Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DEKP5HX)

• DME Name: Cholesterol 24-hydroxylase (CYP46A1) DME Info
• Gene Name: CYP46A1

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	2.88E-08	6.06E-02	2.80E-01
Alopecia	ED70	Skin from scalp	4.46E-02	2.83E-01	3.87E-01
Alzheimer's disease	8A20	Entorhinal cortex	1.79E-06	-3.32E-01	-6.53E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	9.09E-01	6.15E-02	5.60E-01
Aortic stenosis	BB70	Calcified aortic valve	3.53E-01	5.21E-01	7.14E-01
Apnea	7A40	Hyperplastic tonsil	4.55E-01	-3.86E-03	-1.87E-02
Arthropathy	FA00-FA5Z	Peripheral blood	6.68E-01	-1.10E-02	-8.58E-02
Asthma	CA23	Nasal and bronchial airway	1.11E-01	-1.04E-01	-1.51E-01
Atopic dermatitis	EA80	Skin	9.79E-01	3.05E-02	1.44E-01
Autism	6A02	Whole blood	2.99E-01	-4.43E-02	-1.59E-01
Autoimmune uveitis	9A96	Peripheral monocyte	5.56E-01	3.54E-03	2.30E-02
Autosomal dominant monocytopenia	4B04	Whole blood	6.91E-01	4.86E-03	2.94E-02
Bacterial infection of gingival	1C1H	Gingival tissue	8.34E-02	7.96E-02	3.18E-01
Batten disease	5C56.1	Whole blood	1.63E-01	9.57E-02	5.72E-01
Behcet's disease	4A62	Peripheral blood	8.37E-01	-1.41E-01	-4.35E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	6.33E-01	9.40E-03	3.15E-02
Bladder cancer	2C94	Bladder tissue	2.35E-02	5.94E-01	1.44E+00
Breast cancer	2C60-2C6Z	Breast tissue	1.23E-39	-5.55E-01	-1.04E+00
Cardioembolic stroke	8B11.20	Whole blood	6.38E-02	1.30E-01	3.72E-01
Cervical cancer	2C77	Cervical tissue	5.77E-01	7.84E-02	2.86E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	7.01E-01	1.76E-02	7.46E-02
Chronic hepatitis C	1E51.1	Whole blood	3.02E-01	1.91E-01	8.36E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	2.46E-02	-2.30E-01	-5.92E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	8.48E-01	-5.85E-02	-1.68E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	2.88E-01	-1.45E-01	-9.60E-01
Colon cancer	2B90	Colon tissue	2.33E-01	3.78E-02	1.06E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	9.19E-01	-7.38E-02	-4.31E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	6.01E-01	6.24E-02	2.35E-01
Endometriosis	GA10	Endometrium tissue	4.34E-01	-1.42E-01	-3.52E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	3.81E-01	-3.89E-02	-1.66E-01
Familial hypercholesterolemia	5C80.00	Whole blood	6.51E-03	-1.25E-01	-2.70E-01
Gastric cancer	2B72	Gastric tissue	3.61E-01	-7.16E-01	-1.35E+00
Glioblastopma	2A00.00	Nervous tissue	2.29E-178	-2.96E+00	-2.64E+00
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	3.55E-11	-1.23E+00	-2.36E+01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	5.13E-01	-2.44E-01	-3.36E-01
Head and neck cancer	2D42	Head and neck tissue	4.77E-08	-3.01E-01	-6.54E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	3.74E-01	-2.14E-01	-2.39E-01
Huntington's disease	8A01.10	Whole blood	6.13E-01	2.69E-03	1.29E-02
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	2.09E-01	-2.65E-01	-9.23E-01
Immunodeficiency	4A00-4A20	Peripheral blood	7.86E-01	-3.11E-02	-3.58E-01
Influenza	1E30	Whole blood	7.61E-01	-1.68E-01	-1.08E+00
Interstitial cystitis	GC00.3	Bladder tissue	1.18E-02	4.64E-01	1.68E+00
Intracranial aneurysm	8B01.0	Intracranial artery	2.91E-01	1.63E-01	4.43E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	8.25E-01	-5.86E-02	-2.40E-01
Ischemic stroke	8B11	Peripheral blood	7.58E-02	1.57E-01	6.65E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	2.47E-01	-5.71E-02	-1.78E-01
Lateral sclerosis	8B60.4	Skin	6.25E-01	-9.62E-03	-6.10E-02
Lateral sclerosis	8B60.4	Cervical spinal cord	2.32E-01	1.16E-01	2.14E-01
Liver cancer	2C12.0	Liver tissue	1.45E-03	-2.55E-01	-6.22E-01
Liver failure	DB99.7-DB99.8	Liver tissue	7.70E-02	-2.24E-01	-6.73E-01
Lung cancer	2C25	Lung tissue	2.62E-04	-1.56E-01	-4.02E-01
Lupus erythematosus	4A40	Whole blood	1.10E-02	-9.30E-02	-2.32E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	3.31E-01	2.49E-02	9.07E-02
Major depressive disorder	6A70-6A7Z	Whole blood	9.26E-01	-4.82E-02	-1.48E-01
Melanoma	2C30	Skin	7.38E-03	-3.56E-01	-4.73E-01
Multiple myeloma	2A83.1	Peripheral blood	5.95E-01	-1.44E-02	-9.22E-02
Multiple myeloma	2A83.1	Bone marrow	4.24E-05	-4.31E-01	-2.93E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	2.82E-01	-1.07E-01	-6.61E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	2.41E-02	-8.86E-03	-6.07E-02
Myelofibrosis	2A20.2	Whole blood	1.94E-02	2.64E-01	1.56E+00
Myocardial infarction	BA41-BA50	Peripheral blood	4.64E-02	9.05E-02	2.19E-01
Myopathy	8C70.6	Muscle tissue	1.94E-01	-9.04E-02	-5.19E-01
Neonatal sepsis	KA60	Whole blood	2.58E-04	-1.88E-01	-6.50E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	3.07E-12	-2.59E+00	-7.67E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	3.38E-01	-8.38E-02	-2.79E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	1.93E-01	7.87E-03	3.09E-02
Olive pollen allergy	CA08.00	Peripheral blood	2.38E-02	2.75E-01	1.45E+00
Oral cancer	2B6E	Oral tissue	1.65E-06	-4.73E-01	-1.17E+00
Osteoarthritis	FA00-FA0Z	Synovial tissue	9.79E-01	-3.36E-02	-1.38E-01
Osteoporosis	FB83.1	Bone marrow	1.67E-02	3.02E-01	1.66E+00
Ovarian cancer	2C73	Ovarian tissue	9.86E-04	-7.09E-01	-1.81E+00
Pancreatic cancer	2C10	Pancreas	7.62E-07	-8.75E-01	-2.23E+00
Parkinson's disease	8A00.0	Substantia nigra tissue	6.67E-01	-1.57E-01	-4.94E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	6.66E-03	-1.88E-01	-1.25E+00
Pituitary cancer	2D12	Pituitary tissue	7.32E-03	-4.13E-01	-9.72E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	4.67E-01	-1.93E-01	-3.68E-01
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	8.87E-01	-1.73E-01	-7.94E-01
Polycythemia vera	2A20.4	Whole blood	7.16E-04	1.49E-01	8.32E-01
Pompe disease	5C51.3	Biceps muscle	3.41E-01	-1.47E-01	-8.72E-01
Preterm birth	KA21.4Z	Myometrium	7.62E-01	-1.57E-02	-2.28E-02
Prostate cancer	2C82	Prostate	7.16E-03	3.76E-01	6.82E-01
Psoriasis	EA90	Skin	1.28E-01	1.42E-01	3.43E-01
Rectal cancer	2B92	Rectal colon tissue	3.94E-01	-1.34E-01	-2.98E-01
Renal cancer	2C90-2C91	Kidney	6.86E-02	-5.23E-01	-1.21E+00
Retinoblastoma	2D02.2	Uvea	3.95E-11	-3.16E+00	-1.20E+01
Rheumatoid arthritis	FA20	Synovial tissue	2.93E-03	-5.73E-01	-1.91E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	4.38E-01	-1.93E-02	-1.06E-01
Schizophrenia	6A20	Prefrontal cortex	1.13E-01	-1.62E-01	-6.96E-02
Schizophrenia	6A20	Superior temporal cortex	4.06E-01	1.45E-01	3.65E-01
Scleroderma	4A42.Z	Whole blood	7.24E-04	4.83E-01	1.64E+00
Seizure	8A60-8A6Z	Whole blood	6.36E-01	5.69E-02	3.55E-01
Sensitive skin	EK0Z	Skin	1.46E-01	2.41E-01	8.81E-01
Sepsis with septic shock	1G41	Whole blood	1.29E-09	-3.02E-01	-9.13E-01
Shwachman-Diamond syndrome	3A70.0	Bone marrow	4.15E-01	-3.79E-02	-1.69E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	2.41E-01	1.31E-01	4.63E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	5.06E-01	-3.10E-04	-7.28E-04
Sjogren's syndrome	4A43.2	Salivary gland tissue	5.07E-01	-2.85E-01	-1.68E+00
Skin cancer	2C30-2C3Z	Skin	9.34E-01	-1.07E-01	-2.45E-01
Thrombocythemia	3B63	Whole blood	1.80E-01	1.18E-01	7.13E-01
Thrombocytopenia	3B64	Whole blood	5.90E-01	-1.03E-02	-4.59E-02
Thyroid cancer	2D10	Thyroid	1.92E-07	-2.83E-01	-7.53E-01
Tibial muscular dystrophy	8C75	Muscle tissue	6.84E-01	5.06E-02	1.16E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	2.15E-01	-3.61E-01	-1.13E+00
Type 2 diabetes	5A11	Liver tissue	9.18E-01	-1.03E-02	-4.22E-02
Ureter cancer	2C92	Urothelium	7.10E-01	-1.42E-02	-7.56E-02
Uterine cancer	2C78	Endometrium tissue	3.65E-26	-7.77E-01	-1.26E+00
Vitiligo	ED63.0	Skin	7.90E-01	-4.56E-02	-2.06E-01