Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT6PEUO)

• DTT Name: Retinoic acid receptor RXR-alpha (RXRA) DTT Info
• Gene Name: RXRA

Molecule-Related Drug & Molecule List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[1]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[2]

10 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(5BETA)-PREGNANE-3,20-DIONE	DMVQ6RN	Discovery agent	N.A.	Investigative	[3]
2-chloro-5-nitro-N-phenylbenzamide	DMUGQIV	Discovery agent	N.A.	Investigative	[3]
AGN-34	DM5ECDM	Discovery agent	N.A.	Investigative	[4]
CD3254	DM38MU1	Discovery agent	N.A.	Investigative	[5]
LG100754	DMEK4FY	Discovery agent	N.A.	Investigative	[6]
methoprene acid	DM58A0W	Discovery agent	N.A.	Investigative	[7]
PA451	DMTGZ3E	Discovery agent	N.A.	Investigative	[8]
phytanic acid	DMSZ1RB	Discovery agent	N.A.	Investigative	[9]
Tributylstannanyl	DMHN7CB	Discovery agent	N.A.	Investigative	[3]
UVI3003	DM95UI1	Discovery agent	N.A.	Investigative	[10]

References

• [1] Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):30-4.
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [3] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [4] Farnesoid X receptor: from structure to potential clinical applications. J Med Chem. 2005 Aug 25;48(17):5383-403.
• [5] Co-regulator recruitment and the mechanism of retinoic acid receptor synergy. Nature. 2002 Jan 10;415(6868):187-92.
• [6] The rexinoid LG100754 is a novel RXR:PPARgamma agonist and decreases glucose levels in vivo. Mol Endocrinol. 2001 Aug;15(8):1360-9.
• [7] Activation of mammalian retinoid X receptors by the insect growth regulator methoprene. Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6157-60.
• [8] Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions. J Med Chem. 2002 Aug 1;45(16):3327-30.
• [9] Phytanic acid is a retinoid X receptor ligand. Eur J Biochem. 1996 Feb 15;236(1):328-33.
• [10] Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators thro... J Biol Chem. 2005 Jan 14;280(2):1625-33.