Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTG0MQD)

• DTT Name: Inflammation-related GPCR EX33 (GPR84) DTT Info
• Gene Name: GPR84

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PBI-4050	DMPXK27	Idiopathic pulmonary fibrosis	CB03.4	Phase 2	[1]
SHR0534	DMGFTAI	Type 2 diabetes	5A11	Phase 1	[2]

6 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-hydroxy capric acid	DMJAN52	Discovery agent	N.A.	Investigative	[3]
2-hydroxylauric acid	DMCNW3M	Discovery agent	N.A.	Investigative	[3]
3-hydroxy capric acid	DMC70P1	Discovery agent	N.A.	Investigative	[3]
3-hydroxylauric acid	DMNMB6V	Discovery agent	N.A.	Investigative	[3]
6-n-octylaminouracil	DMXJFCQ	Discovery agent	N.A.	Investigative	[3]
undecanoic acid	DMFOIPL	Discovery agent	N.A.	Investigative	[4]

References

• [1] Phase 2 clinical trial of PBI-4050 in patients with idiopathic pulmonary fibrosis. Eur Respir J. 2019 Mar 18;53(3):1800663.
• [2] Targeting metabolic dysregulation for fibrosis therapy. Nat Rev Drug Discov. 2020 Jan;19(1):57-75.
• [3] Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288(15):10684-91.
• [4] Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84. J Biol Chem. 2006 Nov 10;281(45):34457-64.