Details of the Drug-Related molecule(s) Expression Atlas

General Information of DTP (ID: DTY25IU)

• DTP Name: Electroneutral potassium-chloride cotransporter 1 (SLC12A4) DTP Info
• Gene Name: KCC1

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	3.46E-02	4.32E-02	1.57E-01
Adrenocortical carcinoma	2D11.Z	Kidney	1.33E-01	-5.92E-02	-2.90E-01
Alopecia	ED70	Skin from scalp	7.68E-03	-1.61E-01	-7.19E-01
Alzheimer's disease	8A20	Entorhinal cortex	4.92E-01	7.06E-03	4.55E-02
Ankylosing spondylitis	FA92.0	Pheripheral blood	6.13E-01	2.80E-03	1.73E-02
Aortic stenosis	BB70	Calcified aortic valve	5.74E-01	1.61E-01	2.63E-01
Apnea	7A40	Hyperplastic tonsil	3.02E-01	-3.97E-01	-1.38E+00
Arthropathy	FA00-FA5Z	Peripheral blood	9.58E-02	1.36E-01	9.77E-01
Asthma	CA23	Nasal and bronchial airway	3.39E-04	-1.87E-01	-6.70E-01
Atopic dermatitis	EA80	Skin	1.78E-02	-7.92E-02	-4.62E-01
Autism	6A02	Whole blood	9.48E-01	1.22E-02	4.73E-02
Autoimmune uveitis	9A96	Peripheral monocyte	6.88E-05	-3.00E-01	-2.97E+00
Autosomal dominant monocytopenia	4B04	Whole blood	4.21E-01	-3.89E-02	-3.47E-01
Bacterial infection of gingival	1C1H	Gingival tissue	7.97E-01	2.40E-02	9.29E-02
Batten disease	5C56.1	Whole blood	8.85E-01	4.74E-02	4.55E-01
Behcet's disease	4A62	Peripheral blood	6.94E-02	7.35E-02	5.06E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	8.21E-01	-6.17E-03	-3.35E-02
Bladder cancer	2C94	Bladder tissue	4.45E-04	5.41E-01	2.42E+00
Breast cancer	2C60-2C6Z	Breast tissue	4.97E-08	-8.57E-02	-4.26E-01
Cardioembolic stroke	8B11.20	Whole blood	1.22E-02	1.50E-01	9.82E-01
Cervical cancer	2C77	Cervical tissue	2.06E-02	1.03E-01	8.56E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	8.53E-01	-1.04E-01	-3.76E-01
Chronic hepatitis C	1E51.1	Whole blood	5.98E-01	2.53E-03	1.91E-02
Chronic obstructive pulmonary disease	CA22	Lung tissue	9.96E-02	1.29E-01	5.22E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	4.74E-01	-1.98E-03	-7.74E-03
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	3.25E-01	2.55E-02	2.01E-01
Colon cancer	2B90	Colon tissue	1.94E-07	-8.54E-02	-4.38E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	1.42E-01	-2.07E-01	-7.14E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	5.19E-01	6.92E-03	3.64E-02
Endometriosis	GA10	Endometrium tissue	8.86E-01	-3.00E-02	-1.14E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	7.87E-01	-3.64E-02	-1.56E-01
Familial hypercholesterolemia	5C80.00	Whole blood	9.16E-01	-3.42E-03	-1.86E-02
Gastric cancer	2B72	Gastric tissue	1.85E-01	1.43E-01	9.01E-01
Glioblastopma	2A00.00	Nervous tissue	1.23E-02	-2.09E-02	-8.97E-02
Glioma	2A00.0Y-2A00.0Z	White matter tissue	7.08E-05	-6.91E-01	-2.65E+00
Head and neck cancer	2D42	Head and neck tissue	7.52E-01	-1.53E-02	-7.19E-02
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	5.51E-01	-2.82E-02	-1.97E-01
Huntington's disease	8A01.10	Whole blood	9.45E-01	5.12E-02	2.40E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	8.96E-01	-7.37E-02	-6.39E-01
Immunodeficiency	4A00-4A20	Peripheral blood	1.06E-02	9.38E-02	1.32E+00
Influenza	1.00E+30	Whole blood	4.06E-02	4.13E-01	3.00E+00
Interstitial cystitis	GC00.3	Bladder tissue	3.28E-01	-9.60E-02	-4.76E-01
Intracranial aneurysm	8B01.0	Intracranial artery	5.40E-01	-1.10E-01	-4.27E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	8.37E-01	1.44E-02	6.44E-02
Ischemic stroke	8B11	Peripheral blood	9.81E-01	-5.03E-02	-3.53E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	2.15E-01	6.94E-02	1.86E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	3.12E-01	-2.16E-01	-7.25E-01
Lateral sclerosis	8B60.4	Skin	3.65E-01	1.78E-01	8.50E-01
Liver cancer	2C12.0	Liver tissue	1.35E-02	-1.09E-01	-3.28E-01
Liver failure	DB99.7-DB99.8	Liver tissue	5.50E-01	3.16E-03	1.48E-02
Lung cancer	2C25	Lung tissue	1.93E-06	-1.09E-01	-4.58E-01
Lupus erythematosus	4A40	Whole blood	1.15E-03	-2.37E-01	-4.79E-01
Major depressive disorder	6A70-6A7Z	Whole blood	3.08E-01	3.38E-02	1.57E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	2.01E-01	4.24E-02	2.58E-01
Melanoma	2C30	Skin	7.05E-01	6.59E-02	1.09E-01
Multiple myeloma	2A83.1	Bone marrow	2.15E-01	-1.67E-01	-5.53E-01
Multiple myeloma	2A83.1	Peripheral blood	9.84E-01	-5.03E-02	-2.69E-01
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	8.21E-01	1.82E-01	7.81E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	4.89E-01	1.79E-03	8.60E-03
Myelofibrosis	2A20.2	Whole blood	7.15E-01	3.42E-02	2.38E-01
Myocardial infarction	BA41-BA50	Peripheral blood	9.82E-02	2.54E-01	5.04E-01
Myopathy	8C70.6	Muscle tissue	4.94E-03	-1.78E-01	-1.19E+00
Neonatal sepsis	KA60	Whole blood	1.62E-01	-1.73E-02	-6.40E-02
Neuroectodermal tumour	2A00.11	Brain stem tissue	7.39E-01	6.82E-02	2.33E-01
Non-alcoholic fatty liver disease	DB92	Liver tissue	6.58E-02	-4.65E-01	-1.65E+00
Obesity related type 2 diabetes	5A11	Omental adipose tissue	3.07E-01	1.26E-01	5.96E-01
Olive pollen allergy	CA08.00	Peripheral blood	5.55E-01	1.08E-01	4.90E-01
Oral cancer	2B6E	Oral tissue	4.13E-08	-4.51E-01	-1.63E+00
Osteoarthritis	FA00-FA0Z	Synovial tissue	1.18E-01	-1.62E-01	-7.01E-01
Osteoporosis	FB83.1	Bone marrow	3.61E-01	1.21E-01	6.97E-01
Ovarian cancer	2C73	Ovarian tissue	6.54E-01	-8.41E-02	-3.16E-01
Pancreatic cancer	2C10	Pancreas	3.83E-01	-1.06E-01	-3.74E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	4.55E-01	-1.53E-01	-6.59E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	8.97E-01	-3.37E-02	-2.51E-01
Pituitary cancer	2D12	Pituitary tissue	7.00E-02	1.69E-01	6.96E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	5.16E-01	1.24E-01	3.77E-01
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	2.37E-01	4.84E-02	3.08E-01
Polycythemia vera	2A20.4	Whole blood	9.04E-01	2.25E-02	1.44E-01
Pompe disease	5C51.3	Biceps muscle	1.16E-02	2.46E-01	1.64E+00
Preterm birth	KA21.4Z	Myometrium	2.53E-01	1.13E-01	7.95E-01
Prostate cancer	2C82	Prostate	7.80E-01	-4.85E-02	-1.37E-01
Psoriasis	EA90	Skin	2.10E-01	-1.21E-02	-3.67E-02
Rectal cancer	2B92	Rectal colon tissue	5.10E-01	-5.27E-02	-2.23E-01
Renal cancer	2C90-2C91	Kidney	1.04E-01	-1.19E-01	-6.95E-01
Retinoblastoma	2D02.2	Uvea	2.32E-04	-3.19E-01	-2.04E+00
Rheumatoid arthritis	FA20	Synovial tissue	2.58E-02	-3.81E-01	-1.70E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	6.56E-01	1.39E-02	9.84E-02
Schizophrenia	6A20	Prefrontal cortex	4.54E-01	-4.53E-03	-1.91E-02
Schizophrenia	6A20	Superior temporal cortex	2.82E-01	7.47E-04	4.87E-03
Scleroderma	4A42.Z	Whole blood	3.66E-01	6.39E-02	3.55E-01
Seizure	8A60-8A6Z	Whole blood	6.47E-01	3.31E-02	1.45E-01
Sensitive skin	EK0Z	Skin	3.69E-01	1.05E-01	3.30E-01
Sepsis with septic shock	1G41	Whole blood	5.12E-01	2.26E-03	8.39E-03
Shwachman-Diamond syndrome	3A70.0	Bone marrow	9.49E-02	2.77E-02	1.43E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	6.30E-01	-3.18E-02	-1.22E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	4.12E-01	-2.72E-02	-4.62E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	1.12E-01	-4.90E-01	-1.37E+00
Skin cancer	2C30-2C3Z	Skin	1.26E-03	-1.58E-01	-4.14E-01
Thrombocythemia	3B63	Whole blood	5.58E-01	-1.37E-02	-8.69E-02
Thrombocytopenia	3B64	Whole blood	7.29E-01	1.32E-01	2.93E-01
Thyroid cancer	2D10	Thyroid	9.49E-01	6.35E-03	2.66E-02
Tibial muscular dystrophy	8C75	Muscle tissue	1.21E-04	-3.58E-01	-1.16E+00
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	4.48E-01	8.26E-02	3.48E-01
Type 2 diabetes	5A11	Liver tissue	9.25E-01	1.84E-02	9.69E-02
Ureter cancer	2C92	Urothelium	6.09E-01	-6.78E-02	-2.14E-01
Uterine cancer	2C78	Endometrium tissue	2.15E-08	1.84E-01	6.13E-01
Vitiligo	ED63.0	Skin	1.57E-02	-1.81E-01	-1.19E+00