Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DEUP4DA)

• DME Name: Thioredoxin reductase TR1 (TXNRD1) DME Info
• Gene Name: TXNRD1

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	6.07E-05	1.21E-01	5.58E-01
Alopecia	ED70	Skin from scalp	3.07E-08	-4.23E-01	-1.38E+00
Alzheimer's disease	8A20	Entorhinal cortex	4.61E-01	7.08E-03	5.11E-02
Ankylosing spondylitis	FA92.0	Pheripheral blood	3.07E-01	8.82E-02	3.79E-01
Aortic stenosis	BB70	Calcified aortic valve	3.21E-01	-1.70E-01	-2.93E-01
Apnea	7A40	Hyperplastic tonsil	1.94E-02	6.97E-01	2.39E+00
Arthropathy	FA00-FA5Z	Peripheral blood	2.49E-02	1.62E-01	1.42E+00
Asthma	CA23	Nasal and bronchial airway	8.26E-07	2.17E-01	5.38E-01
Atopic dermatitis	EA80	Skin	2.28E-02	-7.77E-02	-1.87E+00
Autism	6A02	Whole blood	9.56E-02	2.59E-02	1.31E-01
Autoimmune uveitis	9A96	Peripheral monocyte	1.18E-01	7.32E-02	4.35E-01
Autosomal dominant monocytopenia	4B04	Whole blood	2.37E-01	4.31E-01	1.44E+00
Bacterial infection of gingival	1C1H	Gingival tissue	2.25E-15	2.86E-01	1.47E+00
Batten disease	5C56.1	Whole blood	9.92E-01	4.83E-03	4.81E-02
Behcet's disease	4A62	Peripheral blood	8.15E-01	-1.80E-02	-9.44E-02
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	8.66E-01	5.01E-03	5.80E-02
Bladder cancer	2C94	Bladder tissue	8.21E-02	-1.38E-01	-3.05E-01
Breast cancer	2C60-2C6Z	Breast tissue	6.55E-06	7.49E-02	2.23E-01
Cardioembolic stroke	8B11.20	Whole blood	8.83E-03	8.23E-02	5.81E-01
Cervical cancer	2C77	Cervical tissue	3.89E-06	2.69E-01	1.47E+00
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	7.59E-01	2.02E-04	6.09E-04
Chronic hepatitis C	1E51.1	Whole blood	4.04E-01	1.30E-01	5.95E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	7.31E-01	-1.62E-02	-7.85E-02
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	2.24E-04	1.42E-01	4.36E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	1.61E-01	-1.57E-01	-8.46E-01
Colon cancer	2B90	Colon tissue	9.26E-01	9.84E-03	5.28E-02
Coronary artery disease	BA80-BA8Z	Peripheral blood	9.19E-01	-2.06E-02	-6.21E-02
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	8.04E-01	1.01E-01	2.86E-01
Endometriosis	GA10	Endometrium tissue	1.99E-01	2.44E-01	3.46E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	6.39E-01	-3.05E-02	-2.12E-01
Familial hypercholesterolemia	5C80.00	Whole blood	4.02E-04	2.15E-01	1.34E+00
Gastric cancer	2B72	Gastric tissue	1.01E-01	2.91E-01	1.22E+00
Glioblastopma	2A00.00	Nervous tissue	4.04E-45	1.91E-01	8.05E-01
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	6.30E-01	-1.41E-01	-1.08E+00
Glioma	2A00.0Y-2A00.0Z	White matter tissue	2.41E-01	1.90E-02	4.49E-02
Head and neck cancer	2D42	Head and neck tissue	4.49E-01	2.20E-01	2.91E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	6.79E-01	-8.46E-03	-5.01E-02
Huntington's disease	8A01.10	Whole blood	8.66E-01	3.49E-02	1.36E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	9.65E-03	-6.19E-01	-1.80E+00
Immunodeficiency	4A00-4A20	Peripheral blood	9.96E-05	1.72E-01	2.89E+00
Influenza	1E30	Whole blood	8.47E-02	-6.84E-01	-1.70E+00
Interstitial cystitis	GC00.3	Bladder tissue	2.25E-01	2.15E-01	7.94E-01
Intracranial aneurysm	8B01.0	Intracranial artery	6.29E-01	-2.54E-02	-1.17E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	8.76E-02	7.47E-02	2.23E-01
Ischemic stroke	8B11	Peripheral blood	6.85E-03	-1.23E-01	-1.48E+00
Juvenile idiopathic arthritis	FA24	Peripheral blood	5.11E-01	6.82E-02	1.34E-01
Lateral sclerosis	8B60.4	Skin	6.03E-01	-6.92E-02	-2.59E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	6.64E-01	6.01E-02	1.45E-01
Liver cancer	2C12.0	Liver tissue	1.75E-19	5.20E-01	1.77E+00
Liver failure	DB99.7-DB99.8	Liver tissue	9.19E-01	8.14E-02	3.32E-01
Lung cancer	2C25	Lung tissue	5.07E-23	1.88E-01	8.14E-01
Lupus erythematosus	4A40	Whole blood	8.08E-03	1.49E-01	4.62E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	8.24E-02	4.84E-02	5.90E-01
Major depressive disorder	6A70-6A7Z	Whole blood	8.53E-03	7.86E-02	4.66E-01
Melanoma	2C30	Skin	5.49E-01	2.15E-01	3.67E-01
Multiple myeloma	2A83.1	Peripheral blood	2.20E-01	-1.38E-01	-4.40E-01
Multiple myeloma	2A83.1	Bone marrow	4.64E-06	3.60E-01	3.81E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	1.59E-01	-2.58E-01	-1.04E+00
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	2.33E-01	-3.63E-02	-2.40E-01
Myelofibrosis	2A20.2	Whole blood	2.06E-01	-5.50E-02	-4.17E-01
Myocardial infarction	BA41-BA50	Peripheral blood	4.49E-01	-4.44E-02	-1.25E-01
Myopathy	8C70.6	Muscle tissue	3.75E-01	1.92E-01	7.14E-01
Neonatal sepsis	KA60	Whole blood	2.93E-17	2.89E-01	1.50E+00
Neuroectodermal tumour	2A00.11	Brain stem tissue	6.07E-07	7.64E-01	3.49E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	4.77E-01	1.12E-01	3.94E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	4.26E-01	-3.37E-01	-6.76E-01
Olive pollen allergy	CA08.00	Peripheral blood	4.21E-01	-1.39E-01	-7.43E-01
Oral cancer	2B6E	Oral tissue	7.00E-12	6.36E-01	1.74E+00
Osteoarthritis	FA00-FA0Z	Synovial tissue	1.42E-01	2.01E-01	4.79E-01
Osteoporosis	FB83.1	Bone marrow	7.55E-01	3.22E-02	1.49E-01
Ovarian cancer	2C73	Ovarian tissue	2.92E-01	2.47E-01	6.10E-01
Pancreatic cancer	2C10	Pancreas	1.05E-03	2.74E-01	1.13E+00
Parkinson's disease	8A00.0	Substantia nigra tissue	3.04E-01	2.02E-02	7.71E-02
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	9.11E-04	1.20E-01	1.09E+00
Pituitary cancer	2D12	Pituitary tissue	6.56E-01	1.49E-02	7.90E-02
Pituitary gonadotrope tumour	2D12	Pituitary tissue	4.52E-01	-3.05E-02	-2.26E-01
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	1.87E-01	-8.54E-02	-6.00E-01
Polycythemia vera	2A20.4	Whole blood	4.06E-02	6.80E-02	4.97E-01
Pompe disease	5C51.3	Biceps muscle	7.90E-01	-1.73E-02	-1.42E-01
Preterm birth	KA21.4Z	Myometrium	3.19E-03	6.11E-01	2.68E+00
Prostate cancer	2C82	Prostate	2.13E-01	3.26E-01	6.20E-01
Psoriasis	EA90	Skin	1.87E-30	4.09E-01	2.10E+00
Rectal cancer	2B92	Rectal colon tissue	9.56E-01	1.18E-02	1.17E-01
Renal cancer	2C90-2C91	Kidney	4.81E-03	3.64E-01	1.05E+00
Retinoblastoma	2D02.2	Uvea	1.81E-09	4.56E-01	4.68E+00
Rheumatoid arthritis	FA20	Synovial tissue	2.35E-03	3.51E-02	1.89E-01
Rhinovirus infection	CA42.1	Nasal epithelium tissue	1.37E-01	-6.07E-02	-4.24E-01
Schizophrenia	6A20	Prefrontal cortex	1.93E-01	-2.91E-02	-1.57E-01
Schizophrenia	6A20	Superior temporal cortex	9.21E-01	-1.11E-02	-7.59E-02
Scleroderma	4A42.Z	Whole blood	5.52E-03	5.31E-02	5.87E-01
Seizure	8A60-8A6Z	Whole blood	3.15E-02	-2.17E-01	-1.08E+00
Sensitive skin	EK0Z	Skin	9.21E-01	2.29E-02	2.96E-01
Sepsis with septic shock	1G41	Whole blood	1.57E-38	2.77E-01	1.41E+00
Shwachman-Diamond syndrome	3A70.0	Bone marrow	1.12E-01	-1.73E-01	-1.09E+00
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	9.48E-01	-5.03E-02	-1.47E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	5.59E-01	-5.39E-02	-3.23E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	2.11E-01	2.89E-01	1.20E+00
Skin cancer	2C30-2C3Z	Skin	1.24E-50	5.49E-01	2.26E+00
Thrombocythemia	3B63	Whole blood	4.04E-01	-7.01E-02	-5.29E-01
Thrombocytopenia	3B64	Whole blood	3.74E-01	-4.80E-01	-7.18E-01
Thyroid cancer	2D10	Thyroid	1.20E-05	-1.59E-01	-8.41E-01
Tibial muscular dystrophy	8C75	Muscle tissue	9.40E-05	-2.71E-01	-1.69E+00
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	4.34E-01	-9.80E-02	-9.97E-01
Type 2 diabetes	5A11	Liver tissue	7.78E-01	-1.11E-02	-1.69E-01
Ureter cancer	2C92	Urothelium	6.44E-01	-4.53E-02	-6.33E-02
Uterine cancer	2C78	Endometrium tissue	1.08E-19	3.60E-01	1.03E+00
Vitiligo	ED63.0	Skin	5.97E-01	-6.18E-03	-6.76E-02