Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DTW7AE3)

• DTP Name: Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DTP Info
• Gene Name: ASCT2

Molecule-Related Drug & Molecule List

9 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[1]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[1]
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[2]
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[3]
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[4]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[5]
Valaciclovir	DMHKS94	Genital herpes	1A94	Approved	[6]
Valganciclovir	DMS2IUH	Virus infection	1A24-1D9Z	Approved	[7]
D-Serine	DM3YH4I	N. A.	N. A.	Phase 4	[8]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-threonine	DMFHTBX	Discovery agent	N.A.	Investigative	[8]

References

• [1] Amino Acid Transporter ATB0,+ as a delivery system for drugs and prodrugs. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Dec;5(4):357-64.
• [2] Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+). Am J Physiol Gastrointest Liver Physiol. 2007 Nov;293(5):G1046-53.
• [3] High-affinity glutamate transporter GLAST/EAAT1 regulates cell surface expression of glutamine/neutral amino acid transporter ASCT2 in human fetal astrocytes. Neurochem Int. 2006 May-Jun;48(6-7):611-5.
• [4] A polarized localization of amino acid/carnitine transporter B(0,+) (ATB(0,+)) in the blood-brain barrier. Biochem Biophys Res Commun. 2008 Nov 14;376(2):267-70.
• [5] Functional regulation of Na+-dependent neutral amino acid transporter ASCT2 by S-nitrosothiols and nitric oxide in Caco-2 cells. FEBS Lett. 2005 Apr 25;579(11):2499-506.
• [6] Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery. J Pharmacol Exp Ther. 2004 Mar;308(3):1138-47.
• [7] Transport of amino acid esters and the amino-acid-based prodrug valganciclovir by the amino acid transporter ATB(0,+). Pharm Res. 2004 Jul;21(7):1303-10.
• [8] D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551.