Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTGKF90)

• DTT Name: Bone morphogenetic protein receptor (BMPR2) DTT Info
• Gene Name: BMPR2

Molecule-Related Drug & Molecule List

9 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AA-123	DMW73A8	Prostate cancer	2C82.0	Investigative	[1]
AA-166	DM2BMAZ	Articular cartilage disorder	FA34.Y	Investigative	[1]
AA-184	DMCN4ZD	Kidney injury	NB92.0	Investigative	[1]
AA-204	DMBGTX9	Kidney disease	GC2Z	Investigative	[1]
LDN-214117	DM57Z8J	Discovery agent	N.A.	Investigative	[2]
ML347	DMR8N36	Discovery agent	N.A.	Investigative	[3]
PMID23639540C13a	DMLXOAQ	Discovery agent	N.A.	Investigative	[3]
PMID23639540C13d	DMSTQGH	Discovery agent	N.A.	Investigative	[3]
PMID23639540C13r	DMHBZ0N	Discovery agent	N.A.	Investigative	[3]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1794).
• [2] Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014 Oct 9;57(19):7900-15.
• [3] Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.