Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT2T5M0)

• DTT Name: Calcium-activated potassium channel KCa2.2 (KCNN2) DTT Info
• Gene Name: KCNN2

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
dequalinium	DMXM19W	Myelopathy	8B42	Clinical trial	[1]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
zoxazolamine	DM70TKB	Multiple myeloma	2A83	Terminated	[2]

7 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
apamin	DMYNBK5	Discovery agent	N.A.	Investigative	[3]
CyPPA	DM64L9I	Discovery agent	N.A.	Investigative	[4]
DC-EBIO	DM2T5OV	Discovery agent	N.A.	Investigative	[5]
EBIO	DMPKI0N	Discovery agent	N.A.	Investigative	[6]
UCL1684	DMZNJFU	Discovery agent	N.A.	Investigative	[7]
UCL1848	DM2CN0A	Discovery agent	N.A.	Investigative	[8]
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[6]

References

• [1] Block of rat brain recombinant SK channels by tricyclic antidepressants and related compounds. Eur J Pharmacol. 2000 Jul 28;401(1):1-7.
• [2] Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds. J Pharmacol Exp Ther. 2001 Mar;296(3):683-9.
• [3] SK2 encodes the apamin-sensitive Ca(2+)-activated K(+) channels in the human leukemic T cell line, Jurkat. FEBS Lett. 2000 Mar 10;469(2-3):196-202.
• [4] Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br J Pharmacol. 2007 Jul;151(5):655-65.
• [5] Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of ... J Biol Chem. 2005 Dec 16;280(50):41404-11.
• [6] Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol. 2010 Jul;91(3):242-55.
• [7] Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. Br J Pharmacol. 2000 Mar;129(5):991-9.
• [8] Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels. J Biol Chem. 2001 Apr 13;276(15):12249-56.