Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DE4HCYL)

• DME Name: Thymidine phosphorylase (TYMP) DME Info
• Gene Name: TYMP

Molecule-Related Drug & Molecule List

4 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[1]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[2]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[3]
Trifluridine	DMG2YBD	Herpetic keratitis	1F00.10	Approved	[4]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Deoxythymidine	DMR90HY	Discovery agent	N.A.	Investigative	[5]

References

• [1] Induction of thymidine phosphorylase in both irradiated and shielded, contralateral human U87MG glioma xenografts: implications for a dual modality treatment using capecitabine and irradiation. Mol Cancer Ther. 2002 Oct;1(12):1139-45.
• [2] Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability. Mol Pharm. 2008 Sep-Oct;5(5):717-27.
• [3] 5-Fluorouracil pharmacogenomics: still rocking after all these years? Pharmacogenomics. 2011 Feb;12(2):251-65.
• [4] Phase I clinical study of three times a day oral administration of TAS-102 in patients with solid tumors. Cancer Invest. 2008 Oct;26(8):794-9.
• [5] Thymidine catabolism as a metabolic strategy for cancer survival. Cell Rep. 2017 May 16;19(7):1313-1321.