Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTG140O)

• DTT Name: Inward rectifier potassium channel Kir1.2 (KCNJ10) DTT Info
• Gene Name: KCNJ10

Molecule-Related Drug & Molecule List

7 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chlorpropamide	DMPHZQE	Non-insulin dependent diabetes	5A11	Approved	[1]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[2]
Gliquidone	DMB0EUX	Diabetic complication	5A2Y	Approved	[3]
Glisoxepide	DMJPR2B	Non-insulin dependent diabetes	5A11	Approved	[4]
Glycodiazine	DM1WL9O	Diabetic complication	5A2Y	Approved	[5]
Mitiglinide	DMP8HEL	Diabetic complication	5A2Y	Approved	[6]
Tolazamide	DMIHRNA	Diabetic complication	5A2Y	Approved	[7]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfonylthioureas	DMBG0H1	Discovery agent	N.A.	Investigative	[8]

References

• [1] Effect of the chlorpropamide and fructose-1,6-bisphosphate of soluble TNF receptor II levels. Pharmacol Res. 2004 May;49(5):449-53.
• [2] Triggering and amplification of insulin secretion by dimethyl alpha-ketoglutarate, a membrane permeable alpha-ketoglutarate analogue. Eur J Pharmacol. 2009 Apr 1;607(1-3):41-6.
• [3] Hydroxyl-substituted sulfonylureas as potent inhibitors of specific [3H]glyburide binding to rat brain synaptosomes. Bioorg Med Chem. 2003 May 1;11(9):2099-113.
• [4] Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection. J Pharmacol Exp Ther. 2006 Jan;316(1):182-8.
• [5] Coupling between proximal tubular transport processes. Studies with ouabain, SITS and HCO3-free solutions. Pflugers Arch. 1977 Apr 25;368(3):245-52.
• [6] Carboxyl-glucuronidation of mitiglinide by human UDP-glucuronosyltransferases. Biochem Pharmacol. 2007 Jun 1;73(11):1842-51.
• [7] Inhibition of ATP-activated potassium channels exerts pressor effects and improves survival in a rat model of severe hemorrhagic shock. Shock. 1996 Jun;5(6):391-4.
• [8] Cardioselective K(ATP) channel blockers derived from a new series of m-anisamidoethylbenzenesulfonylthioureas. J Med Chem. 2001 Mar 29;44(7):1085-98.