Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DEMJ7R2)

• DME Name: Amidophosphoribosyltransferase (GPAT) DME Info
• Gene Name: PPAT

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	1.77E-05	1.49E-01	2.59E-01
Alopecia	ED70	Skin from scalp	7.83E-01	-3.98E-02	-9.25E-02
Alzheimer's disease	8A20	Entorhinal cortex	2.58E-01	7.50E-02	3.10E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	5.02E-01	-2.94E-02	-1.39E-01
Aortic stenosis	BB70	Calcified aortic valve	2.88E-01	1.01E-01	4.59E-01
Apnea	7A40	Hyperplastic tonsil	2.87E-01	-1.68E-01	-2.34E-01
Arthropathy	FA00-FA5Z	Peripheral blood	1.08E-01	-1.93E-01	-5.63E-01
Asthma	CA23	Nasal and bronchial airway	3.35E-01	1.00E-01	1.73E-01
Atopic dermatitis	EA80	Skin	6.43E-01	1.91E-01	6.56E-01
Autism	6A02	Whole blood	2.41E-01	8.02E-02	2.30E-01
Autoimmune uveitis	9A96	Peripheral monocyte	3.73E-01	4.84E-02	3.79E-01
Autosomal dominant monocytopenia	4B04	Whole blood	4.61E-01	2.23E-01	1.66E+00
Bacterial infection of gingival	1C1H	Gingival tissue	9.11E-02	-7.81E-02	-2.31E-01
Batten disease	5C56.1	Whole blood	8.78E-01	-1.73E-01	-2.58E-01
Behcet's disease	4A62	Peripheral blood	3.02E-01	-2.56E-01	-7.86E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	5.16E-02	7.16E-02	3.19E-01
Bladder cancer	2C94	Bladder tissue	8.47E-06	4.72E-01	2.60E+00
Breast cancer	2C60-2C6Z	Breast tissue	9.35E-43	8.76E-01	1.21E+00
Cardioembolic stroke	8B11.20	Whole blood	9.32E-01	6.38E-02	1.75E-01
Cervical cancer	2C77	Cervical tissue	9.56E-03	2.59E-01	5.25E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	5.27E-01	4.64E-02	7.06E-02
Chronic hepatitis C	1E51.1	Whole blood	5.78E-01	8.68E-02	2.43E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	5.10E-01	-2.20E-02	-1.09E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	5.10E-03	-1.78E-01	-5.61E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	1.68E-01	1.49E-01	6.55E-01
Colon cancer	2B90	Colon tissue	9.75E-89	1.30E+00	2.97E+00
Coronary artery disease	BA80-BA8Z	Peripheral blood	8.43E-02	1.42E-01	7.89E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	6.78E-01	3.38E-02	6.86E-02
Endometriosis	GA10	Endometrium tissue	4.40E-01	-8.79E-02	-1.51E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	5.33E-01	7.65E-02	2.02E-01
Familial hypercholesterolemia	5C80.00	Whole blood	3.53E-03	-2.71E-01	-1.17E+00
Gastric cancer	2B72	Gastric tissue	6.82E-02	1.17E+00	1.86E+00
Glioblastopma	2A00.00	Nervous tissue	1.51E-48	4.55E-01	1.02E+00
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	2.52E-01	1.90E-01	1.16E+00
Glioma	2A00.0Y-2A00.0Z	White matter tissue	4.67E-04	5.84E-01	7.19E-01
Head and neck cancer	2D42	Head and neck tissue	8.06E-31	5.81E-01	2.16E+00
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	6.45E-01	-1.01E-01	-4.07E-01
Huntington's disease	8A01.10	Whole blood	8.73E-01	1.09E-02	3.71E-02
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	8.67E-01	2.36E-01	2.45E-01
Immunodeficiency	4A00-4A20	Peripheral blood	4.03E-01	2.99E-01	1.57E+00
Influenza	1E30	Whole blood	1.61E-01	-2.27E-01	-4.74E-01
Interstitial cystitis	GC00.3	Bladder tissue	4.75E-01	7.29E-02	3.23E-01
Intracranial aneurysm	8B01.0	Intracranial artery	3.47E-01	3.77E-01	6.32E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	1.59E-01	9.74E-02	2.93E-01
Ischemic stroke	8B11	Peripheral blood	6.20E-02	-2.76E-01	-8.42E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	5.67E-01	-7.33E-02	-1.52E-01
Lateral sclerosis	8B60.4	Skin	5.23E-01	1.16E-01	3.48E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	8.41E-01	-2.24E-01	-4.66E-01
Liver cancer	2C12.0	Liver tissue	3.55E-06	4.61E-01	8.19E-01
Liver failure	DB99.7-DB99.8	Liver tissue	5.06E-03	-7.45E-01	-2.06E+00
Lung cancer	2C25	Lung tissue	2.78E-138	1.47E+00	3.49E+00
Lupus erythematosus	4A40	Whole blood	3.01E-01	3.25E-01	3.27E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	5.15E-01	2.10E-02	9.46E-02
Major depressive disorder	6A70-6A7Z	Whole blood	2.71E-01	-2.34E-01	-3.84E-01
Melanoma	2C30	Skin	4.60E-02	3.21E-01	3.13E-01
Multiple myeloma	2A83.1	Peripheral blood	5.13E-01	-2.89E-01	-3.28E-01
Multiple myeloma	2A83.1	Bone marrow	9.57E-05	6.19E-01	2.48E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	2.76E-02	-6.60E-01	-1.40E+00
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	2.65E-03	7.11E-01	9.84E-01
Myelofibrosis	2A20.2	Whole blood	1.67E-01	5.10E-02	2.64E-01
Myocardial infarction	BA41-BA50	Peripheral blood	3.09E-02	-7.01E-01	-6.29E-01
Myopathy	8C70.6	Muscle tissue	8.11E-01	9.13E-02	1.51E-01
Neonatal sepsis	KA60	Whole blood	1.23E-12	-5.72E-01	-1.27E+00
Neuroectodermal tumour	2A00.11	Brain stem tissue	2.15E-08	1.78E+00	3.89E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	8.19E-01	2.18E-01	5.94E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	1.60E-01	-5.59E-01	-6.01E-01
Olive pollen allergy	CA08.00	Peripheral blood	4.02E-01	-5.72E-01	-6.47E-01
Oral cancer	2B6E	Oral tissue	1.84E-04	4.91E-01	7.22E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	3.36E-01	2.34E-01	6.11E-01
Osteoporosis	FB83.1	Bone marrow	4.98E-01	1.31E-01	2.46E-01
Ovarian cancer	2C73	Ovarian tissue	4.24E-03	8.10E-01	1.32E+00
Pancreatic cancer	2C10	Pancreas	5.09E-02	-1.10E-01	-2.81E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	7.78E-01	-3.44E-02	-1.21E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	4.86E-01	-1.03E-01	-3.01E-01
Pituitary cancer	2D12	Pituitary tissue	4.61E-01	1.40E-01	2.29E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	9.91E-01	1.37E-01	2.99E-01
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	3.54E-01	-6.03E-02	-3.33E-01
Polycythemia vera	2A20.4	Whole blood	4.67E-01	-4.53E-02	-3.56E-01
Pompe disease	5C51.3	Biceps muscle	1.31E-04	-4.76E-01	-1.98E+00
Preterm birth	KA21.4Z	Myometrium	7.31E-01	1.21E-01	2.50E-01
Prostate cancer	2C82	Prostate	3.99E-09	1.99E+00	2.38E+00
Psoriasis	EA90	Skin	3.00E-15	3.76E-01	6.90E-01
Rectal cancer	2B92	Rectal colon tissue	2.35E-04	1.00E+00	3.01E+00
Renal cancer	2C90-2C91	Kidney	4.14E-03	6.23E-01	1.24E+00
Retinoblastoma	2D02.2	Uvea	7.52E-05	9.50E-01	3.53E+00
Rheumatoid arthritis	FA20	Synovial tissue	9.25E-02	-3.60E-01	-9.68E-01
Rhinovirus infection	CA42.1	Nasal epithelium tissue	3.09E-01	5.48E-02	2.94E-01
Schizophrenia	6A20	Prefrontal cortex	6.35E-01	-8.06E-02	-2.52E-01
Schizophrenia	6A20	Superior temporal cortex	5.98E-01	2.18E-02	1.74E-01
Scleroderma	4A42.Z	Whole blood	1.49E-03	-4.43E-01	-1.94E+00
Seizure	8A60-8A6Z	Whole blood	8.64E-01	3.95E-02	8.82E-02
Sensitive skin	EK0Z	Skin	7.56E-01	5.62E-02	3.46E-01
Sepsis with septic shock	1G41	Whole blood	8.62E-25	-5.69E-01	-1.23E+00
Shwachman-Diamond syndrome	3A70.0	Bone marrow	7.72E-01	1.17E-03	2.64E-03
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	1.26E-02	-1.72E-01	-5.27E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	7.92E-01	2.17E-01	2.18E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	3.70E-01	3.52E-01	1.19E+00
Skin cancer	2C30-2C3Z	Skin	2.20E-68	1.49E+00	2.13E+00
Thrombocythemia	3B63	Whole blood	2.26E-01	-4.02E-02	-2.25E-01
Thrombocytopenia	3B64	Whole blood	6.14E-01	2.81E-02	2.16E-02
Thyroid cancer	2D10	Thyroid	4.64E-01	-1.80E-01	-6.34E-01
Tibial muscular dystrophy	8C75	Muscle tissue	3.77E-01	1.69E-01	5.35E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	1.12E-01	-2.25E-01	-1.60E+00
Type 2 diabetes	5A11	Liver tissue	2.10E-01	2.31E-01	6.39E-01
Ureter cancer	2C92	Urothelium	5.82E-01	4.11E-03	1.80E-02
Uterine cancer	2C78	Endometrium tissue	1.12E-24	7.73E-01	1.29E+00
Vitiligo	ED63.0	Skin	9.33E-01	-4.12E-02	-1.72E-01