Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTCTE1G)

• DTT Name: Interleukin-8 (IL8) DTT Info
• Gene Name: CXCL8

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1]

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ABX-IL8	DMCZFMS	Melanoma	2C30	Phase 2	[2]
BMS-986253	DM42B0C	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[3]
MDX-018	DML5FX2	Autoimmune diabetes	5A10	Phase 1	[4]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
R-ketoprofen	DMHSUQ1	N. A.	N. A.	Discontinued in Phase 2	[1]

5 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-(2-(2,5-dichlorophenylamino)phenyl)acetic acid	DM54M6C	Discovery agent	N.A.	Investigative	[1]
2-(2-(2-chlorophenoxy)phenyl)acetic acid	DMBP1TQ	Discovery agent	N.A.	Investigative	[1]
2-(2-(2-chlorophenylamino)phenyl)acetic acid	DMPLV3A	Discovery agent	N.A.	Investigative	[1]
2-(2-(2-fluorophenoxy)phenyl)acetic acid	DMDSUR2	Discovery agent	N.A.	Investigative	[1]
2-(2-(2-fluorophenylamino)phenyl)acetic acid	DMVQ68F	Discovery agent	N.A.	Investigative	[1]

References

• [1] Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30.
• [2] Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am J Pathol. 2002 Jul;161(1):125-34.
• [3] Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid tumors. J Immunother Cancer. 2019 Sep 5;7(1):240.
• [4] Company report (Genmab)