Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DESDN74)

• DME Name: Serum paraoxonase/arylesterase 1 (PON1) DME Info
• Gene Name: PON1

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	2.49E-03	2.10E-02	1.35E-01
Alopecia	ED70	Skin from scalp	4.61E-02	1.69E-01	4.59E-01
Alzheimer's disease	8A20	Entorhinal cortex	8.24E-01	3.15E-03	2.07E-02
Ankylosing spondylitis	FA92.0	Pheripheral blood	6.80E-01	2.74E-02	2.65E-01
Aortic stenosis	BB70	Calcified aortic valve	9.76E-01	1.42E-01	2.74E-01
Apnea	7A40	Hyperplastic tonsil	7.17E-02	1.09E-01	5.25E-01
Arthropathy	FA00-FA5Z	Peripheral blood	1.36E-01	2.59E-02	2.48E-01
Asthma	CA23	Nasal and bronchial airway	2.37E-03	-7.71E-02	-2.18E-01
Atopic dermatitis	EA80	Skin	9.82E-04	-6.54E-02	-6.07E-01
Autism	6A02	Whole blood	1.35E-01	-7.75E-02	-3.23E-01
Autoimmune uveitis	9A96	Peripheral monocyte	6.27E-01	-7.15E-02	-4.76E-01
Autosomal dominant monocytopenia	4B04	Whole blood	8.12E-01	8.89E-03	9.70E-02
Bacterial infection of gingival	1C1H	Gingival tissue	4.19E-01	-2.08E-02	-9.48E-02
Batten disease	5C56.1	Whole blood	2.43E-02	1.81E-01	1.58E+00
Behcet's disease	4A62	Peripheral blood	3.76E-01	-5.87E-02	-2.93E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	8.57E-01	-3.86E-02	-3.54E-01
Bladder cancer	2C94	Bladder tissue	4.49E-03	5.00E-01	1.91E+00
Breast cancer	2C60-2C6Z	Breast tissue	5.43E-01	-6.32E-02	-3.17E-01
Cardioembolic stroke	8B11.20	Whole blood	3.33E-04	1.12E-01	1.05E+00
Cervical cancer	2C77	Cervical tissue	6.33E-01	-1.28E-02	-4.68E-02
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	9.68E-01	-6.44E-03	-3.70E-02
Chronic hepatitis C	1E51.1	Whole blood	9.77E-01	3.73E-02	2.12E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	6.50E-02	5.33E-02	3.04E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	9.39E-01	-1.20E-02	-9.29E-02
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	8.41E-01	-8.86E-03	-1.08E-01
Colon cancer	2B90	Colon tissue	2.89E-01	-6.69E-02	-3.65E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	4.76E-01	-9.53E-02	-4.83E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	2.58E-01	-4.50E-02	-2.62E-01
Endometriosis	GA10	Endometrium tissue	1.32E-03	1.07E-01	7.30E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	3.65E-01	8.07E-03	7.40E-02
Familial hypercholesterolemia	5C80.00	Whole blood	1.32E-01	-6.51E-02	-2.98E-01
Gastric cancer	2B72	Gastric tissue	8.30E-01	-1.25E-01	-6.69E-01
Glioblastopma	2A00.00	Nervous tissue	1.87E-01	-1.71E-02	-8.56E-02
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	4.56E-01	-1.58E-03	-2.78E-02
Glioma	2A00.0Y-2A00.0Z	White matter tissue	8.03E-03	-3.03E-01	-8.66E-01
Head and neck cancer	2D42	Head and neck tissue	3.79E-01	-1.59E-02	-1.20E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	9.27E-02	-2.17E-03	-7.94E-03
Huntington's disease	8A01.10	Whole blood	4.68E-03	1.08E-01	1.41E+00
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	8.07E-02	-2.88E-01	-1.05E+00
Immunodeficiency	4A00-4A20	Peripheral blood	1.60E-01	1.01E-01	9.41E-01
Influenza	1E30	Whole blood	9.98E-01	4.36E-02	2.99E-01
Interstitial cystitis	GC00.3	Bladder tissue	5.79E-01	-8.24E-02	-5.13E-01
Intracranial aneurysm	8B01.0	Intracranial artery	2.10E-02	-8.08E-02	-5.05E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	1.85E-01	3.91E-02	9.82E-02
Ischemic stroke	8B11	Peripheral blood	2.51E-01	-1.09E-02	-7.99E-02
Juvenile idiopathic arthritis	FA24	Peripheral blood	1.50E-01	4.58E-02	2.47E-01
Lateral sclerosis	8B60.4	Skin	6.74E-01	-7.02E-02	-5.08E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	4.48E-01	-1.03E-03	-5.91E-03
Liver cancer	2C12.0	Liver tissue	9.81E-41	-1.71E+00	-3.14E+00
Liver failure	DB99.7-DB99.8	Liver tissue	1.29E-03	-4.20E+00	-1.01E+01
Lung cancer	2C25	Lung tissue	1.65E-26	8.98E-02	4.13E-01
Lupus erythematosus	4A40	Whole blood	2.63E-01	-6.78E-02	-1.90E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	1.38E-01	-3.09E-02	-3.21E-01
Major depressive disorder	6A70-6A7Z	Whole blood	4.70E-01	3.26E-02	1.72E-01
Melanoma	2C30	Skin	1.79E-05	-3.90E-01	-6.44E-01
Multiple myeloma	2A83.1	Peripheral blood	2.13E-01	9.14E-02	6.03E-01
Multiple myeloma	2A83.1	Bone marrow	3.03E-04	-5.54E-01	-2.48E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	8.47E-01	4.70E-03	2.10E-02
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	3.51E-02	3.77E-02	3.82E-01
Myelofibrosis	2A20.2	Whole blood	1.61E-01	6.48E-02	5.87E-01
Myocardial infarction	BA41-BA50	Peripheral blood	7.72E-02	2.30E-01	4.66E-01
Myopathy	8C70.6	Muscle tissue	8.52E-01	-1.83E-02	-2.09E-01
Neonatal sepsis	KA60	Whole blood	4.05E-01	4.59E-03	1.94E-02
Neuroectodermal tumour	2A00.11	Brain stem tissue	1.80E-03	-2.92E-01	-1.27E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	4.09E-01	1.34E-01	2.12E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	1.94E-01	6.74E-02	8.36E-01
Olive pollen allergy	CA08.00	Peripheral blood	1.97E-01	6.06E-02	4.39E-01
Oral cancer	2B6E	Oral tissue	2.42E-03	-1.50E-01	-7.60E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	2.17E-01	6.78E-03	3.67E-02
Osteoporosis	FB83.1	Bone marrow	2.87E-02	3.12E-01	6.23E+00
Ovarian cancer	2C73	Ovarian tissue	1.24E-01	-2.76E-01	-3.80E-01
Pancreatic cancer	2C10	Pancreas	7.47E-01	-2.15E-01	-9.30E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	6.73E-01	-1.29E-02	-1.08E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	9.13E-01	5.59E-03	5.63E-02
Pituitary cancer	2D12	Pituitary tissue	6.39E-01	-1.26E-01	-2.37E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	3.24E-01	-4.10E-02	-6.42E-02
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	1.24E-01	6.23E-02	6.47E-01
Polycythemia vera	2A20.4	Whole blood	1.39E-06	1.16E-01	1.10E+00
Pompe disease	5C51.3	Biceps muscle	3.32E-02	-1.30E-01	-9.42E-01
Preterm birth	KA21.4Z	Myometrium	2.27E-01	8.65E-02	7.72E-01
Prostate cancer	2C82	Prostate	1.39E-01	-4.30E-01	-5.32E-01
Psoriasis	EA90	Skin	4.61E-05	8.98E-02	3.44E-01
Rectal cancer	2B92	Rectal colon tissue	4.33E-01	-3.56E-02	-2.03E-01
Renal cancer	2C90-2C91	Kidney	7.38E-02	-2.49E-01	-1.31E+00
Retinoblastoma	2D02.2	Uvea	9.38E-01	4.16E-02	2.90E-01
Rheumatoid arthritis	FA20	Synovial tissue	2.61E-02	-1.47E-01	-7.36E-01
Rhinovirus infection	CA42.1	Nasal epithelium tissue	7.68E-01	-1.66E-03	-1.42E-02
Schizophrenia	6A20	Prefrontal cortex	6.94E-01	-1.38E-02	-5.85E-02
Schizophrenia	6A20	Superior temporal cortex	1.35E-01	-8.43E-02	-8.43E-01
Scleroderma	4A42.Z	Whole blood	7.47E-01	-2.22E-02	-1.95E-01
Seizure	8A60-8A6Z	Whole blood	5.63E-01	-9.91E-02	-5.49E-01
Sensitive skin	EK0Z	Skin	7.99E-01	-3.86E-02	-3.95E-01
Sepsis with septic shock	1G41	Whole blood	9.15E-01	8.33E-04	3.12E-03
Shwachman-Diamond syndrome	3A70.0	Bone marrow	1.16E-01	3.11E-01	1.01E+00
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	7.90E-01	1.39E-02	1.25E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	5.85E-01	5.33E-02	5.10E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	1.56E-01	6.36E-02	5.62E-01
Skin cancer	2C30-2C3Z	Skin	2.42E-12	-2.02E-01	-5.80E-01
Thrombocythemia	3B63	Whole blood	6.16E-03	8.06E-02	7.50E-01
Thrombocytopenia	3B64	Whole blood	5.11E-01	6.99E-03	5.28E-02
Thyroid cancer	2D10	Thyroid	8.41E-01	2.12E-02	7.80E-02
Tibial muscular dystrophy	8C75	Muscle tissue	3.31E-01	2.51E-02	2.39E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	3.21E-01	9.86E-02	5.76E-01
Type 2 diabetes	5A11	Liver tissue	1.36E-01	2.67E-01	1.12E+00
Ureter cancer	2C92	Urothelium	1.17E-01	2.31E-01	1.15E+00
Uterine cancer	2C78	Endometrium tissue	2.81E-06	1.14E-01	5.27E-01
Vitiligo	ED63.0	Skin	5.15E-01	-1.29E-01	-4.31E-01