Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DTW78DQ)

• DTP Name: Equilibrative nucleoside transporter 2 (SLC29A2) DTP Info
• Gene Name: ENT2

Molecule-Related Drug & Molecule List

5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofarabine	DMCVJ86	Acute lymphoblastic leukaemia	2A85	Approved	[1]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[2]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[3]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[4]
Trifluridine	DMG2YBD	Herpetic keratitis	1F00.10	Approved	[5]

References

• [1] Cytarabine-resistant leukemia cells are moderately sensitive to clofarabine in vitro. Anticancer Res. 2014 Apr;34(4):1657-62.
• [2] FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia. Oncotarget. 2016 Aug 2;7(31):49786-49799.
• [3] Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278.
• [4] PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA2040)
• [5] Lonsurf, INN-trifluridine/tipiracil.