Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DEZDRQO)

• DME Name: Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info
• Gene Name: HSD11B1

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	5.56E-02	-5.91E-02	-2.68E-01
Alopecia	ED70	Skin from scalp	4.38E-03	2.11E-01	2.68E-01
Alzheimer's disease	8A20	Entorhinal cortex	1.64E-01	1.14E-01	1.66E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	6.90E-01	-2.96E-01	-5.03E-01
Aortic stenosis	BB70	Calcified aortic valve	7.79E-01	9.47E-02	5.75E-02
Apnea	7A40	Hyperplastic tonsil	5.85E-01	-8.19E-02	-1.55E-01
Arthropathy	FA00-FA5Z	Peripheral blood	6.51E-03	1.03E-01	8.54E-01
Asthma	CA23	Nasal and bronchial airway	1.60E-04	1.07E-01	2.03E-01
Atopic dermatitis	EA80	Skin	2.65E-08	-2.52E+00	-2.90E+00
Autism	6A02	Whole blood	9.92E-01	-5.65E-02	-3.31E-01
Autoimmune uveitis	9A96	Peripheral monocyte	4.97E-01	-1.13E-01	-8.95E-01
Autosomal dominant monocytopenia	4B04	Whole blood	4.16E-01	2.48E-03	2.38E-02
Bacterial infection of gingival	1C1H	Gingival tissue	8.16E-17	1.10E+00	1.76E+00
Batten disease	5C56.1	Whole blood	9.57E-01	3.38E-02	1.43E-01
Behcet's disease	4A62	Peripheral blood	3.74E-01	8.89E-02	3.51E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	6.74E-01	-8.58E-02	-1.80E-01
Bladder cancer	2C94	Bladder tissue	1.60E-01	-8.07E-01	-7.57E-01
Breast cancer	2C60-2C6Z	Breast tissue	1.22E-47	-1.80E+00	-1.25E+00
Cardioembolic stroke	8B11.20	Whole blood	1.06E-01	-1.25E-01	-2.95E-01
Cervical cancer	2C77	Cervical tissue	2.47E-04	4.00E-01	1.10E+00
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	8.42E-01	-5.89E-04	-3.07E-03
Chronic hepatitis C	1E51.1	Whole blood	9.53E-01	-2.50E-02	-1.18E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	6.08E-01	2.78E-02	5.03E-02
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	4.19E-03	1.58E-01	5.83E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	2.05E-01	1.07E-01	9.04E-01
Colon cancer	2B90	Colon tissue	3.31E-53	6.87E-01	1.44E+00
Coronary artery disease	BA80-BA8Z	Peripheral blood	3.07E-01	-5.60E-02	-2.26E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	7.92E-01	-7.17E-03	-3.57E-02
Endometriosis	GA10	Endometrium tissue	5.48E-05	6.21E-01	6.05E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	3.53E-01	1.12E-01	5.57E-01
Familial hypercholesterolemia	5C80.00	Whole blood	1.35E-01	-1.64E-01	-7.86E-01
Gastric cancer	2B72	Gastric tissue	2.36E-01	1.20E+00	1.14E+00
Glioblastopma	2A00.00	Nervous tissue	1.20E-78	-1.42E+00	-1.47E+00
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	6.53E-01	-3.44E-01	-7.31E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	1.02E-01	9.67E-01	1.19E+00
Head and neck cancer	2D42	Head and neck tissue	1.89E-06	6.38E-01	7.03E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	1.28E-01	-3.97E-01	-7.44E-01
Huntington's disease	8A01.10	Whole blood	7.72E-01	-2.99E-04	-2.33E-03
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	3.22E-02	-8.49E-01	-1.20E+00
Immunodeficiency	4A00-4A20	Peripheral blood	3.55E-01	1.54E-01	6.35E-01
Influenza	1E30	Whole blood	8.47E-01	-4.76E-01	-5.91E-01
Interstitial cystitis	GC00.3	Bladder tissue	1.03E-02	1.91E+00	1.73E+00
Intracranial aneurysm	8B01.0	Intracranial artery	3.52E-01	1.04E+00	1.71E+00
Irritable bowel syndrome	DD91.0	Rectal colon tissue	7.64E-01	2.60E-02	4.28E-02
Ischemic stroke	8B11	Peripheral blood	1.12E-01	1.26E-01	4.38E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	9.09E-01	-2.49E-02	-8.11E-02
Lateral sclerosis	8B60.4	Skin	2.46E-01	-2.06E-01	-5.64E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	2.10E-01	-2.06E-01	-5.91E-01
Liver cancer	2C12.0	Liver tissue	5.81E-30	-1.73E+00	-2.51E+00
Liver failure	DB99.7-DB99.8	Liver tissue	7.26E-07	-2.92E+00	-7.62E+00
Lung cancer	2C25	Lung tissue	1.53E-68	-1.15E+00	-1.81E+00
Lupus erythematosus	4A40	Whole blood	4.48E-02	-8.91E-02	-2.44E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	3.36E-01	1.12E-01	2.38E-01
Major depressive disorder	6A70-6A7Z	Whole blood	2.71E-01	2.69E-02	9.87E-02
Melanoma	2C30	Skin	1.28E-03	-3.49E+00	-1.39E+00
Multiple myeloma	2A83.1	Peripheral blood	5.27E-01	4.52E-02	2.93E-01
Multiple myeloma	2A83.1	Bone marrow	2.79E-05	2.30E-01	1.83E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	4.13E-01	1.24E-01	4.85E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	1.38E-01	2.27E-02	1.12E-01
Myelofibrosis	2A20.2	Whole blood	8.39E-01	-4.86E-02	-3.15E-01
Myocardial infarction	BA41-BA50	Peripheral blood	2.35E-07	-6.79E-01	-7.07E-01
Myopathy	8C70.6	Muscle tissue	4.35E-01	-1.85E-01	-5.55E-01
Neonatal sepsis	KA60	Whole blood	9.86E-03	7.04E-02	2.85E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	1.92E-07	-1.30E+00	-3.48E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	8.61E-01	1.05E-01	2.75E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	8.99E-01	-1.11E-01	-1.19E-01
Olive pollen allergy	CA08.00	Peripheral blood	7.32E-01	-1.75E-01	-3.04E-01
Oral cancer	2B6E	Oral tissue	3.60E-01	7.34E-02	1.28E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	5.68E-01	1.38E-02	2.46E-02
Osteoporosis	FB83.1	Bone marrow	5.82E-01	-8.54E-02	-1.60E-01
Ovarian cancer	2C73	Ovarian tissue	2.14E-03	-2.18E+00	-1.51E+00
Pancreatic cancer	2C10	Pancreas	2.85E-01	5.09E-01	5.64E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	4.81E-01	4.09E-01	4.15E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	9.05E-02	3.89E-02	1.91E-01
Pituitary cancer	2D12	Pituitary tissue	8.76E-11	-2.21E+00	-4.28E+00
Pituitary gonadotrope tumour	2D12	Pituitary tissue	2.82E-07	-2.91E+00	-5.44E+00
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	9.18E-01	-4.92E-02	-2.49E-01
Polycythemia vera	2A20.4	Whole blood	2.61E-05	7.61E-02	5.00E-01
Pompe disease	5C51.3	Biceps muscle	2.27E-01	-6.28E-01	-1.15E+00
Preterm birth	KA21.4Z	Myometrium	3.21E-01	-2.72E-01	-2.00E-01
Prostate cancer	2C82	Prostate	6.32E-02	2.20E-01	1.37E-01
Psoriasis	EA90	Skin	1.58E-50	-2.36E+00	-3.65E+00
Rectal cancer	2B92	Rectal colon tissue	2.80E-01	1.03E-01	1.63E-01
Renal cancer	2C90-2C91	Kidney	8.61E-02	-1.36E+00	-1.23E+00
Retinoblastoma	2D02.2	Uvea	2.66E-01	-2.65E-01	-4.33E-01
Rheumatoid arthritis	FA20	Synovial tissue	1.08E-03	5.67E-01	1.18E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	1.57E-02	1.80E-02	9.04E-02
Schizophrenia	6A20	Prefrontal cortex	4.13E-02	-3.92E-01	-4.32E-01
Schizophrenia	6A20	Superior temporal cortex	4.70E-04	-4.62E-01	-1.06E+00
Scleroderma	4A42.Z	Whole blood	3.34E-04	-3.18E-01	-2.24E+00
Seizure	8A60-8A6Z	Whole blood	9.31E-01	-2.31E-02	-1.24E-01
Sensitive skin	EK0Z	Skin	2.77E-01	-2.87E-01	-9.42E-01
Sepsis with septic shock	1G41	Whole blood	1.03E-11	1.43E-01	6.50E-01
Shwachman-Diamond syndrome	3A70.0	Bone marrow	1.08E-01	2.13E-01	7.71E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	2.96E-01	2.13E-01	8.97E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	6.25E-01	3.02E-01	6.55E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	4.49E-03	4.47E-01	2.46E+00
Skin cancer	2C30-2C3Z	Skin	1.14E-133	-3.23E+00	-3.48E+00
Thrombocythemia	3B63	Whole blood	1.28E-01	1.37E-01	8.91E-01
Thrombocytopenia	3B64	Whole blood	4.80E-01	3.46E-01	5.77E-01
Thyroid cancer	2D10	Thyroid	9.15E-01	-2.13E-01	-2.94E-01
Tibial muscular dystrophy	8C75	Muscle tissue	1.14E-02	-7.86E-01	-1.01E+00
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	1.60E-03	-1.66E+00	-4.10E+00
Type 2 diabetes	5A11	Liver tissue	2.03E-01	-1.24E-02	-8.14E-02
Ureter cancer	2C92	Urothelium	6.48E-01	1.95E-02	1.07E-01
Uterine cancer	2C78	Endometrium tissue	9.46E-10	4.90E-01	6.91E-01
Vitiligo	ED63.0	Skin	6.56E-01	-1.59E-01	-2.55E-01