Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DESYL1F)

• DME Name: Glutamate-cysteine ligase catalytic (GCLC) DME Info
• Gene Name: GCLC

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	1.32E-09	-5.98E-01	-8.35E-01
Alopecia	ED70	Skin from scalp	1.83E-06	-2.91E-01	-1.19E+00
Alzheimer's disease	8A20	Entorhinal cortex	6.26E-01	-2.58E-03	-7.03E-03
Ankylosing spondylitis	FA92.0	Pheripheral blood	6.33E-01	-3.75E-02	-1.36E-01
Aortic stenosis	BB70	Calcified aortic valve	6.67E-01	-3.25E-01	-4.13E-01
Apnea	7A40	Hyperplastic tonsil	5.08E-03	-1.26E+00	-1.73E+00
Arthropathy	FA00-FA5Z	Peripheral blood	6.67E-01	-3.76E-02	-1.22E-01
Asthma	CA23	Nasal and bronchial airway	1.06E-01	1.11E-01	1.17E-01
Atopic dermatitis	EA80	Skin	1.17E-02	-2.62E-01	-1.03E+00
Autism	6A02	Whole blood	7.23E-01	-4.33E-02	-1.35E-01
Autoimmune uveitis	9A96	Peripheral monocyte	1.27E-01	-1.27E-01	-3.68E-01
Autosomal dominant monocytopenia	4B04	Whole blood	5.96E-01	1.46E-01	3.66E-01
Bacterial infection of gingival	1C1H	Gingival tissue	2.72E-01	8.27E-02	1.94E-01
Batten disease	5C56.1	Whole blood	9.10E-01	-1.20E-01	-7.10E-01
Behcet's disease	4A62	Peripheral blood	9.07E-01	-6.93E-02	-2.06E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	9.09E-01	7.96E-03	3.85E-02
Bladder cancer	2C94	Bladder tissue	3.62E-05	-1.13E+00	-2.54E+00
Breast cancer	2C60-2C6Z	Breast tissue	2.47E-10	-4.14E-01	-4.73E-01
Cardioembolic stroke	8B11.20	Whole blood	1.16E-06	4.22E-01	1.75E+00
Cervical cancer	2C77	Cervical tissue	3.39E-01	-1.72E-03	-3.68E-03
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	9.41E-01	2.32E-02	2.53E-02
Chronic hepatitis C	1E51.1	Whole blood	7.08E-01	3.47E-02	1.20E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	8.34E-01	-3.04E-03	-1.02E-02
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	3.53E-01	-3.05E-02	-5.86E-02
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	3.17E-02	-1.28E+00	-1.04E+00
Colon cancer	2B90	Colon tissue	5.14E-02	3.02E-02	9.45E-02
Coronary artery disease	BA80-BA8Z	Peripheral blood	1.77E-02	1.42E-01	2.13E+00
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	6.53E-01	6.86E-02	8.94E-02
Endometriosis	GA10	Endometrium tissue	3.41E-02	-3.34E-01	-3.27E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	6.05E-01	-4.56E-02	-1.41E-01
Familial hypercholesterolemia	5C80.00	Whole blood	1.83E-01	3.31E-01	7.26E-01
Gastric cancer	2B72	Gastric tissue	9.76E-01	-4.44E-02	-7.20E-02
Glioblastopma	2A00.00	Nervous tissue	1.72E-08	2.04E-01	4.14E-01
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	6.25E-01	-1.96E-01	-7.64E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	5.57E-05	-1.01E+00	-2.02E+00
Head and neck cancer	2D42	Head and neck tissue	8.76E-05	-1.61E-01	-1.18E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	7.04E-01	9.66E-02	1.54E-01
Huntington's disease	8A01.10	Whole blood	4.38E-01	-2.91E-01	-8.85E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	6.32E-01	2.11E-01	4.79E-01
Immunodeficiency	4A00-4A20	Peripheral blood	9.68E-02	-1.02E-01	-9.54E-01
Influenza	1E30	Whole blood	6.20E-03	-6.93E-01	-4.41E+00
Interstitial cystitis	GC00.3	Bladder tissue	1.48E-04	-1.84E+00	-4.41E+00
Intracranial aneurysm	8B01.0	Intracranial artery	3.37E-02	3.36E-01	5.37E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	6.71E-01	1.65E-02	6.52E-02
Ischemic stroke	8B11	Peripheral blood	4.46E-01	1.89E-02	8.05E-02
Juvenile idiopathic arthritis	FA24	Peripheral blood	1.24E-02	4.89E-02	1.21E-01
Lateral sclerosis	8B60.4	Skin	9.34E-01	1.45E-01	3.75E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	5.58E-02	-8.08E-01	-8.92E-01
Liver cancer	2C12.0	Liver tissue	2.03E-06	-4.17E-01	-7.65E-01
Liver failure	DB99.7-DB99.8	Liver tissue	4.64E-04	-1.02E+00	-2.87E+00
Lung cancer	2C25	Lung tissue	6.97E-77	1.02E+00	2.21E+00
Lupus erythematosus	4A40	Whole blood	3.22E-02	-1.28E-01	-3.42E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	6.23E-01	-1.86E-02	-9.27E-02
Major depressive disorder	6A70-6A7Z	Whole blood	7.02E-01	2.11E-02	5.30E-02
Melanoma	2C30	Skin	1.24E-04	-3.51E-01	-9.54E-01
Multiple myeloma	2A83.1	Peripheral blood	4.18E-01	-1.37E-01	-2.76E-01
Multiple myeloma	2A83.1	Bone marrow	7.76E-03	5.00E-01	1.44E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	1.06E-01	-6.50E-01	-1.33E+00
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	3.95E-05	2.22E-01	7.90E-01
Myelofibrosis	2A20.2	Whole blood	1.60E-02	1.26E+00	4.33E+00
Myocardial infarction	BA41-BA50	Peripheral blood	1.42E-02	-5.22E-02	-7.28E-02
Myopathy	8C70.6	Muscle tissue	6.65E-02	7.82E-02	3.17E-01
Neonatal sepsis	KA60	Whole blood	5.49E-02	4.79E-02	7.17E-02
Neuroectodermal tumour	2A00.11	Brain stem tissue	8.72E-02	5.14E-01	9.53E-01
Non-alcoholic fatty liver disease	DB92	Liver tissue	3.12E-02	1.34E-01	4.90E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	8.32E-01	1.41E-01	2.22E-01
Olive pollen allergy	CA08.00	Peripheral blood	4.01E-01	8.41E-01	6.74E-01
Oral cancer	2B6E	Oral tissue	1.43E-01	3.26E-01	2.38E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	7.71E-01	-7.84E-02	-1.18E-01
Osteoporosis	FB83.1	Bone marrow	1.38E-01	-1.58E-01	-3.58E-01
Ovarian cancer	2C73	Ovarian tissue	5.60E-01	7.02E-01	5.17E-01
Pancreatic cancer	2C10	Pancreas	9.00E-01	-1.84E-01	-2.68E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	7.72E-01	4.55E-03	1.06E-02
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	1.49E-02	5.56E-02	2.55E-01
Pituitary cancer	2D12	Pituitary tissue	9.26E-09	1.30E+00	3.32E+00
Pituitary gonadotrope tumour	2D12	Pituitary tissue	1.21E-07	1.99E+00	4.15E+00
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	4.91E-01	3.82E-02	1.61E-01
Polycythemia vera	2A20.4	Whole blood	5.97E-02	8.43E-02	2.81E-01
Pompe disease	5C51.3	Biceps muscle	8.44E-03	5.15E-01	1.41E+00
Preterm birth	KA21.4Z	Myometrium	4.63E-01	3.56E-01	5.02E-01
Prostate cancer	2C82	Prostate	2.43E-06	-3.79E-01	-7.61E-01
Psoriasis	EA90	Skin	1.40E-02	1.24E-01	3.02E-01
Rectal cancer	2B92	Rectal colon tissue	1.49E-01	1.27E-01	5.26E-01
Renal cancer	2C90-2C91	Kidney	1.05E-03	6.27E-01	1.21E+00
Retinoblastoma	2D02.2	Uvea	7.43E-04	7.74E-01	3.77E+00
Rheumatoid arthritis	FA20	Synovial tissue	5.86E-01	-9.54E-02	-1.38E-01
Rhinovirus infection	CA42.1	Nasal epithelium tissue	7.46E-03	-1.74E-01	-5.34E-01
Schizophrenia	6A20	Prefrontal cortex	1.62E-01	-9.03E-02	-2.32E-01
Schizophrenia	6A20	Superior temporal cortex	7.85E-02	-1.17E-01	-5.16E-01
Scleroderma	4A42.Z	Whole blood	9.14E-01	4.97E-02	1.61E-01
Seizure	8A60-8A6Z	Whole blood	2.70E-02	-1.79E-01	-2.62E-01
Sensitive skin	EK0Z	Skin	3.64E-01	-1.93E-03	-1.97E-02
Sepsis with septic shock	1G41	Whole blood	2.70E-01	-2.71E-01	-5.63E-01
Shwachman-Diamond syndrome	3A70.0	Bone marrow	7.37E-03	8.32E-01	2.92E+00
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	1.95E-02	-3.11E-01	-4.76E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	4.32E-01	-8.82E-02	-2.74E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	4.94E-05	8.82E-01	7.04E+00
Skin cancer	2C30-2C3Z	Skin	2.40E-19	-3.11E-01	-8.53E-01
Thrombocythemia	3B63	Whole blood	5.07E-02	-1.61E-01	-5.54E-01
Thrombocytopenia	3B64	Whole blood	1.91E-01	-1.19E+00	-1.04E+00
Thyroid cancer	2D10	Thyroid	2.07E-06	-3.63E-01	-1.03E+00
Tibial muscular dystrophy	8C75	Muscle tissue	8.21E-01	-9.82E-02	-3.37E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	7.26E-01	-1.53E-01	-1.87E+00
Type 2 diabetes	5A11	Liver tissue	4.35E-02	1.91E-01	6.69E-01
Ureter cancer	2C92	Urothelium	6.95E-01	1.22E-01	2.06E-01
Uterine cancer	2C78	Endometrium tissue	1.72E-01	-8.61E-02	-7.51E-02
Vitiligo	ED63.0	Skin	7.66E-01	6.63E-03	3.72E-02