Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DEP6GT1)

• DME Name: Small intestine reductase (AKR1B10) DME Info
• Gene Name: AKR1B10

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	2.07E-05	3.93E-02	2.67E-01
Alopecia	ED70	Skin from scalp	3.12E-01	-2.58E-01	-2.61E-01
Alzheimer's disease	8A20	Entorhinal cortex	2.61E-01	-4.15E-02	-2.61E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	2.69E-01	-1.65E-01	-1.05E+00
Aortic stenosis	BB70	Calcified aortic valve	9.09E-01	-1.83E-01	-3.80E-01
Apnea	7A40	Hyperplastic tonsil	7.42E-02	-3.31E+00	-3.34E+00
Arthropathy	FA00-FA5Z	Peripheral blood	5.70E-01	8.24E-02	4.86E-01
Asthma	CA23	Nasal and bronchial airway	3.80E-10	2.78E+00	1.36E+00
Atopic dermatitis	EA80	Skin	1.42E-08	2.49E+00	7.15E+00
Autism	6A02	Whole blood	7.37E-03	-1.93E-01	-8.54E-01
Autoimmune uveitis	9A96	Peripheral monocyte	6.49E-01	-2.00E-01	-8.45E-01
Autosomal dominant monocytopenia	4B04	Whole blood	6.17E-01	-4.15E-02	-2.98E-01
Bacterial infection of gingival	1C1H	Gingival tissue	2.92E-15	-5.00E-01	-1.24E+00
Batten disease	5C56.1	Whole blood	4.03E-01	-4.80E-02	-3.28E-01
Behcet's disease	4A62	Peripheral blood	1.62E-01	9.59E-02	6.92E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	6.74E-01	1.97E-02	1.37E-01
Bladder cancer	2C94	Bladder tissue	6.74E-01	-7.75E-01	-5.47E-01
Breast cancer	2C60-2C6Z	Breast tissue	3.42E-02	-5.90E-02	-6.89E-02
Cardioembolic stroke	8B11.20	Whole blood	2.14E-03	-1.40E-01	-7.35E-01
Cervical cancer	2C77	Cervical tissue	3.40E-04	-1.00E+00	-1.13E+00
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	8.77E-01	3.67E-04	2.25E-03
Chronic hepatitis C	1E51.1	Whole blood	1.05E-02	1.02E-01	7.65E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	3.11E-03	9.42E-02	6.13E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	1.99E-07	2.52E+00	9.84E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	1.01E-01	6.81E-01	1.97E+00
Colon cancer	2B90	Colon tissue	3.19E-198	-4.07E+00	-5.86E+00
Coronary artery disease	BA80-BA8Z	Peripheral blood	4.35E-01	-7.10E-02	-5.04E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	4.09E-01	-9.61E-02	-5.07E-01
Endometriosis	GA10	Endometrium tissue	9.43E-03	1.65E-01	3.48E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	1.75E-01	8.72E-02	6.03E-01
Familial hypercholesterolemia	5C80.00	Whole blood	3.34E-03	-1.14E-01	-6.72E-01
Gastric cancer	2B72	Gastric tissue	1.76E-01	-2.98E+00	-1.39E+00
Glioblastopma	2A00.00	Nervous tissue	1.55E-06	9.51E-02	2.97E-01
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	6.78E-01	2.63E-03	1.63E-02
Glioma	2A00.0Y-2A00.0Z	White matter tissue	7.00E-01	-2.65E-01	-9.17E-01
Head and neck cancer	2D42	Head and neck tissue	2.63E-10	1.82E+00	8.15E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	7.60E-02	-1.02E-01	-3.15E-01
Huntington's disease	8A01.10	Whole blood	5.05E-01	-2.38E-02	-1.73E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	2.79E-02	1.61E-01	7.34E-01
Immunodeficiency	4A00-4A20	Peripheral blood	5.86E-01	2.60E-02	3.47E-01
Influenza	1E30	Whole blood	4.44E-01	4.99E-02	7.86E-01
Interstitial cystitis	GC00.3	Bladder tissue	8.59E-02	-1.30E+00	-9.43E-01
Intracranial aneurysm	8B01.0	Intracranial artery	3.74E-01	-1.31E-01	-2.29E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	5.36E-01	-1.42E-01	-2.23E-01
Ischemic stroke	8B11	Peripheral blood	5.20E-01	-3.06E-02	-2.12E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	7.62E-03	6.46E-02	2.41E-01
Lateral sclerosis	8B60.4	Skin	7.91E-01	-3.01E-02	-1.33E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	1.93E-02	2.58E-01	1.38E+00
Liver cancer	2C12.0	Liver tissue	2.44E-31	5.33E+00	4.44E+00
Liver failure	DB99.7-DB99.8	Liver tissue	1.70E-04	5.81E+00	5.18E+00
Lung cancer	2C25	Lung tissue	4.46E-96	1.16E+00	1.81E+00
Lupus erythematosus	4A40	Whole blood	3.95E-04	8.38E-02	3.18E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	9.36E-01	2.19E-02	1.52E-01
Major depressive disorder	6A70-6A7Z	Whole blood	3.30E-01	6.17E-02	2.24E-01
Melanoma	2C30	Skin	6.71E-01	6.54E-01	4.16E-01
Multiple myeloma	2A83.1	Peripheral blood	3.25E-01	2.43E-02	1.81E-01
Multiple myeloma	2A83.1	Bone marrow	1.37E-03	-6.04E-01	-2.11E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	9.40E-01	7.80E-03	3.57E-02
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	7.62E-01	-1.44E-02	-6.53E-02
Myelofibrosis	2A20.2	Whole blood	2.43E-04	-1.11E-01	-8.27E-01
Myocardial infarction	BA41-BA50	Peripheral blood	4.34E-01	-3.91E-03	-6.65E-03
Myopathy	8C70.6	Muscle tissue	4.74E-01	-2.17E-01	-2.30E-01
Neonatal sepsis	KA60	Whole blood	7.28E-01	-1.35E-02	-6.86E-02
Neuroectodermal tumour	2A00.11	Brain stem tissue	1.94E-03	-5.54E-01	-1.64E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	9.62E-01	-9.63E-02	-8.42E-02
Obesity related type 2 diabetes	5A11	Omental adipose tissue	7.60E-01	6.93E-02	2.71E-01
Olive pollen allergy	CA08.00	Peripheral blood	4.41E-01	-3.81E-02	-2.23E-01
Oral cancer	2B6E	Oral tissue	8.29E-01	-1.60E-01	-7.21E-02
Osteoarthritis	FA00-FA0Z	Synovial tissue	5.47E-01	5.48E-01	7.95E-01
Osteoporosis	FB83.1	Bone marrow	9.64E-02	-4.54E-01	-1.32E+00
Ovarian cancer	2C73	Ovarian tissue	1.76E-03	2.13E-01	4.10E-01
Pancreatic cancer	2C10	Pancreas	2.04E-03	2.09E+00	1.14E+00
Parkinson's disease	8A00.0	Substantia nigra tissue	3.02E-01	-7.97E-02	-5.85E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	2.21E-01	-1.16E-01	-8.70E-01
Pituitary cancer	2D12	Pituitary tissue	2.64E-01	1.23E+00	1.41E+00
Pituitary gonadotrope tumour	2D12	Pituitary tissue	8.36E-03	1.55E+00	1.94E+00
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	2.40E-01	1.38E-01	3.96E-01
Polycythemia vera	2A20.4	Whole blood	8.08E-03	-7.33E-02	-5.58E-01
Pompe disease	5C51.3	Biceps muscle	5.36E-03	-1.91E+00	-2.51E+00
Preterm birth	KA21.4Z	Myometrium	2.76E-01	1.91E-01	7.37E-01
Prostate cancer	2C82	Prostate	8.76E-02	-2.47E-01	-1.91E-01
Psoriasis	EA90	Skin	8.35E-67	5.29E+00	5.44E+00
Rectal cancer	2B92	Rectal colon tissue	2.45E-08	-2.70E+00	-5.84E+00
Renal cancer	2C90-2C91	Kidney	8.30E-01	-1.10E-01	-5.50E-02
Retinoblastoma	2D02.2	Uvea	5.73E-02	-1.72E-01	-8.98E-01
Rheumatoid arthritis	FA20	Synovial tissue	9.59E-04	-1.00E+00	-2.00E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	8.16E-01	5.76E-02	6.05E-02
Schizophrenia	6A20	Prefrontal cortex	2.86E-01	1.08E-02	4.44E-02
Schizophrenia	6A20	Superior temporal cortex	1.24E-01	-5.50E-02	-3.29E-01
Scleroderma	4A42.Z	Whole blood	1.41E-02	7.57E-02	6.10E-01
Seizure	8A60-8A6Z	Whole blood	4.84E-02	7.09E-02	4.09E-01
Sensitive skin	EK0Z	Skin	1.91E-01	1.47E+00	2.11E+00
Sepsis with septic shock	1G41	Whole blood	1.64E-07	1.09E-01	4.95E-01
Shwachman-Diamond syndrome	3A70.0	Bone marrow	2.62E-01	1.17E-01	4.31E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	1.52E-01	1.66E-01	4.36E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	9.29E-01	2.85E-01	2.93E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	2.13E-01	8.26E-02	3.61E-01
Skin cancer	2C30-2C3Z	Skin	2.88E-03	3.23E-01	2.79E-01
Thrombocythemia	3B63	Whole blood	6.24E-01	-5.51E-02	-3.74E-01
Thrombocytopenia	3B64	Whole blood	5.65E-02	2.72E-01	1.52E+00
Thyroid cancer	2D10	Thyroid	2.81E-05	1.10E-01	2.19E-01
Tibial muscular dystrophy	8C75	Muscle tissue	8.43E-08	-1.47E+00	-2.57E+00
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	5.88E-01	1.27E-01	5.95E-01
Type 2 diabetes	5A11	Liver tissue	8.24E-01	-2.13E-01	-2.41E-01
Ureter cancer	2C92	Urothelium	8.76E-01	-8.76E-02	-3.60E-01
Uterine cancer	2C78	Endometrium tissue	3.39E-07	1.63E+00	6.82E-01
Vitiligo	ED63.0	Skin	2.13E-01	-3.81E-01	-5.54E-01