Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DESDN74)

• DME Name: Serum paraoxonase/arylesterase 1 (PON1) DME Info
• Gene Name: PON1

Molecule-Related Drug & Molecule List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Loteprednol Etabonate	DM8QTJI	Eye inflammation	9A02	Approved	[1]
Prulifloxacin	DMOK965	Urinary tract infection	GC08	Approved	[2]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RTR-003632	DM45NHF	N. A.	N. A.	Phase 2	[3]

6 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Coumaranone	DM7TCPG	N. A.	N. A.	Investigative	[3]
Dihydrocoumarin	DMGLX1R	N. A.	N. A.	Investigative	[3]
gamma-butyrolactone	DMDCZWY	Discovery agent	N.A.	Investigative	[3]
Gamma-thiobutyrolactone	DM83HUI	N. A.	N. A.	Investigative	[3]
Homogentisic acid	DMQD0YW	N. A.	N. A.	Investigative	[3]
PARAOXON	DMN4ZKC	Discovery agent	N.A.	Investigative	[3]

References

• [1] Identification of esterase involved in the metabolism of two corticosteroid soft drugs. Biochem Pharmacol. 2017 Mar 1;127:82-89.
• [2] Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62.
• [3] Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters. Drug Metab Dispos. 2000 Nov;28(11):1335-42.