Details of the Drug-Related molecule(s) Expression Atlas

General Information of DTP (ID: DTHKL3Q)

• DTP Name: Basolateral Na-K-Cl symporter (SLC12A2) DTP Info
• Gene Name: NKCC1

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	8.05E-15	4.35E-01	1.18E+00
Adrenocortical carcinoma	2D11.Z	Kidney	1.57E-01	-5.43E-01	-7.01E-01
Alopecia	ED70	Skin from scalp	2.77E-01	5.04E-02	1.07E-01
Alzheimer's disease	8A20	Entorhinal cortex	7.72E-01	4.29E-04	7.46E-04
Ankylosing spondylitis	FA92.0	Pheripheral blood	7.44E-01	-7.64E-02	-5.69E-01
Aortic stenosis	BB70	Calcified aortic valve	7.17E-01	-2.91E-02	-4.36E-02
Apnea	7A40	Hyperplastic tonsil	9.43E-01	1.41E-01	4.28E-01
Arthropathy	FA00-FA5Z	Peripheral blood	1.07E-01	-1.02E-01	-4.29E-01
Asthma	CA23	Nasal and bronchial airway	2.63E-03	1.93E-01	3.57E-01
Atopic dermatitis	EA80	Skin	5.78E-02	6.08E-02	1.29E-01
Autism	6A02	Whole blood	3.17E-01	6.55E-02	2.58E-01
Autoimmune uveitis	9A96	Peripheral monocyte	7.92E-01	6.19E-02	2.78E-01
Autosomal dominant monocytopenia	4B04	Whole blood	1.22E-01	2.70E-01	8.15E-01
Bacterial infection of gingival	1C1H	Gingival tissue	9.81E-04	-1.17E-01	-3.60E-01
Batten disease	5C56.1	Whole blood	9.20E-01	-1.17E-01	-4.63E-01
Behcet's disease	4A62	Peripheral blood	7.35E-01	5.30E-02	2.12E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	6.56E-01	-4.29E-02	-1.47E-01
Bladder cancer	2C94	Bladder tissue	9.76E-01	6.84E-02	2.95E-01
Breast cancer	2C60-2C6Z	Breast tissue	3.66E-01	-2.27E-01	-2.51E-01
Cardioembolic stroke	8B11.20	Whole blood	7.73E-01	1.77E-01	4.30E-01
Cervical cancer	2C77	Cervical tissue	6.04E-01	-1.50E-01	-3.51E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	8.11E-01	-1.43E-01	-2.08E-01
Chronic hepatitis C	1E51.1	Whole blood	5.77E-01	-1.23E-02	-2.53E-02
Chronic obstructive pulmonary disease	CA22	Lung tissue	3.69E-02	-2.60E-01	-7.18E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	6.28E-03	-1.22E-01	-2.75E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	1.88E-02	5.21E-01	6.35E-01
Colon cancer	2B90	Colon tissue	8.16E-84	1.21E+00	2.84E+00
Coronary artery disease	BA80-BA8Z	Peripheral blood	1.13E-01	1.59E-01	7.32E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	2.34E-01	2.26E-01	2.57E-01
Endometriosis	GA10	Endometrium tissue	3.76E-02	-4.12E-01	-9.67E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	9.25E-01	4.38E-02	1.60E-01
Familial hypercholesterolemia	5C80.00	Whole blood	6.36E-01	8.71E-02	4.41E-01
Gastric cancer	2B72	Gastric tissue	5.73E-01	3.50E-01	2.78E-01
Glioblastopma	2A00.00	Nervous tissue	2.73E-12	-2.38E-01	-3.54E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	3.50E-04	-7.67E-01	-2.61E+00
Head and neck cancer	2D42	Head and neck tissue	1.26E-05	-9.40E-01	-7.65E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	2.94E-01	2.50E-01	3.01E-01
Huntington's disease	8A01.10	Whole blood	7.20E-02	-1.45E-01	-8.83E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	7.67E-01	1.20E-01	3.43E-01
Immunodeficiency	4A00-4A20	Peripheral blood	3.56E-01	8.05E-04	5.99E-03
Influenza	1.00E+30	Whole blood	3.70E-01	-1.74E-01	-1.73E+00
Interstitial cystitis	GC00.3	Bladder tissue	7.85E-01	-5.66E-03	-2.54E-02
Intracranial aneurysm	8B01.0	Intracranial artery	2.81E-01	3.57E-01	5.22E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	2.07E-01	5.65E-02	2.60E-01
Ischemic stroke	8B11	Peripheral blood	5.02E-01	2.67E-02	9.54E-02
Juvenile idiopathic arthritis	FA24	Peripheral blood	1.17E-01	-1.25E-01	-2.46E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	1.71E-01	-2.50E-01	-6.66E-01
Lateral sclerosis	8B60.4	Skin	4.15E-01	7.71E-02	1.81E-01
Liver cancer	2C12.0	Liver tissue	6.49E-09	3.17E-01	6.81E-01
Liver failure	DB99.7-DB99.8	Liver tissue	2.11E-05	1.88E+00	3.36E+00
Lung cancer	2C25	Lung tissue	5.51E-04	8.84E-02	2.21E-01
Lupus erythematosus	4A40	Whole blood	1.01E-01	-4.51E-02	-8.88E-02
Major depressive disorder	6A70-6A7Z	Whole blood	6.45E-01	-1.88E-02	-5.18E-02
Major depressive disorder	6A70-6A7Z	Hippocampus	9.70E-01	-6.56E-02	-2.18E-01
Melanoma	2C30	Skin	1.02E-03	-1.63E+00	-1.27E+00
Multiple myeloma	2A83.1	Bone marrow	2.54E-07	9.85E-01	4.83E+00
Multiple myeloma	2A83.1	Peripheral blood	2.67E-01	-1.41E-01	-4.44E-01
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	8.16E-01	1.13E-01	5.31E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	2.19E-09	-4.06E-01	-1.49E+00
Myelofibrosis	2A20.2	Whole blood	3.26E-01	1.16E-01	4.77E-01
Myocardial infarction	BA41-BA50	Peripheral blood	4.92E-01	-2.01E-01	-2.84E-01
Myopathy	8C70.6	Muscle tissue	8.20E-01	1.67E-02	1.18E-01
Neonatal sepsis	KA60	Whole blood	3.32E-08	-5.21E-01	-1.13E+00
Neuroectodermal tumour	2A00.11	Brain stem tissue	1.70E-04	-1.13E+00	-2.27E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	2.63E-01	8.98E-02	2.27E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	3.09E-01	-2.57E-01	-6.74E-01
Olive pollen allergy	CA08.00	Peripheral blood	9.14E-01	1.56E-01	6.36E-01
Oral cancer	2B6E	Oral tissue	4.44E-01	6.68E-01	4.05E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	5.88E-01	9.26E-02	1.65E-01
Osteoporosis	FB83.1	Bone marrow	5.13E-02	-3.04E-01	-8.12E-01
Ovarian cancer	2C73	Ovarian tissue	7.24E-04	7.45E-01	1.60E+00
Pancreatic cancer	2C10	Pancreas	6.30E-04	1.64E+00	1.51E+00
Parkinson's disease	8A00.0	Substantia nigra tissue	9.87E-01	-3.01E-02	-7.47E-02
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	3.84E-02	-1.98E-01	-1.03E+00
Pituitary cancer	2D12	Pituitary tissue	7.95E-02	-4.04E-01	-8.82E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	8.35E-03	-5.57E-01	-1.29E+00
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	4.94E-01	-7.12E-02	-1.87E-01
Polycythemia vera	2A20.4	Whole blood	4.46E-02	-1.27E-01	-4.66E-01
Pompe disease	5C51.3	Biceps muscle	6.84E-02	-5.34E-01	-1.63E+00
Preterm birth	KA21.4Z	Myometrium	3.18E-01	1.04E-01	8.96E-01
Prostate cancer	2C82	Prostate	1.04E-01	3.16E-01	3.82E-01
Psoriasis	EA90	Skin	1.22E-20	-9.65E-01	-1.50E+00
Rectal cancer	2B92	Rectal colon tissue	7.70E-05	1.15E+00	3.69E+00
Renal cancer	2C90-2C91	Kidney	1.55E-02	6.64E-01	9.76E-01
Retinoblastoma	2D02.2	Uvea	2.23E-06	-1.05E+00	-4.82E+00
Rheumatoid arthritis	FA20	Synovial tissue	1.97E-01	-2.06E-01	-3.06E-01
Rhinovirus infection	CA42.1	Nasal epithelium tissue	6.58E-01	1.09E-01	3.42E-01
Schizophrenia	6A20	Prefrontal cortex	2.18E-02	-1.75E-01	-2.45E-01
Schizophrenia	6A20	Superior temporal cortex	4.55E-03	-2.63E-01	-8.25E-01
Scleroderma	4A42.Z	Whole blood	6.57E-06	-2.99E-01	-2.74E+00
Seizure	8A60-8A6Z	Whole blood	6.22E-01	1.70E-02	3.35E-02
Sensitive skin	EK0Z	Skin	1.65E-02	-6.29E-01	-1.12E+00
Sepsis with septic shock	1G41	Whole blood	1.95E-25	-5.31E-01	-1.46E+00
Shwachman-Diamond syndrome	3A70.0	Bone marrow	1.79E-01	-3.38E-01	-1.16E+00
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	2.91E-03	-2.59E-01	-1.03E+00
Simpson golabi behmel syndrome	LD2C	Adipose tissue	9.90E-01	-1.07E-01	-2.28E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	9.51E-01	1.20E-01	2.63E-01
Skin cancer	2C30-2C3Z	Skin	6.27E-79	-1.92E+00	-2.12E+00
Thrombocythemia	3B63	Whole blood	7.96E-01	7.56E-02	2.94E-01
Thrombocytopenia	3B64	Whole blood	2.95E-01	-1.36E-01	-1.59E-01
Thyroid cancer	2D10	Thyroid	1.64E-42	7.03E-01	2.39E+00
Tibial muscular dystrophy	8C75	Muscle tissue	5.19E-05	5.71E-01	1.51E+00
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	9.23E-01	-6.29E-02	-2.09E-01
Type 2 diabetes	5A11	Liver tissue	7.54E-02	1.68E-01	9.71E-01
Ureter cancer	2C92	Urothelium	2.50E-01	-2.16E-02	-1.85E-01
Uterine cancer	2C78	Endometrium tissue	1.05E-03	9.95E-02	1.42E-01
Vitiligo	ED63.0	Skin	9.32E-01	2.97E-01	2.93E-01