Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT7HC21)

• DTT Name: Membrane copper amine oxidase (AOC3) DTT Info
• Gene Name: AOC3

Molecule-Related Drug & Molecule List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[1]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[2]

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ASP8232	DMYK1JU	Diabetic macular edema	9B71.02	Phase 2	[3]
BTT-1023	DMIEPJG	Psoriasis vulgaris	EA90	Phase 2	[4]

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BI 1467335	DMTE3UV	Diabetic retinopathy	9B71.0	Discontinued in Phase 2	[5]
Vapaliximab	DM73EPK	Inflammation	1A00-CA43.1	Terminated	[6]

7 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
6-hydroxydopa quinone	DM7M58P	Discovery agent	N.A.	Investigative	[7]
FP-1102	DMGID4T	Vascular disease	BE2Z	Investigative	[8]
LJP-1207	DMJ108U	Cerebrovascular ischaemia	8B1Z	Investigative	[8]
PSX-4206	DMVJDCM	Pulmonary disease	1B10-1F85	Investigative	[8]
PXS-4159	DMHCEOU	Asthma	CA23	Investigative	[8]
RTU-1096	DMWVBD9	Atopic dermatitis	EA80	Investigative	[8]
Vapill	DM30E56	Diabetic complication	5A2Y	Investigative	[8]

References

• [1] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Preclinical evaluation of a radioiodinated fully human antibody for in vivo imaging of vascular adhesion protein-1-positive vasculature in inflammation. J Nucl Med. 2013 Aug;54(8):1315-9.
• [5] Clinical pipeline report, company report or official report of Boehringer Ingelheim.
• [6] Clinical pipeline report, company report or official report of Huginonline.
• [7] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [8] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2767).