Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTGSEFH)

• DTT Name: Sodium/hydrogen exchanger 1 (SLC9A1) DTT Info
• Gene Name: SLC9A1

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zoniporide hydrochloride	DM8L7JD	Angina pectoris	BA40	Phase 3	[1]

3 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CARIPORIDE	DMV2DY3	Angina pectoris	BA40	Discontinued in Phase 2	[2]
ENIPORIDE	DME7OCX	Cardiac arrhythmias	BC9Z	Discontinued in Phase 2	[3]
HOE-694	DML0B97	Heart arrhythmia	BC65	Terminated	[4]

16 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
5'-(N-ethyl-N-isopropyl)amiloride	DM3TPMO	Discovery agent	N.A.	Investigative	[5]
BIIB-513	DML4DQ3	Myocardial infarction	BA41-BA43	Investigative	[6]
Homoserine Lactone	DMTKN4A	Discovery agent	N.A.	Investigative	[7]
N-(3-Methanesulfonyl-4-methoxy-benzoyl)-guanidine	DM0H8CK	Discovery agent	N.A.	Investigative	[4]
N-(3-Methanesulfonyl-4-methyl-benzoyl)-guanidine	DMSVQJP	Discovery agent	N.A.	Investigative	[4]
N-(4-Bromo-3-methanesulfonyl-benzoyl)-guanidine	DMC28SN	Discovery agent	N.A.	Investigative	[4]
N-(4-Chloro-3-methanesulfonyl-benzoyl)-guanidine	DMFG6MU	Discovery agent	N.A.	Investigative	[4]
N-(4-Cyano-3-methanesulfonyl-benzoyl)-guanidine	DMGI9EA	Discovery agent	N.A.	Investigative	[4]
N-(5-m-Tolyl-furan-2-carbonyl)-guanidine	DMS2X69	Discovery agent	N.A.	Investigative	[8]
N-(5-Methanesulfonyl-2-methyl-benzoyl)-guanidine	DM91463	Discovery agent	N.A.	Investigative	[4]
N-(5-o-Tolyl-furan-2-carbonyl)-guanidine	DMFNZSL	Discovery agent	N.A.	Investigative	[8]
N-(5-Phenyl-furan-2-carbonyl)-guanidine	DMNU68D	Discovery agent	N.A.	Investigative	[8]
N-[2-(1H-benzoimidazol-2-yl)-benzoyl]-guanidine	DMI9GQV	Discovery agent	N.A.	Investigative	[9]
N-[4-(1H-benzoimidazol-2-yl)-benzoyl]-guanidine	DMT6LX9	Discovery agent	N.A.	Investigative	[9]
N-[5-(2-Ethyl-phenyl)-furan-2-carbonyl]-guanidine	DMP5A8K	Discovery agent	N.A.	Investigative	[8]
N-[5-(2-Nitro-phenyl)-furan-2-carbonyl]-guanidine	DMZ9V18	Discovery agent	N.A.	Investigative	[8]

References

• [1] Zoniporde: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1). Cardiovasc Drug Rev. 2003 Spring;21(1):17-32.
• [2] Synthesis and bioactivity of substituted indan-1-ylideneaminoguanidine derivatives. Eur J Med Chem. 2009 Sep;44(9):3771-6.
• [3] Bicyclic acylguanidine Na+/H+ antiporter inhibitors. J Med Chem. 1998 Sep 10;41(19):3736-47.
• [4] (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34.
• [5] NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous ... J Biol Chem. 2007 Jul 6;282(27):19716-27.
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 948).
• [7] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [8] (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J Med Chem. 2005 Apr 21;48(8):2882-91.
• [9] Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na+/H+ exchanger inhibitors, synthesis and protection against ischemic-... Bioorg Med Chem Lett. 2007 May 1;17(9):2430-3.