Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTJ2PTI)

• DTT Name: Tubulin beta-2 chain (TUBB2) DTT Info
• Gene Name: TUBB2A

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[1]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DOLASTATIN-10	DMDUV1S	Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]

11 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2'-amino-3,4,4',5-tetramethoxy-(Z)-stillbene	DMUYZA8	Discovery agent	N.A.	Investigative	[3]
2,3'-diamino-3,4,4',5-tetramethoxy-(Z)-stillbene	DM2UWDR	Discovery agent	N.A.	Investigative	[3]
2-amino-3,4',5-trimethoxy-(Z)-stillbene	DMMZ2LI	Discovery agent	N.A.	Investigative	[3]
3,4',5-trimethoxy-(Z)-stilbene	DMYHC3S	Discovery agent	N.A.	Investigative	[3]
3,4,4',5-tetramethoxy-(Z)-stilbene	DMSN814	Discovery agent	N.A.	Investigative	[3]
3-bromo-4,4',5-trimethoxy-(Z)-stilbene	DMPZ4M8	Discovery agent	N.A.	Investigative	[3]
6-ile-ustiloxin	DMQF8JG	Discovery agent	N.A.	Investigative	[2]
N-(4-(3-(pyridin-2-yl)acryloyl)phenyl)acetamide	DMRH987	Discovery agent	N.A.	Investigative	[4]
USTILOXIN A	DMZP32O	Discovery agent	N.A.	Investigative	[2]
Ustiloxin D	DMA8JH7	Discovery agent	N.A.	Investigative	[2]
Ustiloxin F	DMT1LS0	Discovery agent	N.A.	Investigative	[2]

References

• [1] Effect of the antitumor drug vinblastine on nuclear betaII-tubulin in cultured rat kidney mesangial cells. Invest New Drugs. 2003 Feb;21(1):15-20.
• [2] Total synthesis and biological evaluation of ustiloxin natural products and two analogs. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4804-7.
• [3] 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. J Med Chem. 2006 Oct 19;49(21):6412-5.
• [4] Design and biological evaluation of novel tubulin inhibitors as antimitotic agents using a pharmacophore binding model with tubulin. J Med Chem. 2006 Sep 21;49(19):5664-70.