Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTKFVXR)

• DTT Name: Renal carcinoma antigen NY-REN-64 (IRAK-4) DTT Info
• Gene Name: IRAK4

Molecule-Related Drug & Molecule List

6 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GS-5718	DMRKU0L	Rheumatoid arthritis	FA20	Phase 2	[1]
Zabedosertib	DMEZGWP	Atopic dermatitis	EA80	Phase 2	[2]
AZD6793	DM5GRZV	Inflammation	1A00-CA43.1	Phase 1	[3]
BAY1834845	DM8V62T	Psoriasis vulgaris	EA90	Phase 1	[4]
CA-4948	DMWV8C6	Lymphoma	2A80-2A86	Phase 1	[5]
SAR444656	DMIF2OL	Atopic dermatitis	EA80	Phase 1	[6]

21 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amidopyrazole derivative 1	DM5X92S	N. A.	N. A.	Patented	[7]
Amidopyrazole derivative 2	DMGO9WY	N. A.	N. A.	Patented	[7]
Amidopyrazole derivative 3	DMTHS3L	N. A.	N. A.	Patented	[7]
Amidopyrazole derivative 4	DMF6N7Z	N. A.	N. A.	Patented	[7]
Amidopyrazole derivative 5	DMJ37V2	N. A.	N. A.	Patented	[7]
Amidopyrazole derivative 6	DMJZ1IG	N. A.	N. A.	Patented	[7]
Diaminopyridine analog 4	DMPUH4Z	N. A.	N. A.	Patented	[7]
Diaminopyridine analog 5	DM5B0F3	N. A.	N. A.	Patented	[7]
Fused benzoheterocycle amide derivative 1	DMKLO2H	N. A.	N. A.	Patented	[7]
Fused benzoheterocycle amide derivative 2	DM9NMHS	N. A.	N. A.	Patented	[7]
Indazole amide derivative 1	DMKUT6S	N. A.	N. A.	Patented	[7]
Indazole amide derivative 2	DMRPT5O	N. A.	N. A.	Patented	[7]
Indazoletriazolephenyl derivative 1	DMHJDU6	N. A.	N. A.	Patented	[7]
Indazoletriazolephenyl derivative 2	DMWZLK6	N. A.	N. A.	Patented	[7]
Macrolactam derivative 1	DM0ON7S	N. A.	N. A.	Patented	[7]
Macrolactam derivative 2	DME72VA	N. A.	N. A.	Patented	[7]
Macrolactam derivative 3	DMFNGUV	N. A.	N. A.	Patented	[7]
Macrolactam derivative 4	DM5AXHF	N. A.	N. A.	Patented	[7]
Pyrazole N-1 aryl and heteroaryl derivative 1	DMVX7YT	N. A.	N. A.	Patented	[7]
Pyrazolopyrimidine and thienopyrimidine amide derivative 1	DM6TB4Z	N. A.	N. A.	Patented	[7]
Pyrazolopyrimidine and thienopyrimidine amide derivative 2	DMFUNH4	N. A.	N. A.	Patented	[7]

8 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IRAK-1/4 inhibitor	DMOQBGP	Discovery agent	N.A.	Investigative	[8]
IRAK4 inhibitor 4b	DMC80TA	Discovery agent	N.A.	Investigative	[9]
IRAK4 inhibitor rac-45	DM1XHNW	Discovery agent	N.A.	Investigative	[10]
ND-2110	DMMODRE	Discovery agent	N.A.	Investigative	[11]
ND-2158	DMH7GLE	Discovery agent	N.A.	Investigative	[11]
PF-05313261	DMOLI1E	Inflammation	1A00-CA43.1	Investigative	[12]
WO2012007375C1	DMOZATX	Discovery agent	N.A.	Investigative	[12]
WO2012007375C7	DMPI2MA	Discovery agent	N.A.	Investigative	[12]

References

• [1] IRAK4 degrader to take on innate immunity. Nat Biotechnol. 2020 Nov;38(11):1221-1223.
• [2] Oral IRAK4 inhibitor BAY-1834845 prevents acute respiratory distress syndrome. Biomed Pharmacother. 2022 Sep;153:113459.
• [3] Clinical pipeline report, company report or official report of AstraZeneca
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] Clinical pipeline report, company report or official report of Sanofi
• [7] Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32.
• [8] Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5.
• [9] IRAK-4 inhibitors. Part 1: a series of amides. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3211-4.
• [10] IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3656-60.
• [11] Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders. J Med Chem. 2015 Jan 8;58(1):96-110.
• [12] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2045).