Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DT06JWZ)

• DTP Name: Organic anion transporter 4 (SLC22A11) DTP Info
• Gene Name: OAT4

Molecule-Related Drug & Molecule List

9 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[1]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[2]
Estrone sulfate	DMVBIZL	Atrophic vaginitis	GA30.2	Approved	[3]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[4]
Levocetirizine	DMQYLGP	Allergic rhinitis	CA08.0	Approved	[5]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[7]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[8]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[9]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PGF2alpha	DM4XAU7	Solid tumour/cancer	2A00-2F9Z	Clinical trial	[2]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[10]
uric acid	DMA1MKT	Discovery agent	N.A.	Investigative	[11]

References

• [1] Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther. 2004 Mar;308(3):1021-9.
• [2] Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8.
• [3] Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4. J Pharm Pharmacol. 2006 Nov;58(11):1499-505.
• [4] The role of the intracellular glutamate gradient in driving organic anion transporter function.
• [5] Cellular Uptake of Levocetirizine by Organic Anion Transporter 4. J Pharm Sci. 2017 Sep;106(9):2895-2898.
• [6] Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71.
• [7] Inhibition of human organic anion transporter 3 mediated pravastatin transport by gemfibrozil and the metabolites in humans. Xenobiotica. 2007 Apr;37(4):416-26.
• [8] Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76.
• [9] Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24.
• [10] Role of human organic anion transporter 4 in the transport of ochratoxin A. Biochim Biophys Acta. 2002 Jun 12;1590(1-3):64-75.
• [11] Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers. Pharm Res. 2008 Mar;25(3):639-46.