Details of the Drug-Related molecule(s) Expression Atlas

General Information of DTP (ID: DTCL4P8)

• DTP Name: Electrogenic sodium bicarbonate cotransporter 4 (SLC4A5) DTP Info
• Gene Name: NBCe2

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	1.09E-07	1.11E-01	6.17E-01
Adrenocortical carcinoma	2D11.Z	Kidney	9.31E-01	-5.86E-03	-5.16E-02
Alopecia	ED70	Skin from scalp	1.42E-01	4.57E-02	1.78E-01
Alzheimer's disease	8A20	Entorhinal cortex	7.43E-01	-2.59E-02	-1.09E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	3.70E-01	8.40E-02	7.93E-01
Aortic stenosis	BB70	Calcified aortic valve	4.84E-01	1.58E-01	3.54E-01
Apnea	7A40	Hyperplastic tonsil	1.50E-01	-1.21E-01	-8.60E-01
Arthropathy	FA00-FA5Z	Peripheral blood	3.97E-01	2.48E-02	1.39E-01
Asthma	CA23	Nasal and bronchial airway	3.23E-03	-1.52E-01	-4.42E-01
Atopic dermatitis	EA80	Skin	9.91E-02	2.40E-03	3.44E-02
Autism	6A02	Whole blood	4.06E-02	-1.25E-01	-5.35E-01
Autoimmune uveitis	9A96	Peripheral monocyte	6.65E-02	-1.62E-01	-8.24E-01
Autosomal dominant monocytopenia	4B04	Whole blood	6.23E-01	-1.34E-01	-6.16E-01
Bacterial infection of gingival	1C1H	Gingival tissue	3.39E-01	2.03E-02	8.06E-02
Batten disease	5C56.1	Whole blood	9.62E-01	-2.54E-02	-2.81E-01
Behcet's disease	4A62	Peripheral blood	4.96E-01	-1.31E-02	-1.39E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	7.62E-01	2.45E-03	1.58E-02
Bladder cancer	2C94	Bladder tissue	3.74E-03	2.47E-01	1.95E+00
Breast cancer	2C60-2C6Z	Breast tissue	5.55E-02	7.33E-03	2.49E-02
Cardioembolic stroke	8B11.20	Whole blood	3.06E-02	-1.41E-01	-4.96E-01
Cervical cancer	2C77	Cervical tissue	7.82E-01	2.87E-02	1.38E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	6.82E-02	7.09E-02	3.31E-01
Chronic hepatitis C	1E51.1	Whole blood	9.63E-01	-5.99E-02	-3.89E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	5.92E-02	8.78E-02	4.52E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	4.82E-01	-1.61E-02	-7.26E-02
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	8.12E-02	1.30E-01	1.23E+00
Colon cancer	2B90	Colon tissue	5.80E-07	-8.09E-02	-3.70E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	5.72E-01	-5.10E-02	-1.29E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	5.99E-02	-1.21E-01	-8.53E-01
Endometriosis	GA10	Endometrium tissue	7.31E-01	-7.01E-03	-3.63E-02
Familial hypercholesterolemia	5C80.00	Peripheral blood	4.93E-01	-3.15E-03	-1.39E-02
Familial hypercholesterolemia	5C80.00	Whole blood	1.71E-03	-3.67E-01	-1.36E+00
Gastric cancer	2B72	Gastric tissue	3.66E-01	-3.78E-02	-1.61E-01
Glioblastopma	2A00.00	Nervous tissue	1.37E-11	-1.48E-01	-4.37E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	2.14E-01	1.28E-01	6.53E-01
Head and neck cancer	2D42	Head and neck tissue	1.64E-08	-1.35E-01	-5.90E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	3.40E-01	-4.20E-02	-1.51E-01
Huntington's disease	8A01.10	Whole blood	4.78E-01	1.40E-02	8.26E-02
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	9.75E-02	2.97E-01	1.49E+00
Immunodeficiency	4A00-4A20	Peripheral blood	3.82E-02	-1.23E-01	-1.33E+00
Influenza	1.00E+30	Whole blood	2.74E-04	4.36E-01	5.50E+00
Interstitial cystitis	GC00.3	Bladder tissue	3.69E-01	9.43E-02	3.82E-01
Intracranial aneurysm	8B01.0	Intracranial artery	2.59E-02	-2.66E-02	-1.81E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	2.85E-01	-3.75E-02	-1.86E-01
Ischemic stroke	8B11	Peripheral blood	3.70E-01	-5.27E-02	-3.38E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	7.03E-01	-1.36E-02	-5.28E-02
Lateral sclerosis	8B60.4	Cervical spinal cord	4.81E-01	9.08E-02	3.93E-01
Lateral sclerosis	8B60.4	Skin	6.20E-01	6.09E-02	1.89E+00
Liver cancer	2C12.0	Liver tissue	1.73E-07	-2.16E-01	-1.03E+00
Liver failure	DB99.7-DB99.8	Liver tissue	2.66E-01	1.75E-02	1.11E-01
Lung cancer	2C25	Lung tissue	8.49E-02	-5.07E-02	-2.54E-01
Lupus erythematosus	4A40	Whole blood	4.77E-04	-6.90E-02	-3.02E-01
Major depressive disorder	6A70-6A7Z	Whole blood	3.02E-02	4.65E-02	2.11E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	7.33E-01	1.18E-02	7.48E-02
Melanoma	2C30	Skin	8.84E-01	4.58E-02	1.39E-01
Multiple myeloma	2A83.1	Bone marrow	4.44E-02	1.90E-01	4.54E-01
Multiple myeloma	2A83.1	Peripheral blood	5.83E-01	3.24E-03	2.80E-02
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	7.08E-02	1.98E-01	5.68E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	2.63E-01	-7.69E-02	-4.58E-01
Myelofibrosis	2A20.2	Whole blood	3.15E-01	-1.93E-02	-1.48E-01
Myocardial infarction	BA41-BA50	Peripheral blood	6.19E-01	-1.84E-02	-4.78E-02
Myopathy	8C70.6	Muscle tissue	3.49E-01	-1.38E-01	-5.41E-01
Neonatal sepsis	KA60	Whole blood	6.60E-01	-3.92E-02	-1.42E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	4.97E-03	-3.01E-01	-1.17E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	4.52E-02	1.22E-01	1.00E+00
Obesity related type 2 diabetes	5A11	Omental adipose tissue	9.72E-01	-3.53E-03	-2.08E-02
Olive pollen allergy	CA08.00	Peripheral blood	6.82E-02	9.50E-02	1.64E+00
Oral cancer	2B6E	Oral tissue	4.12E-02	-9.38E-02	-3.90E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	3.87E-01	8.50E-02	6.03E-01
Osteoporosis	FB83.1	Bone marrow	3.03E-02	3.71E-01	1.96E+00
Ovarian cancer	2C73	Ovarian tissue	8.63E-01	-6.11E-02	-5.24E-01
Pancreatic cancer	2C10	Pancreas	1.05E-03	-2.62E-01	-6.52E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	8.77E-02	-7.60E-02	-4.17E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	8.90E-03	5.07E-02	7.58E-01
Pituitary cancer	2D12	Pituitary tissue	6.22E-01	-1.29E-02	-7.35E-02
Pituitary gonadotrope tumour	2D12	Pituitary tissue	4.65E-01	2.74E-02	9.69E-02
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	8.25E-02	3.89E-02	2.52E-01
Polycythemia vera	2A20.4	Whole blood	9.23E-01	1.52E-02	1.10E-01
Pompe disease	5C51.3	Biceps muscle	3.20E-01	-9.10E-02	-7.60E-01
Preterm birth	KA21.4Z	Myometrium	3.46E-01	-5.76E-02	-3.36E-01
Prostate cancer	2C82	Prostate	2.25E-02	-4.82E-01	-9.58E-01
Psoriasis	EA90	Skin	8.33E-07	-1.74E-01	-6.63E-01
Rectal cancer	2B92	Rectal colon tissue	1.20E-01	-1.54E-01	-7.32E-01
Renal cancer	2C90-2C91	Kidney	3.37E-01	-9.16E-02	-6.03E-01
Retinoblastoma	2D02.2	Uvea	1.86E-10	-9.38E-01	-3.57E+00
Rheumatoid arthritis	FA20	Synovial tissue	8.12E-01	5.59E-02	2.56E-01
Rhinovirus infection	CA42.1	Nasal epithelium tissue	4.40E-02	-7.38E-02	-5.36E-01
Schizophrenia	6A20	Prefrontal cortex	8.23E-01	-9.26E-03	-4.08E-02
Schizophrenia	6A20	Superior temporal cortex	6.99E-01	-1.26E-02	-1.24E-01
Scleroderma	4A42.Z	Whole blood	6.23E-02	1.47E-01	1.28E+00
Seizure	8A60-8A6Z	Whole blood	2.99E-01	1.96E-02	8.16E-02
Sensitive skin	EK0Z	Skin	8.58E-01	9.77E-03	8.90E-02
Sepsis with septic shock	1G41	Whole blood	3.96E-01	-1.64E-02	-5.34E-02
Shwachman-Diamond syndrome	3A70.0	Bone marrow	6.84E-01	1.36E-01	8.00E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	2.26E-01	1.78E-01	5.56E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	1.14E-01	6.90E-02	3.02E+00
Sjogren's syndrome	4A43.2	Salivary gland tissue	7.09E-01	-1.01E-01	-6.17E-01
Skin cancer	2C30-2C3Z	Skin	3.78E-11	-1.38E-01	-5.48E-01
Thrombocythemia	3B63	Whole blood	6.84E-01	7.37E-03	6.08E-02
Thrombocytopenia	3B64	Whole blood	9.32E-02	1.62E-01	8.01E-01
Thyroid cancer	2D10	Thyroid	6.49E-07	-5.90E-01	-8.57E-01
Tibial muscular dystrophy	8C75	Muscle tissue	8.99E-01	-6.85E-02	-3.88E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	1.61E-01	2.77E-01	1.81E+00
Type 2 diabetes	5A11	Liver tissue	3.59E-01	-1.75E-01	-8.24E-01
Ureter cancer	2C92	Urothelium	9.43E-01	5.66E-02	2.59E-01
Uterine cancer	2C78	Endometrium tissue	4.40E-07	-1.47E-01	-6.33E-01
Vitiligo	ED63.0	Skin	2.81E-03	9.16E-02	1.02E+00