Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DELNI4J)

• DME Name: Lecithin-cholesterol acyltransferase (LCAT) DME Info
• Gene Name: LCAT

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	3.75E-02	2.46E-02	1.32E-01
Alopecia	ED70	Skin from scalp	1.22E-02	1.99E-01	5.35E-01
Alzheimer's disease	8A20	Entorhinal cortex	2.13E-06	1.66E-01	7.84E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	7.69E-01	-1.47E-02	-1.58E-01
Aortic stenosis	BB70	Calcified aortic valve	8.26E-01	-3.40E-02	-3.66E-01
Apnea	7A40	Hyperplastic tonsil	3.20E-01	-1.28E-01	-7.72E-01
Arthropathy	FA00-FA5Z	Peripheral blood	3.58E-01	-5.93E-02	-4.36E-01
Asthma	CA23	Nasal and bronchial airway	4.45E-04	-1.75E-01	-5.38E-01
Atopic dermatitis	EA80	Skin	4.65E-05	2.45E-01	2.56E+00
Autism	6A02	Whole blood	5.20E-01	4.29E-02	2.38E-01
Autoimmune uveitis	9A96	Peripheral monocyte	4.93E-01	6.20E-02	3.98E-01
Autosomal dominant monocytopenia	4B04	Whole blood	2.57E-03	-2.54E-01	-1.28E+00
Bacterial infection of gingival	1C1H	Gingival tissue	2.26E-03	7.67E-02	3.38E-01
Batten disease	5C56.1	Whole blood	6.73E-01	6.27E-02	5.36E-01
Behcet's disease	4A62	Peripheral blood	3.05E-01	-9.38E-03	-6.36E-02
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	5.58E-01	-3.17E-03	-1.59E-02
Bladder cancer	2C94	Bladder tissue	7.64E-01	5.50E-02	2.01E-01
Breast cancer	2C60-2C6Z	Breast tissue	2.80E-04	-6.75E-02	-2.13E-01
Cardioembolic stroke	8B11.20	Whole blood	1.80E-02	1.19E-01	6.56E-01
Cervical cancer	2C77	Cervical tissue	6.33E-01	-1.99E-02	-9.01E-02
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	4.53E-01	-6.36E-02	-1.32E-01
Chronic hepatitis C	1E51.1	Whole blood	8.24E-01	5.39E-02	3.65E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	3.02E-02	-1.91E-01	-5.28E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	1.90E-01	-1.45E-02	-7.67E-02
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	7.37E-01	2.50E-02	1.12E-01
Colon cancer	2B90	Colon tissue	1.36E-04	5.76E-02	2.73E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	9.14E-01	1.16E-01	2.36E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	7.15E-01	-5.82E-02	-1.56E-01
Endometriosis	GA10	Endometrium tissue	5.05E-02	-6.88E-02	-2.72E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	2.88E-01	5.55E-02	3.93E-01
Familial hypercholesterolemia	5C80.00	Whole blood	7.12E-01	5.74E-02	4.34E-01
Gastric cancer	2B72	Gastric tissue	3.26E-01	-2.12E-01	-6.09E-01
Glioblastopma	2A00.00	Nervous tissue	3.35E-69	5.43E-01	1.40E+00
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	1.47E-01	3.31E-01	2.28E+00
Glioma	2A00.0Y-2A00.0Z	White matter tissue	1.01E-01	2.38E-02	1.41E-01
Head and neck cancer	2D42	Head and neck tissue	3.53E-21	2.70E-01	1.35E+00
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	1.60E-01	1.43E-01	7.07E-01
Huntington's disease	8A01.10	Whole blood	7.51E-01	8.68E-02	6.74E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	9.85E-01	-3.95E-02	-1.66E-01
Immunodeficiency	4A00-4A20	Peripheral blood	7.35E-01	-6.78E-02	-7.78E-01
Influenza	1E30	Whole blood	3.72E-02	1.47E-01	2.79E+00
Interstitial cystitis	GC00.3	Bladder tissue	2.95E-01	8.38E-02	3.65E-01
Intracranial aneurysm	8B01.0	Intracranial artery	6.29E-01	-3.52E-03	-9.68E-03
Irritable bowel syndrome	DD91.0	Rectal colon tissue	8.88E-01	-3.96E-02	-1.50E-01
Ischemic stroke	8B11	Peripheral blood	8.63E-01	4.57E-02	3.36E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	2.04E-04	-1.53E-01	-6.19E-01
Lateral sclerosis	8B60.4	Skin	7.35E-01	-5.54E-02	-9.37E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	5.22E-01	3.01E-02	1.88E-01
Liver cancer	2C12.0	Liver tissue	3.21E-30	-1.60E+00	-3.76E+00
Liver failure	DB99.7-DB99.8	Liver tissue	1.29E-06	-1.25E+00	-4.00E+00
Lung cancer	2C25	Lung tissue	1.67E-50	-3.83E-01	-1.62E+00
Lupus erythematosus	4A40	Whole blood	6.14E-01	2.51E-02	1.05E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	5.23E-01	4.04E-02	2.02E-01
Major depressive disorder	6A70-6A7Z	Whole blood	4.84E-01	1.61E-02	6.80E-02
Melanoma	2C30	Skin	2.56E-03	-5.61E-01	-9.61E-01
Multiple myeloma	2A83.1	Peripheral blood	4.53E-01	-3.28E-02	-3.89E-01
Multiple myeloma	2A83.1	Bone marrow	4.96E-01	-5.67E-02	-3.47E-01
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	7.52E-01	1.15E-01	9.47E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	4.20E-01	-5.07E-02	-4.14E-01
Myelofibrosis	2A20.2	Whole blood	1.37E-01	-1.08E-01	-1.16E+00
Myocardial infarction	BA41-BA50	Peripheral blood	8.18E-03	5.99E-02	1.84E-01
Myopathy	8C70.6	Muscle tissue	5.68E-01	-2.15E-02	-1.78E-01
Neonatal sepsis	KA60	Whole blood	7.12E-01	-4.72E-02	-2.30E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	4.29E-05	-3.50E-01	-2.05E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	4.80E-01	3.35E-01	7.53E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	3.33E-02	1.62E-01	3.70E+00
Olive pollen allergy	CA08.00	Peripheral blood	4.67E-01	-7.97E-03	-2.20E-02
Oral cancer	2B6E	Oral tissue	1.69E-01	5.45E-02	2.75E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	4.23E-01	1.53E-02	3.62E-02
Osteoporosis	FB83.1	Bone marrow	3.54E-04	4.45E-01	4.04E+00
Ovarian cancer	2C73	Ovarian tissue	8.60E-04	-4.28E-01	-1.79E+00
Pancreatic cancer	2C10	Pancreas	9.98E-01	-5.76E-02	-1.29E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	5.00E-01	-7.85E-03	-3.85E-02
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	2.93E-01	-1.59E-02	-1.35E-01
Pituitary cancer	2D12	Pituitary tissue	4.76E-05	-4.31E-01	-2.68E+00
Pituitary gonadotrope tumour	2D12	Pituitary tissue	3.01E-06	-5.85E-01	-3.27E+00
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	4.29E-01	-7.60E-03	-5.13E-02
Polycythemia vera	2A20.4	Whole blood	4.61E-01	-1.89E-03	-1.97E-02
Pompe disease	5C51.3	Biceps muscle	4.74E-03	2.67E-01	1.49E+00
Preterm birth	KA21.4Z	Myometrium	5.39E-01	1.04E-01	3.90E-01
Prostate cancer	2C82	Prostate	4.42E-01	2.48E-02	6.02E-02
Psoriasis	EA90	Skin	2.07E-08	1.94E-01	5.63E-01
Rectal cancer	2B92	Rectal colon tissue	6.79E-01	1.32E-01	5.49E-01
Renal cancer	2C90-2C91	Kidney	2.06E-01	1.98E-01	7.09E-01
Retinoblastoma	2D02.2	Uvea	8.25E-06	5.46E-01	5.24E+00
Rheumatoid arthritis	FA20	Synovial tissue	3.88E-03	2.38E-01	1.52E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	9.32E-01	1.62E-02	1.12E-01
Schizophrenia	6A20	Prefrontal cortex	2.87E-01	8.54E-02	3.98E-01
Schizophrenia	6A20	Superior temporal cortex	9.65E-01	4.52E-02	2.86E-01
Scleroderma	4A42.Z	Whole blood	4.52E-05	2.90E-01	2.74E+00
Seizure	8A60-8A6Z	Whole blood	2.48E-01	8.03E-02	4.23E-01
Sensitive skin	EK0Z	Skin	1.06E-01	8.12E-02	4.97E-01
Sepsis with septic shock	1G41	Whole blood	1.71E-02	-7.95E-02	-4.22E-01
Shwachman-Diamond syndrome	3A70.0	Bone marrow	7.55E-01	2.91E-02	2.43E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	6.72E-01	4.22E-02	2.18E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	2.73E-01	1.55E-01	9.73E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	2.49E-01	-2.26E-01	-1.03E+00
Skin cancer	2C30-2C3Z	Skin	8.78E-14	-2.56E-01	-6.80E-01
Thrombocythemia	3B63	Whole blood	1.44E-01	2.49E-02	2.69E-01
Thrombocytopenia	3B64	Whole blood	4.11E-01	4.32E-01	6.47E-01
Thyroid cancer	2D10	Thyroid	6.62E-05	-9.94E-02	-4.78E-01
Tibial muscular dystrophy	8C75	Muscle tissue	2.53E-01	-4.91E-02	-1.72E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	3.08E-02	7.79E-01	4.31E+00
Type 2 diabetes	5A11	Liver tissue	2.70E-01	-1.26E-01	-3.52E-01
Ureter cancer	2C92	Urothelium	8.31E-01	-2.11E-02	-8.17E-02
Uterine cancer	2C78	Endometrium tissue	3.02E-11	-3.95E-01	-8.90E-01
Vitiligo	ED63.0	Skin	2.38E-01	8.41E-02	8.45E-01