Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTDMBF5)

• DTT Name: Arachidonate 5-lipoxygenase activating protein (FLAP) DTT Info
• Gene Name: ALOX5AP

Molecule-Related Drug & Molecule List

6 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DG031	DMO3AJS	Asthma	CA23	Discontinued in Phase 3	[1]
AM103	DMAQNBW	Cardiovascular disease	BA00-BE2Z	Discontinued in Phase 2	[2]
GSK2190914	DMHZQ0T	Asthma	CA23	Discontinued in Phase 2	[3]
GSK2190915	DM89AV2	Asthma	CA23	Discontinued in Phase 2	[4]
AZD4769	DMA3OWI	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 1	[5]
A-93178	DM1KBAY	Allergy	4A80-4A85	Terminated	[6]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-671,480	DMP4QCJ	Discovery agent	N.A.	Investigative	[7]
L-689,037	DMCH3ZK	Discovery agent	N.A.	Investigative	[5]

References

• [1] BAY x 1005 attenuates atherosclerosis in apoE/LDLR - double knockout mice. J Physiol Pharmacol. 2007 Sep;58(3):583-8.
• [2] AM103 Experimental Treatment for Respiratory Diseases. Amira Pharmaceuticals/GSK. 2009.
• [3] FLAP inhibitors for the treatment of inflammatory diseases. Curr Opin Investig Drugs. 2009 Nov;10(11):1163-72.
• [4] Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
• [5] 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. Mol Pharmacol. 1992 Feb;41(2):267-72.
• [6] Characterization of A-93178, an iminoxy-quinoline inhibitor of leukotriene biosynthesis. Adv Exp Med Biol. 1997;433:91-4.
• [7] 5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors. Mol Pharmacol. 1991 Jul;40(1):22-7.