behcet's disease	4A62	Peripheral blood	8.84E-01	-8.44E-02	-2.14E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	2.41E-02	-9.26E-02	-5.68E-01
Bladder cancer	2C94	Bladder tissue	1.26E-04	-2.03E+00	-3.53E+00
Breast cancer	2C60-2C6Z	Breast tissue	3.82E-06	1.20E-01	2.65E-01
Cardioembolic stroke	8B11.20	Whole blood	4.50E-03	2.82E-01	7.00E-01
Cervical cancer	2C77	Cervical tissue	7.96E-02	8.87E-02	2.76E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	6.54E-01	1.23E-01	9.17E-02
Chronic hepatitis C	1E51.1	Whole blood	9.93E-01	-1.79E-01	-2.67E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	7.42E-01	-1.76E-01	-2.47E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	1.25E-03	4.34E-01	6.27E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	6.44E-03	1.65E-01	2.33E+00
Colon cancer	2B90	Colon tissue	4.80E-04	-2.22E-01	-7.13E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	3.33E-01	-3.46E-02	-7.57E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	9.25E-01	6.32E-01	6.20E-01
Endometriosis	GA10	Endometrium tissue	2.47E-02	4.32E-01	9.21E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	4.99E-01	-1.06E-01	-2.43E-01
Familial hypercholesterolemia	5C80.00	Whole blood	6.44E-03	1.60E-01	4.33E-01
Gastric cancer	2B72	Gastric tissue	1.90E-01	2.12E-01	7.81E-01
Glioblastopma	2A00.00	Nervous tissue	2.58E-15	2.27E-01	4.11E-01
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	8.08E-01	-5.05E-02	-1.64E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	2.57E-01	-2.44E-01	-3.60E-01
Head and neck cancer	2D42	Head and neck tissue	2.59E-04	2.64E-01	5.51E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	3.53E-01	3.50E-02	1.53E-01
Huntington's disease	8A01.10	Whole blood	2.32E-01	4.90E-02	7.85E-02
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	2.82E-01	3.47E-01	7.97E-01
Immunodeficiency	4A00-4A20	Peripheral blood	1.72E-01	-1.38E-01	-5.76E-01
Influenza	1E30	Whole blood	1.28E-01	8.66E-01	2.13E+00
Interstitial cystitis	GC00.3	Bladder tissue	2.42E-04	-1.77E+00	-3.90E+00
Intracranial aneurysm	8B01.0	Intracranial artery	2.08E-04	1.15E+00	4.55E+00
Irritable bowel syndrome	DD91.0	Rectal colon tissue	5.51E-01	1.19E-02	4.25E-02
Ischemic stroke	8B11	Peripheral blood	3.90E-01	-8.64E-02	-1.87E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	7.42E-01	-1.37E-01	-1.90E-01
Lateral sclerosis	8B60.4	Skin	7.15E-01	5.00E-02	1.99E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	2.94E-02	1.47E-01	1.04E+00
Liver cancer	2C12.0	Liver tissue	1.16E-04	-3.31E-01	-8.31E-01
Liver failure	DB99.7-DB99.8	Liver tissue	5.69E-04	3.24E-01	2.33E+00
Lung cancer	2C25	Lung tissue	6.11E-92	-1.84E+00	-2.66E+00
Lupus erythematosus	4A40	Whole blood	1.98E-09	5.97E-01	7.20E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	8.98E-01	-3.80E-02	-1.95E-01
Major depressive disorder	6A70-6A7Z	Whole blood	1.42E-01	1.22E-01	2.89E-01
Melanoma	2C30	Skin	5.11E-01	8.43E-02	1.20E-01
Multiple myeloma	2A83.1	Peripheral blood	8.93E-01	-1.22E-02	-8.03E-02
Multiple myeloma	2A83.1	Bone marrow	2.08E-05	7.64E-01	3.50E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	3.99E-01	1.30E-01	5.13E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	2.37E-01	-3.39E-02	-1.06E-01
Myelofibrosis	2A20.2	Whole blood	1.36E-05	-9.02E-01	-2.55E+00
Myocardial infarction	BA41-BA50	Peripheral blood	3.16E-04	6.19E-01	1.01E+00
Myopathy	8C70.6	Muscle tissue	3.08E-03	6.09E-01	1.70E+00
Neonatal sepsis	KA60	Whole blood	3.46E-35	1.80E+00	2.37E+00
Neuroectodermal tumour	2A00.11	Brain stem tissue	1.75E-04	-9.12E-01	-2.21E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	1.74E-01	3.89E-01	1.55E+00
Obesity related type 2 diabetes	5A11	Omental adipose tissue	9.93E-01	7.03E-02	4.12E-01
Olive pollen allergy	CA08.00	Peripheral blood	6.98E-02	1.63E-01	1.17E+00
Oral cancer	2B6E	Oral tissue	9.36E-02	-1.05E-01	-3.35E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	3.25E-01	-2.61E-01	-4.66E-01
Osteoporosis	FB83.1	Bone marrow	5.34E-02	2.91E-01	2.07E+00
Ovarian cancer	2C73	Ovarian tissue	3.87E-04	1.14E+00	2.04E+00
Pancreatic cancer	2C10	Pancreas	1.34E-04	9.01E-01	1.52E+00
Parkinson's disease	8A00.0	Substantia nigra tissue	4.65E-01	3.64E-01	1.07E+00
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	4.79E-04	3.87E-01	8.58E-01
Pituitary cancer	2D12	Pituitary tissue	3.13E-01	3.32E-01	7.47E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	3.32E-01	2.12E-01	4.79E-01
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	1.63E-01	1.73E-01	7.03E-01
Polycythemia vera	2A20.4	Whole blood	1.11E-02	-2.49E-01	-6.71E-01
Pompe disease	5C51.3	Biceps muscle	6.79E-01	3.41E-03	2.28E-02
Preterm birth	KA21.4Z	Myometrium	8.12E-01	-3.01E-01	-5.05E-01
Prostate cancer	2C82	Prostate	4.15E-01	-6.25E-02	-1.48E-01
Psoriasis	EA90	Skin	5.19E-01	-4.92E-03	-1.45E-02
Rectal cancer	2B92	Rectal colon tissue	5.52E-01	-1.57E-01	-7.67E-01
Renal cancer	2C90-2C91	Kidney	1.02E-04	1.48E+00	2.24E+00
Retinoblastoma	2D02.2	Uvea	1.45E-04	9.11E-01	4.70E+00
Rheumatoid arthritis	FA20	Synovial tissue	1.00E-02	5.46E-01	2.11E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	2.94E-01	-2.27E-02	-1.19E-01
Schizophrenia	6A20	Prefrontal cortex	5.52E-02	1.87E-01	1.18E-01
Schizophrenia	6A20	Superior temporal cortex	7.34E-03	3.50E-01	1.17E+00
Scleroderma	4A42.Z	Whole blood	7.86E-02	-2.56E-01	-9.70E-01
Seizure	8A60-8A6Z	Whole blood	6.89E-01	-5.01E-02	-7.89E-02
Sensitive skin	EK0Z	Skin	8.61E-01	7.61E-02	3.78E-01
Sepsis with septic shock	1G41	Whole blood	6.22E-64	1.69E+00	2.27E+00
Shwachman-Diamond syndrome	3A70.0	Bone marrow	4.47E-02	-3.40E-01	-1.04E+00
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	8.02E-01	1.22E-01	5.14E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	4.57E-01	9.13E-02	7.89E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	1.29E-01	4.07E-02	2.11E-01
Skin cancer	2C30-2C3Z	Skin	4.58E-05	-3.14E-01	-8.71E-01
Thrombocythemia	3B63	Whole blood	1.14E-05	-6.94E-01	-1.94E+00
Thrombocytopenia	3B64	Whole blood	1.60E-01	4.81E-01	6.34E-01
Thyroid cancer	2D10	Thyroid	6.80E-29	1.51E+00	2.10E+00
Tibial muscular dystrophy	8C75	Muscle tissue	1.33E-05	5.01E-01	1.76E+00
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	5.17E-01	1.10E-01	6.58E-01
Type 2 diabetes	5A11	Liver tissue	6.81E-01	1.13E-01	4.94E-01
Ureter cancer	2C92	Urothelium	9.19E-01	-1.32E-03	-5.71E-03
Uterine cancer	2C78	Endometrium tissue	8.34E-02	-3.69E-02	-7.20E-02
Vitiligo	ED63.0	Skin	4.69E-01	-1.12E-02	-3.24E-02