Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DERE4TU)

• DME Name: Monoamine oxidase type A (MAO-A) DME Info
• Gene Name: MAOA

Molecule-Related Drug & Molecule List

5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Almotriptan malate	DMFG5ST	N. A.	N. A.	Approved	[1]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[2]
Naratriptan	DMO50U2	Headache	8A80-8A84	Approved	[3]
Safinamide mesylate	DM0J2ZT	Parkinson disease	8A00.0	Approved	[4]
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[5]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzylamine	DMRM6ES	N. A.	N. A.	Investigative	[6]
PHENETHYLAMINE	DMX0G4F	Discovery agent	N.A.	Investigative	[6]
SEROTONIN	DMOFCRY	Discovery agent	N.A.	Investigative	[6]

References

• [1] Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clin Pharmacokinet. 2005;44(3):237-46.
• [2] Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study. J Neurooncol. 2019 Nov;145(2):287-294.
• [3] Migraine pharmacotherapy with oral triptans: a rational approach to clinical management. Expert Opin Pharmacother. 2000 Mar;1(3):391-404.
• [4] Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase. J Med Chem. 2007 Oct 4;50(20):4909-16.
• [5] Med-psych drug-drug interactions update. Psychosomatics. 2002 May;43(3):245-7.
• [6] Do monomeric vs dimeric forms of MAO-A make a difference? A direct comparison of the catalytic properties of rat and human MAO-A's. J Neural Transm (Vienna). 2007;114(6):721-4.