Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTCI43M)

• DTT Name: GABA(A) receptor (GABAR) DTT Info
• Gene Name: GABAR

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ganaxolone	DMXJMKF	Epileptic seizures	8A61-8A6Z	Approved	[1]

6 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
OV101	DMA6LR3	Angelman syndrome	LD90.0	Phase 3	[2]
PH94B NS	DMDC7OH	Social anxiety disorder	6B04	Phase 3	[3]
Padsevonil	DMRZ1F2	Epilepsy	8A60-8A68	Phase 2/3	[4]
BTD-001	DMS6ZA0	Narcolepsy	7A20	Phase 2	[5]
Evt201	DM8QXEY	Sleep-wake disorder	7A00-7B2Z	Phase 2	[6]
SAGE-324	DM5NC39	Essential tremor or related tremors	8A04.1	Phase 2	[7]

References

• [1] FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 215904.
• [2] Gaboxadol in Fragile X Syndrome: A 12-Week Randomized, Double-Blind, Parallel-Group, Phase 2a Study. Front Pharmacol. 2021 Oct 8;12:757825.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models. J Pharmacol Exp Ther. 2020 Jan;372(1):11-20.
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] The partial positive allosteric GABA(A) receptor modulator EVT 201 is efficacious and safe in the treatment of adult primary insomnia patients. Sleep Med. 2009 Sep;10(8):859-64.
• [7] Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.