Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DT48WEM)

• DTP Name: Proton-coupled amino acid transporter 1 (SLC36A1) DTP Info
• Gene Name: PAT1

Molecule-Related Drug & Molecule List

6 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aminolevulinic acid hci	DMS4BLQ	Acne vulgaris	ED80	Approved	[1]
Cycloserine	DMT1I52	Bacterial infection	1A00-1C4Z	Approved	[2]
Gaboxadol	DMI53FU	Insomnia	7A00-7A0Z	Approved	[3]
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[4]
L-Proline	DMKSTWR	Malnutrition	5B50-5B71	Approved	[5]
Vigabatrin	DMYT0OG	Alcohol dependence	6C40.2	Approved	[6]

References

• [1] Delta-aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1). Br J Pharmacol. 2010 Mar;159(6):1339-53.
• [2] Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1). J Cell Physiol. 2005 Aug;204(2):604-13.
• [3] Intestinal gaboxadol absorption via PAT1 (SLC36A1): modified absorption in vivo following co-administration of L-tryptophan. Br J Pharmacol. 2009 Aug;157(8):1380-9.
• [4] Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: characterization of conditions for affinity and transport experiments in Caco-2 cells. Eur J Pharm Sci. 2008 Sep 2;35(1-2):86-95.
• [5] PAT1 (SLC36A1) shows nuclear localization and affects growth of smooth muscle cells from rats. Am J Physiol Endocrinol Metab. 2014 Jan 1;306(1):E65-74.
• [6] Rectal absorption of vigabatrin, a substrate of the proton coupled amino acid transporter (PAT1, Slc36a1), in rats. Pharm Res. 2012 Apr;29(4):1134-42.