Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTHIZP9)

• DTT Name: Integrin alpha-5 (ITGA5) DTT Info
• Gene Name: ITGA5

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
JSM 6427	DM4QIOH	Macular degeneration	9B78.3	Phase 1	[1]

4 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GW-559090	DM1FIN9	Allergic rhinitis	CA08.0	Discontinued in Phase 2	[2]
DW-908e	DMXJ54Z	Allergy	4A80-4A85	Discontinued in Phase 1	[3]
TR-14531	DMH5SA6	Asthma	CA23	Discontinued in Phase 1	[4]
ZD-7349	DM1EB6H	Multiple sclerosis	8A40	Discontinued in Phase 1	[5]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
C(-GRGDfL-)	DMTMJAI	Discovery agent	N.A.	Investigative	[6]

References

• [1] An alpha5beta1 integrin inhibitor attenuates glioma growth. Mol Cell Neurosci. 2008 Dec;39(4):579-85.
• [2] Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma. J Leukoc Biol. 2008 January; 83(1): 1-12.
• [3] WO patent application no. 2008,1439,28, Methods and compositions for treating skin conditions.
• [4] US patent application no. US2010278784 (A1), Methods and compositions for treating skin conditions.
• [5] Eosinophil adhesion to cholinergic nerves via ICAM-1 and VCAM-1 and associated eosinophil degranulation. Am J Physiol Lung Cell Mol Physiol. 2002 Jun;282(6):L1279-88.
• [6] Multiple N-methylation by a designed approach enhances receptor selectivity. J Med Chem. 2007 Nov 29;50(24):5878-81.