Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTEUC8H)

• DTT Name: Vitamin K epoxide reductase complex 1 (VKORC1) DTT Info
• Gene Name: VKORC1

Molecule-Related Drug & Molecule List

5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acenocoumarol	DMH75KV	Thrombosis	DB61-GB90	Approved	[1]
Dicumarol	DMFQCB1	Bleeding disorder	GA20-GA21	Approved	[2]
Phenindione	DM2PYNR	Coagulation defect	3B10.0	Approved	[3]
Phenprocoumon	DMDO279	Myocardial infarction	BA41-BA43	Approved	[3]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[3]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tecarfarin	DMTCR2O	Cerebrovascular ischaemia	8B1Z	Phase 3	[4]

References

• [1] Evaluation of a reverse-hybridization StripAssay for the detection of genetic polymorphisms leading to acenocoumarol sensitivity. Mol Biol Rep. 2010 Apr;37(4):1693-7.
• [2] Vitamin K antagonism of coumarin intoxication in the rat. Thromb Haemost. 1986 Apr 30;55(2):235-9.
• [3] [Oral anticoagulation and pharmacogenetics: importance in the clinical setting]. Rev Med Suisse. 2007 Sep 12;3(124):2030, 2033-4, 2036.
• [4] Tecarfarin, a novel vitamin K reductase antagonist, is not affected by CYP2C9 and CYP3A4 inhibition following concomitant administration of fluconazole in healthy participants. J Clin Pharmacol. 2011Apr;51(4):561-74.