Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTBL49X)

• DTT Name: Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DTT Info
• Gene Name: Malaria LACZ

Molecule-Related Drug & Molecule List

3 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9200020, Table 3 compound 8	DMCLHX5	N. A.	N. A.	Patented	[1]
US9200020, Table 3, Compound 1B	DMEARS2	N. A.	N. A.	Patented	[1]
US9200020, Table 3, Compound 2B	DMXFB5Z	N. A.	N. A.	Patented	[1]

16 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3h-Pyrazolo[4,3-D]Pyrimidin-7-Ol	DMLB2W5	Discovery agent	N.A.	Investigative	[2]
5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine	DMX0EAK	Discovery agent	N.A.	Investigative	[2]
7-Hydroxy-Pyrazolo[4,3-D]Pyrimidine	DMV39XT	Discovery agent	N.A.	Investigative	[3]
9-Deazaguanine	DM68IPZ	Discovery agent	N.A.	Investigative	[2]
9-[2-(1-Phosphonobutan-2-yloxy)ethyl]guanine	DMOGD42	Discovery agent	N.A.	Investigative	[4]
9-[2-(1-Phosphonobutan-2-yloxy)ethyl]hypoxanthine	DMKHXT9	Discovery agent	N.A.	Investigative	[4]
9-[2-(1-Phosphonopropan-2-yloxy)ethyl]guanine	DMCXN6R	Discovery agent	N.A.	Investigative	[4]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[2]
Alpha-Phosphoribosylpyrophosphoric Acid	DMT6KI7	Discovery agent	N.A.	Investigative	[5]
Carboxylic PRPP	DMCTUR1	Discovery agent	N.A.	Investigative	[2]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[2]
Formycin B	DMHLYUM	Discovery agent	N.A.	Investigative	[2]
Guanosine-5',3'-Tetraphosphate	DMG2ZFV	Discovery agent	N.A.	Investigative	[2]
Guanosine-5'-Monophosphate	DM3SLZK	Discovery agent	N.A.	Investigative	[2]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[2]
Pyrophosphate 2-	DMZQ75M	Discovery agent	N.A.	Investigative	[5]

References

• [1] 6-oxopurine phosphoribosyltransferase inhibitors. US9200020.
• [2] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [3] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
• [4] Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum h... Bioorg Med Chem. 2009 Sep 1;17(17):6218-32.
• [5] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.