Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT2AST1)

DTT Name	Macrophage migration inhibitory factor (MIF) DTT Info
Gene Name	MIF

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Preclinical Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[1]
Anti-MIF antibodies	DM8EKSV	Autoimmune diabetes	5A10	Phase 4	[2]
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1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISO-1	DMDB7KU	N. A.	N. A.	Phase 1	[3]
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1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
COR100140	DMN0GTR	Inflammation	1A00-CA43.1	Preclinical	[4]
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6 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME	DM7WPGN	Discovery agent	N.A.	Investigative	[5]
4-hydroxyphenylpyruvic acid	DM0564K	Discovery agent	N.A.	Investigative	[5]
6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE	DMPSOIF	Discovery agent	N.A.	Investigative	[5]
AVP-13546	DMDTONZ	Autoimmune disease	4A40-4A45	Investigative	[6]
AVP-13748	DMBNDYK	Autoimmune disease	4A40-4A45	Investigative	[6]
NAPQI	DM8F5LR	Autoimmune disease	4A40-4A45	Investigative	[6]
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⏷ Show the Full List of 6 Investigative Drug(s)

Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Neutralization of Macrophage Migration Inhibitory Factor (MIF) by Fully Human Antibodies Correlates with Their Specificity for the beta-Sheet Structure of MIF. J Biol Chem. 2012 March 2; 287(10): 7446-7455.
3	The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277(28):24976-82.
4	Cortical Pty Ltd Presents MIF Antagonist Data at World Congress on Inflammation. Cortical Pty Ltd. 2005.
5	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
6	MIF in autoimmunity and novel therapeutic approaches. Autoimmun Rev. 2009 Jan;8(3):244-9.