Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT08JVB)

• DTT Name: G-protein coupled receptor 120 (GPR120) DTT Info
• Gene Name: FFAR4

Molecule-Related Drug & Molecule List

6 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
alpha-linolenic acid	DMY64HE	Discovery agent	N.A.	Investigative	[1]
grifolic acid	DMGTRZE	Discovery agent	N.A.	Investigative	[2]
GW9508	DMVKZ5I	Discovery agent	N.A.	Investigative	[3]
NCG21	DMMRWJG	Discovery agent	N.A.	Investigative	[4]
PMID24997608CA	DML0PFU	Discovery agent	N.A.	Investigative	[5]
TUG-891	DMJRGZT	Discovery agent	N.A.	Investigative	[6]

References

• [1] Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):515-22.
• [2] Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch Pharmacol. 2009 Sep;380(3):247-55.
• [3] Free fatty acid receptors and drug discovery. Biol Pharm Bull. 2008 Oct;31(10):1847-51.
• [4] Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists. J Med Chem. 2008 Dec 11;51(23):7640-4.
• [5] A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med. 2014 Aug;20(8):942-7.
• [6] Discovery of a potent and selective GPR120 agonist. J Med Chem. 2012 May 10;55(9):4511-5.