Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT3KBZY)

DTT Name	G-protein coupled receptor 54 (KISS1R) DTT Info
Gene Name	KISS1R

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TAK-683	DMRD8HK	Prostate cancer	2C82.0	Discontinued in Phase 1	[1]
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2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
4-fluorobenzoyl-Phe-Gly-Leu-Arg-Trp-NH2	DMWD42N	Discovery agent	N.A.	Investigative	[2]
kisspeptin-10	DMDL21W	Discovery agent	N.A.	Investigative	[3]
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Molecule Interaction Atlas

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References

1	Clinical pipeline report, company report or official report of Takeda (2009).
2	Development of novel G-protein-coupled receptor 54 agonists with resistance to degradation by matrix metalloproteinase. J Med Chem. 2008 Dec 11;51(23):7645-9.
3	The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem. 2001 Sep 14;276(37):34631-6.