Details of the Drug-Related molecule(s) Expression Atlas

General Information of DTP (ID: DTMA4FJ)

• DTP Name: Electroneutral potassium-chloride cotransporter 3 (SLC12A6) DTP Info
• Gene Name: KCC3

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	9.62E-08	-3.59E-01	-4.49E-01
Adrenocortical carcinoma	2D11.Z	Kidney	9.13E-01	7.98E-04	2.21E-03
Alopecia	ED70	Skin from scalp	8.35E-03	7.13E-02	2.07E-01
Alzheimer's disease	8A20	Entorhinal cortex	6.72E-09	-2.72E-01	-7.01E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	8.43E-03	4.35E-01	1.28E+00
Aortic stenosis	BB70	Calcified aortic valve	3.58E-01	2.90E-01	6.84E-01
Apnea	7A40	Hyperplastic tonsil	7.75E-01	8.07E-01	1.52E+00
Arthropathy	FA00-FA5Z	Peripheral blood	6.62E-02	2.35E-01	7.04E-01
Asthma	CA23	Nasal and bronchial airway	2.44E-02	-2.49E-01	-1.79E-01
Atopic dermatitis	EA80	Skin	1.53E-02	9.79E-02	6.67E-01
Autism	6A02	Whole blood	2.25E-01	5.45E-02	1.31E-01
Autoimmune uveitis	9A96	Peripheral monocyte	3.64E-02	8.99E-01	1.69E+00
Autosomal dominant monocytopenia	4B04	Whole blood	7.29E-01	1.12E+00	1.72E+00
Bacterial infection of gingival	1C1H	Gingival tissue	2.98E-01	-7.51E-03	-1.94E-02
Batten disease	5C56.1	Whole blood	6.41E-01	-6.09E-02	-2.62E-01
Behcet's disease	4A62	Peripheral blood	8.04E-01	7.81E-02	3.81E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	3.66E-01	-8.11E-02	-5.09E-01
Bladder cancer	2C94	Bladder tissue	6.34E-01	-3.47E-01	-9.80E-01
Breast cancer	2C60-2C6Z	Breast tissue	2.32E-16	-2.39E-01	-6.89E-01
Cardioembolic stroke	8B11.20	Whole blood	7.97E-13	8.14E-01	2.73E+00
Cervical cancer	2C77	Cervical tissue	5.19E-02	-5.92E-01	-5.94E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	8.18E-01	2.20E-01	1.56E-01
Chronic hepatitis C	1E51.1	Whole blood	1.28E-01	3.30E-01	1.24E+00
Chronic obstructive pulmonary disease	CA22	Lung tissue	4.82E-02	-6.84E-03	-2.22E-02
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	6.51E-02	-8.37E-02	-2.00E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	4.53E-02	7.43E-02	2.56E-01
Colon cancer	2B90	Colon tissue	3.34E-11	-2.29E-01	-6.47E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	2.52E-01	9.17E-01	8.77E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	8.62E-01	-6.64E-02	-7.26E-02
Endometriosis	GA10	Endometrium tissue	1.99E-01	-4.93E-02	-1.02E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	4.75E-01	9.40E-02	3.30E-01
Familial hypercholesterolemia	5C80.00	Whole blood	1.48E-03	-4.48E-01	-1.08E+00
Gastric cancer	2B72	Gastric tissue	6.12E-01	-3.04E-02	-8.93E-02
Glioblastopma	2A00.00	Nervous tissue	5.52E-62	-5.87E-01	-1.07E+00
Glioma	2A00.0Y-2A00.0Z	White matter tissue	4.41E-01	-4.04E-02	-2.76E-02
Head and neck cancer	2D42	Head and neck tissue	4.75E-04	-2.65E-01	-4.07E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	6.03E-02	-8.72E-02	-1.97E-01
Huntington's disease	8A01.10	Whole blood	7.90E-01	-7.32E-02	-6.03E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	1.76E-02	-3.05E-01	-1.07E+00
Immunodeficiency	4A00-4A20	Peripheral blood	6.90E-01	4.76E-02	2.78E-01
Influenza	1.00E+30	Whole blood	1.62E-01	-5.37E-01	-1.06E+00
Interstitial cystitis	GC00.3	Bladder tissue	4.30E-01	-5.21E-02	-2.85E-01
Intracranial aneurysm	8B01.0	Intracranial artery	4.08E-03	7.61E-01	2.24E+00
Irritable bowel syndrome	DD91.0	Rectal colon tissue	6.79E-01	-2.99E-02	-7.83E-02
Ischemic stroke	8B11	Peripheral blood	5.75E-01	1.03E-01	4.62E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	1.23E-03	1.80E-01	2.83E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	9.25E-01	3.84E-01	4.97E-01
Lateral sclerosis	8B60.4	Skin	9.50E-01	-9.84E-02	-3.63E-01
Liver cancer	2C12.0	Liver tissue	1.84E-01	-9.89E-02	-2.84E-01
Liver failure	DB99.7-DB99.8	Liver tissue	3.66E-04	5.88E-01	2.11E+00
Lung cancer	2C25	Lung tissue	1.54E-01	-8.57E-02	-2.63E-01
Lupus erythematosus	4A40	Whole blood	2.61E-05	3.70E-01	5.37E-01
Major depressive disorder	6A70-6A7Z	Whole blood	5.44E-03	1.61E-01	4.36E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	6.87E-01	-6.95E-02	-4.23E-01
Melanoma	2C30	Skin	8.10E-01	4.77E-02	5.68E-02
Multiple myeloma	2A83.1	Bone marrow	1.24E-01	4.07E-02	1.06E-01
Multiple myeloma	2A83.1	Peripheral blood	4.01E-01	1.33E-01	4.00E-01
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	8.01E-02	-4.30E-01	-1.18E+00
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	2.91E-01	3.27E-01	4.87E-01
Myelofibrosis	2A20.2	Whole blood	5.77E-01	-3.24E-02	-1.02E-01
Myocardial infarction	BA41-BA50	Peripheral blood	3.47E-04	5.20E-01	6.28E-01
Myopathy	8C70.6	Muscle tissue	1.41E-01	1.15E-01	3.86E-01
Neonatal sepsis	KA60	Whole blood	1.69E-16	6.46E-01	1.53E+00
Neuroectodermal tumour	2A00.11	Brain stem tissue	2.26E-06	-5.66E-01	-2.86E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	4.73E-01	-2.73E-02	-2.15E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	5.35E-02	7.24E-02	7.08E-01
Olive pollen allergy	CA08.00	Peripheral blood	2.53E-01	-7.79E-01	-7.63E-01
Oral cancer	2B6E	Oral tissue	5.97E-02	1.36E-01	2.81E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	5.63E-02	3.01E-01	7.15E-01
Osteoporosis	FB83.1	Bone marrow	6.25E-02	4.56E-01	1.28E+00
Ovarian cancer	2C73	Ovarian tissue	1.08E-04	3.86E-01	2.22E+00
Pancreatic cancer	2C10	Pancreas	1.29E-02	3.29E-01	6.96E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	4.85E-01	-2.99E-02	-1.62E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	1.24E-02	3.33E-01	1.34E+00
Pituitary cancer	2D12	Pituitary tissue	9.64E-02	-1.20E-01	-4.00E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	3.48E-02	-2.41E-01	-7.18E-01
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	1.66E-01	-1.66E-01	-5.58E-01
Polycythemia vera	2A20.4	Whole blood	1.69E-02	2.01E-01	6.06E-01
Pompe disease	5C51.3	Biceps muscle	5.63E-01	4.01E-03	1.66E-02
Preterm birth	KA21.4Z	Myometrium	3.32E-01	-2.18E-02	-4.53E-02
Prostate cancer	2C82	Prostate	3.04E-03	4.53E-01	7.75E-01
Psoriasis	EA90	Skin	3.72E-06	1.69E-01	3.37E-01
Rectal cancer	2B92	Rectal colon tissue	9.11E-01	-1.81E-02	-5.36E-02
Renal cancer	2C90-2C91	Kidney	1.53E-01	-3.15E-01	-4.27E-01
Retinoblastoma	2D02.2	Uvea	5.93E-10	-1.50E+00	-3.61E+00
Rheumatoid arthritis	FA20	Synovial tissue	2.58E-02	4.57E-01	1.31E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	4.53E-01	1.37E-02	4.36E-02
Schizophrenia	6A20	Prefrontal cortex	5.83E-01	3.91E-02	7.65E-02
Schizophrenia	6A20	Superior temporal cortex	8.99E-01	-5.84E-03	-4.34E-02
Scleroderma	4A42.Z	Whole blood	4.31E-04	7.13E-01	1.65E+00
Seizure	8A60-8A6Z	Whole blood	4.56E-01	-2.75E-01	-6.56E-01
Sensitive skin	EK0Z	Skin	5.37E-01	2.96E-03	2.86E-02
Sepsis with septic shock	1G41	Whole blood	2.36E-36	8.07E-01	1.81E+00
Shwachman-Diamond syndrome	3A70.0	Bone marrow	7.90E-01	-2.73E-01	-5.34E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	3.13E-01	1.55E-01	4.07E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	3.28E-01	4.14E-01	1.51E+00
Sjogren's syndrome	4A43.2	Salivary gland tissue	1.09E-02	3.85E-01	2.71E+00
Skin cancer	2C30-2C3Z	Skin	4.11E-02	-7.15E-02	-1.96E-01
Thrombocythemia	3B63	Whole blood	9.17E-01	-7.10E-02	-2.24E-01
Thrombocytopenia	3B64	Whole blood	1.79E-01	-7.47E-01	-8.47E-01
Thyroid cancer	2D10	Thyroid	8.07E-02	-2.19E-01	-6.14E-01
Tibial muscular dystrophy	8C75	Muscle tissue	6.24E-01	-1.98E-02	-8.83E-02
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	3.75E-01	-2.39E-01	-9.07E-01
Type 2 diabetes	5A11	Liver tissue	2.13E-01	-1.82E-01	-1.12E+00
Ureter cancer	2C92	Urothelium	7.13E-02	-7.65E-02	-1.93E-01
Uterine cancer	2C78	Endometrium tissue	1.10E-04	4.73E-01	4.94E-01
Vitiligo	ED63.0	Skin	9.22E-01	-5.63E-04	-4.76E-03