Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTEP6RV)

• DTT Name: Glutathione reductase (GR) DTT Info
• Gene Name: GSR

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oxidized glutathione	DM9EQC0	Breast cancer	2C60-2C65	Approved	[1]

5 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acyl oxymethyl acrylamide ester derivative 1	DMXTUE1	N. A.	N. A.	Patented	[2]
Golden phosphorous acetyletic compound 1	DMVAKUI	N. A.	N. A.	Patented	[2]
Golden phosphorous acetyletic compound 2	DMYJ15A	N. A.	N. A.	Patented	[2]
Terpyridineplatinum(II) complexe 3	DM54EFD	N. A.	N. A.	Patented	[2]
Terpyridineplatinum(II) complexe 4	DMOV86T	N. A.	N. A.	Patented	[2]

15 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1-(2'-chlorophenyl)penta-1,4-dien-3-one	DMKTZSY	Discovery agent	N.A.	Investigative	[3]
2,4,6 trinitrobenzene sulfonate 1,3-bis (2-chlorethyl)-1-nitrosourea	DMTA152	Discovery agent	N.A.	Investigative	[1]
3,6-Dihydroxy-Xanthene-9-Propionic Acid	DM7AORH	Discovery agent	N.A.	Investigative	[4]
3-(Prop-2-Ene-1-Sulfinyl)-Propene-1-Thiol	DMMOE40	Discovery agent	N.A.	Investigative	[4]
3-Sulfinoalanine	DMILTRN	N. A.	N. A.	Investigative	[4]
4-nitrobenzo[c][1,2,5]thiadiazole	DMKZJ1V	Discovery agent	N.A.	Investigative	[5]
Flavin-Adenine Dinucleotide	DM5S4GK	Discovery agent	N.A.	Investigative	[4]
Glutathionylspermidine Disulfide	DMPX7FR	Discovery agent	N.A.	Investigative	[4]
Meta-Nitro-Tyrosine	DMITMN9	Discovery agent	N.A.	Investigative	[4]
N-6060	DMDMI7P	Asthma	CA23	Investigative	[6]
N-6547	DM814EQ	Inflammatory bowel disease	DD72	Investigative	[6]
N-9xxx	DMML1J4	Vascular disease	BE2Z	Investigative	[6]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[4]
Trans-(1S(R),2S(R))-2-Hydroxycyclooctyl nitrate	DMYVJHN	Discovery agent	N.A.	Investigative	[7]
Trans-(R(S))-2-Hydroxy-1-phenylethyl nitrate	DMXC98D	Discovery agent	N.A.	Investigative	[7]

References

• [1] The purification and properties of glutathione reductase from the cestode Moniezia expansa. Int J Biochem Cell Biol. 1995 Apr;27(4):393-401.
• [2] Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556.
• [3] Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. J Med Chem. 2005 Nov 17;48(23):7400-10.
• [4] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [5] Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2283-92.
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2613).
• [7] In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3661-3.