Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT9RTBL)

• DTT Name: Aurora B messenger RNA (AURKB mRNA) DTT Info
• Gene Name: AURKB

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PHA-739358	DMGYBZI	Prostate cancer	2C82.0	Phase 2	[1]

21 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
4-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine	DM9MPHF	Discovery agent	N.A.	Investigative	[2]
6-bromoindirubin-3-oxime	DM12WYV	Discovery agent	N.A.	Investigative	[3]
7-bromoindirubin-3-oxime	DM07QD3	Discovery agent	N.A.	Investigative	[3]
7-chloroindirubin-3-oxime	DM28NAB	Discovery agent	N.A.	Investigative	[3]
7-fluoroindirubin-3-acetoxime	DM70I3V	Discovery agent	N.A.	Investigative	[3]
7-fluoroindirubin-3-oxime	DMQD34N	Discovery agent	N.A.	Investigative	[3]
7-iodoindirubin-3-oxime	DMNFI02	Discovery agent	N.A.	Investigative	[3]
CGP-57380	DMFPOUC	Discovery agent	N.A.	Investigative	[4]
HESPERADIN	DM2CK7B	Discovery agent	N.A.	Investigative	[5]
Indirubin-3'-monoxime	DMLRQH0	Discovery agent	N.A.	Investigative	[3]
Indirubin-3-acetoxime	DM3UR1E	Discovery agent	N.A.	Investigative	[3]
Indirubin-3-methoxime	DMZ5ODC	Discovery agent	N.A.	Investigative	[3]
ISIS 173813	DM8ITFJ	Discovery agent	N.A.	Investigative	[6]
ISIS 173831	DM9Y5NX	Discovery agent	N.A.	Investigative	[6]
ISIS 173840	DMIU0QJ	Discovery agent	N.A.	Investigative	[6]
ISIS 173848	DMSG1NI	Discovery agent	N.A.	Investigative	[6]
PMID16451062C46	DMT3RUE	Discovery agent	N.A.	Investigative	[5]
PMID20855207C25	DMNEB6J	Discovery agent	N.A.	Investigative	[7]
PMID21742770C1	DME3JMH	Discovery agent	N.A.	Investigative	[8]
quinazoline deriv. 1	DMJDU5S	Discovery agent	N.A.	Investigative	[9]
SU 6656	DMF1P6W	Discovery agent	N.A.	Investigative	[4]

References

• [1] Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition. J Med Chem. 2005 Apr 21;48(8):3080-4.
• [2] Discovery of a new series of Aurora inhibitors through truncation of GSK1070916. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2552-5.
• [3] An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37.
• [4] The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315.
• [5] Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors. J Med Chem. 2006 Feb 9;49(3):955-70.
• [6] US patent application no. 7,375,212, Modulation of Aurora B expression.
• [7] Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6739-43.
• [8] A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett. 2012 Dec 13;3(12):1034-1038.
• [9] A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8.