Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DEQJ8N3)

• DME Name: ASM-like phosphodiesterase 3a (SMPDL3A) DME Info
• Gene Name: SMPDL3A

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	2.94E-21	-8.74E-01	-2.51E+00
Alopecia	ED70	Skin from scalp	9.91E-01	-2.69E-02	-1.25E-01
Alzheimer's disease	8A20	Entorhinal cortex	2.60E-01	-8.36E-03	-7.38E-02
Ankylosing spondylitis	FA92.0	Pheripheral blood	4.33E-02	-2.48E-01	-1.11E+00
Aortic stenosis	BB70	Calcified aortic valve	3.04E-01	1.97E-01	8.90E-01
Apnea	7A40	Hyperplastic tonsil	8.93E-01	-2.58E-01	-8.28E-01
Arthropathy	FA00-FA5Z	Peripheral blood	4.82E-01	1.46E-01	6.91E-01
Asthma	CA23	Nasal and bronchial airway	1.06E-02	9.45E-02	1.74E-01
Atopic dermatitis	EA80	Skin	7.55E-05	-3.09E-01	-1.79E+00
Autism	6A02	Whole blood	6.41E-02	1.38E-01	4.86E-01
Autoimmune uveitis	9A96	Peripheral monocyte	2.44E-03	-4.62E-01	-1.26E+00
Autosomal dominant monocytopenia	4B04	Whole blood	4.54E-01	5.10E-01	1.79E+00
Bacterial infection of gingival	1C1H	Gingival tissue	1.88E-17	-2.92E-01	-1.49E+00
Batten disease	5C56.1	Whole blood	6.59E-01	-1.53E-01	-6.55E-01
Behcet's disease	4A62	Peripheral blood	6.90E-01	-2.06E-02	-7.84E-02
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	9.65E-01	1.74E-02	1.87E-01
Bladder cancer	2C94	Bladder tissue	4.78E-06	-5.74E-01	-2.88E+00
Breast cancer	2C60-2C6Z	Breast tissue	3.10E-06	-7.24E-02	-2.12E-01
Cardioembolic stroke	8B11.20	Whole blood	2.50E-08	3.42E-01	1.97E+00
Cervical cancer	2C77	Cervical tissue	8.99E-01	-5.12E-02	-2.79E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	1.34E-01	4.89E-02	1.16E-01
Chronic hepatitis C	1E51.1	Whole blood	5.73E-01	-3.08E-01	-3.43E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	3.94E-01	-5.91E-02	-2.39E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	8.02E-01	9.77E-03	4.09E-02
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	6.18E-02	4.44E-01	2.62E+00
Colon cancer	2B90	Colon tissue	5.16E-135	-1.42E+00	-4.57E+00
Coronary artery disease	BA80-BA8Z	Peripheral blood	9.00E-01	-1.02E-01	-5.26E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	1.61E-01	-3.05E-01	-1.12E+00
Endometriosis	GA10	Endometrium tissue	2.13E-02	3.20E-01	5.05E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	2.29E-01	-3.07E-01	-1.35E+00
Familial hypercholesterolemia	5C80.00	Whole blood	1.50E-06	7.90E-01	1.64E+00
Gastric cancer	2B72	Gastric tissue	9.36E-01	-2.20E-01	-3.22E-01
Glioblastopma	2A00.00	Nervous tissue	6.03E-24	2.03E-01	7.56E-01
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	3.68E-01	-1.54E-01	-8.99E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	2.66E-02	2.83E-01	5.32E-01
Head and neck cancer	2D42	Head and neck tissue	4.74E-04	-1.70E-01	-5.58E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	7.39E-02	-1.02E-01	-6.56E-01
Huntington's disease	8A01.10	Whole blood	8.11E-01	-3.52E-02	-1.07E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	7.64E-02	-4.93E-01	-1.68E+00
Immunodeficiency	4A00-4A20	Peripheral blood	3.75E-03	1.35E-01	1.81E+00
Influenza	1E30	Whole blood	7.42E-03	-5.70E-01	-3.17E+00
Interstitial cystitis	GC00.3	Bladder tissue	2.79E-04	7.35E-01	4.63E+00
Intracranial aneurysm	8B01.0	Intracranial artery	2.11E-03	6.43E-01	2.23E+00
Irritable bowel syndrome	DD91.0	Rectal colon tissue	3.68E-01	-2.12E-03	-1.12E-02
Ischemic stroke	8B11	Peripheral blood	2.77E-01	1.27E-02	3.82E-02
Juvenile idiopathic arthritis	FA24	Peripheral blood	1.93E-07	1.94E-01	5.11E-01
Lateral sclerosis	8B60.4	Skin	5.39E-01	1.04E-01	4.87E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	8.34E-01	-2.07E-02	-1.04E-01
Liver cancer	2C12.0	Liver tissue	2.39E-07	-3.51E-01	-1.10E+00
Liver failure	DB99.7-DB99.8	Liver tissue	1.20E-03	-6.52E-01	-1.90E+00
Lung cancer	2C25	Lung tissue	2.91E-01	-1.11E-02	-3.79E-02
Lupus erythematosus	4A40	Whole blood	4.54E-04	1.89E-01	3.70E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	1.75E-01	1.89E-02	1.77E-01
Major depressive disorder	6A70-6A7Z	Whole blood	1.11E-02	1.53E-01	5.39E-01
Melanoma	2C30	Skin	1.90E-04	-4.72E-01	-1.20E+00
Multiple myeloma	2A83.1	Peripheral blood	6.94E-01	-1.68E-02	-7.76E-02
Multiple myeloma	2A83.1	Bone marrow	1.10E-01	-6.19E-01	-7.43E-01
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	2.36E-01	3.15E-02	1.90E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	3.64E-04	4.85E-01	8.27E-01
Myelofibrosis	2A20.2	Whole blood	1.18E-01	-1.68E-01	-7.69E-01
Myocardial infarction	BA41-BA50	Peripheral blood	5.62E-04	8.28E-01	1.03E+00
Myopathy	8C70.6	Muscle tissue	5.62E-01	3.44E-02	1.14E-01
Neonatal sepsis	KA60	Whole blood	1.16E-40	1.25E+00	3.32E+00
Neuroectodermal tumour	2A00.11	Brain stem tissue	2.49E-05	7.28E-01	2.64E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	6.82E-01	-1.17E-01	-5.04E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	5.54E-01	-7.94E-02	-1.35E+00
Olive pollen allergy	CA08.00	Peripheral blood	8.95E-01	1.81E-01	2.80E-01
Oral cancer	2B6E	Oral tissue	5.17E-02	-2.39E-01	-5.03E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	6.16E-01	-3.54E-02	-8.56E-02
Osteoporosis	FB83.1	Bone marrow	2.80E-01	-1.35E-01	-5.72E-01
Ovarian cancer	2C73	Ovarian tissue	4.27E-01	-2.23E-01	-8.39E-01
Pancreatic cancer	2C10	Pancreas	1.65E-01	1.34E-01	3.49E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	7.96E-01	-1.49E-01	-5.00E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	8.19E-05	5.31E-01	1.07E+00
Pituitary cancer	2D12	Pituitary tissue	3.34E-03	-4.81E-01	-2.06E+00
Pituitary gonadotrope tumour	2D12	Pituitary tissue	4.08E-04	-6.03E-01	-3.05E+00
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	6.62E-01	5.45E-02	2.80E-01
Polycythemia vera	2A20.4	Whole blood	4.42E-05	3.30E-01	1.46E+00
Pompe disease	5C51.3	Biceps muscle	4.36E-05	-4.98E-01	-2.42E+00
Preterm birth	KA21.4Z	Myometrium	9.10E-01	2.88E-02	6.85E-02
Prostate cancer	2C82	Prostate	4.28E-01	9.85E-03	2.16E-02
Psoriasis	EA90	Skin	1.92E-03	-3.21E-02	-1.41E-01
Rectal cancer	2B92	Rectal colon tissue	1.13E-07	-1.21E+00	-6.81E+00
Renal cancer	2C90-2C91	Kidney	4.11E-04	7.51E-01	1.52E+00
Retinoblastoma	2D02.2	Uvea	1.66E-02	2.91E-01	2.32E+00
Rheumatoid arthritis	FA20	Synovial tissue	1.74E-02	3.60E-01	1.18E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	8.57E-01	-1.60E-02	-7.99E-02
Schizophrenia	6A20	Prefrontal cortex	2.14E-01	-1.45E-02	-4.87E-02
Schizophrenia	6A20	Superior temporal cortex	9.53E-01	-2.09E-02	-2.07E-01
Scleroderma	4A42.Z	Whole blood	1.66E-01	1.35E-01	5.92E-01
Seizure	8A60-8A6Z	Whole blood	2.85E-01	-2.64E-01	-6.69E-01
Sensitive skin	EK0Z	Skin	3.60E-01	-5.74E-02	-3.07E-01
Sepsis with septic shock	1G41	Whole blood	7.13E-107	1.27E+00	3.56E+00
Shwachman-Diamond syndrome	3A70.0	Bone marrow	5.86E-01	-1.75E-01	-5.87E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	4.09E-02	-1.44E-01	-9.71E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	7.46E-01	-8.67E-02	-4.05E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	7.45E-02	-3.31E-01	-1.51E+00
Skin cancer	2C30-2C3Z	Skin	2.48E-94	-8.74E-01	-2.96E+00
Thrombocythemia	3B63	Whole blood	7.02E-01	-1.88E-03	-8.64E-03
Thrombocytopenia	3B64	Whole blood	5.38E-01	-1.72E-03	-7.93E-03
Thyroid cancer	2D10	Thyroid	1.50E-11	2.00E-01	1.14E+00
Tibial muscular dystrophy	8C75	Muscle tissue	1.18E-05	-4.59E-01	-2.11E+00
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	3.69E-01	-1.13E-01	-1.27E+00
Type 2 diabetes	5A11	Liver tissue	5.42E-01	8.97E-02	2.32E-01
Ureter cancer	2C92	Urothelium	8.56E-01	2.09E-02	1.37E-01
Uterine cancer	2C78	Endometrium tissue	3.07E-01	-1.09E-01	-2.55E-01
Vitiligo	ED63.0	Skin	2.35E-01	2.97E-02	2.47E-01