Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTGV6LY)

• DTT Name: Nuclear receptor ROR-gamma (RORG) DTT Info
• Gene Name: RORC

Molecule-Related Drug & Molecule List

10 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK2981278	DM25YLM	Plaque psoriasis	EA90.0	Phase 2	[1]
LYC-55716	DMV8WU9	Non-small-cell lung cancer	2C25.Y	Phase 2	[2]
VTP-43742	DMCA8G1	Psoriasis vulgaris	EA90	Phase 2	[1]
ESR0114	DMUNM4D	Plaque psoriasis	EA90.0	Phase 1/2	[3]
ARN-6039	DM4D85V	Multiple sclerosis	8A40	Phase 1	[4]
AZD0284	DMHBEKM	Plaque psoriasis	EA90.0	Phase 1	[3]
BBI-6000	DMTG9WM	Psoriasis vulgaris	EA90	Phase 1	[3]
JNJ-3534	DM49VWQ	Psoriasis vulgaris	EA90	Phase 1	[3]
JTE-451	DM01JU8	Plaque psoriasis	EA90.0	Phase 1	[3]
TAK-828	DMW43DL	Crohn disease	DD70	Phase 1	[1]

5 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ML209	DMV2F84	Autoimmune disease	4A40-4A45	Preclinical	[5]
Nobiletin	DM7R3B6	Atherosclerosis	BD40	Preclinical	[6]
SR1078	DM7MDZE	Liver cancer	2C12	Preclinical	[7]
SR1555	DMZV9JX	Rheumatoid arthritis	FA20	Preclinical	[8]
SR2211	DMWCBG8	Autoimmune disease	4A40-4A45	Preclinical	[8]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
25-hydroxycholesterol	DMCHAQ7	Discovery agent	N.A.	Investigative	[9]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] ROR nuclear receptors: structures, related diseases, and drug discovery. Acta Pharmacol Sin. 2015 Jan;36(1):71-87.
• [6] The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome. Cell Metab. 2016 Apr 12;23(4):610-21.
• [7] Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORalpha and ROR. ACS Chem Biol. 2010 Nov 19;5(11):1029-34.
• [8] Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307.
• [9] Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. Mol Endocrinol. 2010 May;24(5):923-9.