Details of the Drug-Related molecule(s) Expression Atlas

General Information of DTP (ID: DT6MDC9)

• DTP Name: Thiazide-sensitive sodium-chloride cotransporter (SLC12A3) DTP Info
• Gene Name: NCC

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	6.90E-04	-1.14E-01	-4.47E-01
Adrenocortical carcinoma	2D11.Z	Kidney	8.66E-01	-2.54E-02	-1.29E-01
Alopecia	ED70	Skin from scalp	3.55E-01	3.10E-03	1.96E-02
Alzheimer's disease	8A20	Entorhinal cortex	1.28E-01	-5.80E-02	-3.34E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	6.37E-02	-1.03E-01	-8.58E-01
Aortic stenosis	BB70	Calcified aortic valve	7.10E-01	-1.40E-01	-2.99E-01
Apnea	7A40	Hyperplastic tonsil	1.73E-02	-2.02E-01	-1.36E+00
Arthropathy	FA00-FA5Z	Peripheral blood	4.18E-01	5.97E-02	4.55E-01
Asthma	CA23	Nasal and bronchial airway	1.28E-02	-9.50E-02	-3.99E-01
Atopic dermatitis	EA80	Skin	8.88E-02	5.39E-02	6.84E-01
Autism	6A02	Whole blood	3.35E-02	-1.23E-01	-5.95E-01
Autoimmune uveitis	9A96	Peripheral monocyte	4.77E-02	-4.31E-01	-1.82E+00
Autosomal dominant monocytopenia	4B04	Whole blood	3.67E-01	-5.02E-02	-4.17E-01
Bacterial infection of gingival	1C1H	Gingival tissue	8.51E-02	5.19E-02	2.13E-01
Batten disease	5C56.1	Whole blood	8.74E-01	9.00E-03	7.54E-02
Behcet's disease	4A62	Peripheral blood	3.33E-01	1.55E-01	6.72E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	7.30E-02	-8.30E-02	-5.07E-01
Bladder cancer	2C94	Bladder tissue	5.78E-04	3.34E-01	2.10E+00
Breast cancer	2C60-2C6Z	Breast tissue	7.15E-01	2.60E-03	1.10E-02
Cardioembolic stroke	8B11.20	Whole blood	2.12E-02	1.12E-01	5.95E-01
Cervical cancer	2C77	Cervical tissue	3.71E-01	-2.21E-02	-8.83E-02
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	2.50E-01	1.06E-01	3.78E-01
Chronic hepatitis C	1E51.1	Whole blood	7.65E-01	3.63E-02	2.14E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	8.55E-03	5.79E-02	3.26E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	5.45E-02	8.19E-02	4.75E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	1.85E-01	-8.65E-02	-6.44E-01
Colon cancer	2B90	Colon tissue	6.76E-03	-2.37E-02	-1.16E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	6.31E-01	-7.99E-02	-4.01E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	2.96E-01	-3.57E-02	-1.45E-01
Endometriosis	GA10	Endometrium tissue	2.93E-01	9.48E-02	3.11E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	2.50E-01	-4.77E-02	-6.15E-01
Familial hypercholesterolemia	5C80.00	Whole blood	7.42E-04	-2.53E-01	-1.05E+00
Gastric cancer	2B72	Gastric tissue	5.21E-01	-1.80E-01	-4.51E-01
Glioblastopma	2A00.00	Nervous tissue	2.58E-10	-1.05E-01	-4.17E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	6.47E-03	-3.81E-01	-1.48E+00
Head and neck cancer	2D42	Head and neck tissue	6.04E-06	1.01E-01	6.85E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	2.85E-01	-4.62E-02	-1.14E-01
Huntington's disease	8A01.10	Whole blood	5.58E-01	5.61E-02	2.66E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	5.92E-02	-1.56E-01	-1.33E+00
Immunodeficiency	4A00-4A20	Peripheral blood	1.34E-02	8.21E-02	1.02E+00
Influenza	1.00E+30	Whole blood	5.89E-01	5.51E-02	1.97E-01
Interstitial cystitis	GC00.3	Bladder tissue	2.11E-01	2.57E-01	2.24E+00
Intracranial aneurysm	8B01.0	Intracranial artery	4.73E-01	-4.63E-03	-2.93E-02
Irritable bowel syndrome	DD91.0	Rectal colon tissue	9.78E-01	3.30E-02	1.21E-01
Ischemic stroke	8B11	Peripheral blood	5.65E-01	5.34E-02	2.60E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	3.10E-01	7.18E-02	2.68E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	6.41E-01	1.32E-02	5.23E-02
Lateral sclerosis	8B60.4	Skin	1.57E-01	1.66E-01	1.38E+00
Liver cancer	2C12.0	Liver tissue	6.85E-02	7.65E-03	3.34E-02
Liver failure	DB99.7-DB99.8	Liver tissue	9.07E-01	9.28E-02	4.57E-01
Lung cancer	2C25	Lung tissue	6.35E-03	5.51E-02	3.16E-01
Lupus erythematosus	4A40	Whole blood	3.09E-01	-8.67E-02	-1.96E-01
Major depressive disorder	6A70-6A7Z	Whole blood	8.98E-01	2.29E-02	7.89E-02
Major depressive disorder	6A70-6A7Z	Hippocampus	5.71E-01	6.96E-02	4.29E-01
Melanoma	2C30	Skin	2.79E-01	-1.23E-01	-2.82E-01
Multiple myeloma	2A83.1	Bone marrow	9.76E-05	-4.66E-01	-2.46E+00
Multiple myeloma	2A83.1	Peripheral blood	7.73E-01	-4.17E-02	-1.92E-01
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	1.12E-02	7.51E-01	1.60E+00
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	3.49E-01	4.68E-02	2.22E-01
Myelofibrosis	2A20.2	Whole blood	8.65E-02	-1.33E-01	-1.05E+00
Myocardial infarction	BA41-BA50	Peripheral blood	1.38E-01	8.06E-02	2.11E-01
Myopathy	8C70.6	Muscle tissue	2.84E-01	3.85E-02	2.49E-01
Neonatal sepsis	KA60	Whole blood	3.19E-03	-1.00E-01	-3.83E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	1.23E-02	-2.95E-01	-1.15E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	2.18E-01	-9.93E-02	-1.24E+00
Obesity related type 2 diabetes	5A11	Omental adipose tissue	5.35E-02	1.33E-01	1.03E+00
Olive pollen allergy	CA08.00	Peripheral blood	2.21E-01	1.56E-01	6.01E-01
Oral cancer	2B6E	Oral tissue	1.80E-02	-2.13E-01	-7.72E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	4.06E-03	-1.75E-01	-1.18E+00
Osteoporosis	FB83.1	Bone marrow	5.27E-01	9.82E-03	4.74E-02
Ovarian cancer	2C73	Ovarian tissue	3.29E-01	-2.49E-02	-1.60E-01
Pancreatic cancer	2C10	Pancreas	4.31E-02	-8.93E-02	-3.23E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	5.96E-01	-6.83E-02	-4.46E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	5.30E-01	-3.03E-02	-3.62E-01
Pituitary cancer	2D12	Pituitary tissue	5.36E-01	2.20E-01	6.63E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	1.53E-02	1.91E-01	1.09E+00
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	2.83E-01	8.26E-02	5.05E-01
Polycythemia vera	2A20.4	Whole blood	1.42E-01	-1.92E-02	-1.33E-01
Pompe disease	5C51.3	Biceps muscle	8.00E-01	-4.70E-02	-3.28E-01
Preterm birth	KA21.4Z	Myometrium	7.56E-01	-3.22E-02	-2.68E-01
Prostate cancer	2C82	Prostate	2.38E-02	-2.36E-01	-5.60E-01
Psoriasis	EA90	Skin	3.34E-04	9.37E-02	3.86E-01
Rectal cancer	2B92	Rectal colon tissue	9.88E-01	3.99E-02	1.73E-01
Renal cancer	2C90-2C91	Kidney	1.01E-04	-2.30E+00	-2.27E+00
Retinoblastoma	2D02.2	Uvea	4.19E-03	-1.28E-01	-2.04E+00
Rheumatoid arthritis	FA20	Synovial tissue	6.64E-01	-8.67E-02	-4.11E-01
Rhinovirus infection	CA42.1	Nasal epithelium tissue	6.51E-01	1.49E-02	9.12E-02
Schizophrenia	6A20	Prefrontal cortex	8.55E-01	-1.97E-03	-9.25E-03
Schizophrenia	6A20	Superior temporal cortex	1.94E-01	-7.13E-02	-4.72E-01
Scleroderma	4A42.Z	Whole blood	5.59E-04	3.21E-01	2.01E+00
Seizure	8A60-8A6Z	Whole blood	6.88E-01	-1.27E-01	-8.68E-01
Sensitive skin	EK0Z	Skin	6.89E-01	2.11E-02	2.79E-01
Sepsis with septic shock	1G41	Whole blood	8.71E-02	-1.78E-02	-6.87E-02
Shwachman-Diamond syndrome	3A70.0	Bone marrow	3.35E-02	3.31E-01	9.08E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	6.17E-01	1.68E-02	7.61E-02
Simpson golabi behmel syndrome	LD2C	Adipose tissue	8.68E-01	-4.16E-02	-2.20E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	8.69E-01	-9.24E-02	-3.26E-01
Skin cancer	2C30-2C3Z	Skin	1.01E-07	-1.15E-01	-3.66E-01
Thrombocythemia	3B63	Whole blood	3.15E-01	2.90E-02	2.06E-01
Thrombocytopenia	3B64	Whole blood	2.92E-03	2.62E-01	1.35E+00
Thyroid cancer	2D10	Thyroid	3.35E-05	9.32E-02	3.34E-01
Tibial muscular dystrophy	8C75	Muscle tissue	1.17E-02	-1.64E-01	-6.79E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	1.31E-01	1.04E-01	1.13E+00
Type 2 diabetes	5A11	Liver tissue	3.30E-01	-1.32E-01	-7.58E-01
Ureter cancer	2C92	Urothelium	1.34E-01	-1.12E-01	-1.10E+00
Uterine cancer	2C78	Endometrium tissue	1.28E-02	-1.01E-01	-4.20E-01
Vitiligo	ED63.0	Skin	1.18E-01	-6.66E-02	-5.45E-01