Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTL7C8Q)

• DTT Name: Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DTT Info
• Gene Name: IMPDH1

Molecule-Related Drug & Molecule List

5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[1]
Merimepodib	DM0HS92	Breast cancer	2C60-2C65	Approved	[2]
Mizoribine	DMW6F0S	Transplant rejection	NE84	Approved	[2]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[3]
Tiazofurin	DM5JWV9	Solid tumour/cancer	2A00-2F9Z	Approved	[4]

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Viramidine	DMJFNR9	Hepatitis C virus infection	1E51.1	Phase 3	[5]
VX-944	DME321B	Solid tumour/cancer	2A00-2F9Z	Phase 2	[6]

57 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamide derivative 10	DM9O56W	N. A.	N. A.	Patented	[6]
Carbamide derivative 11	DMK7DJR	N. A.	N. A.	Patented	[6]
Carbamide derivative 4	DM5V2D9	N. A.	N. A.	Patented	[6]
Carbamide derivative 5	DM951HL	N. A.	N. A.	Patented	[6]
Carbamide derivative 6	DMORBE3	N. A.	N. A.	Patented	[6]
Carbamide derivative 7	DMWKXN4	N. A.	N. A.	Patented	[6]
Carbamide derivative 8	DMZ3FJO	N. A.	N. A.	Patented	[6]
Carbamide derivative 9	DMY06VC	N. A.	N. A.	Patented	[6]
Mycophenolic acid/nucleotide derivative 1	DMOZTUE	N. A.	N. A.	Patented	[6]
Mycophenolic acid/nucleotide derivative 10	DMHD8RK	N. A.	N. A.	Patented	[6]
Mycophenolic acid/nucleotide derivative 11	DMXWOAG	N. A.	N. A.	Patented	[6]
Mycophenolic acid/nucleotide derivative 12	DM47L9Q	N. A.	N. A.	Patented	[6]
Mycophenolic acid/nucleotide derivative 2	DMAT9NE	N. A.	N. A.	Patented	[6]
Mycophenolic acid/nucleotide derivative 3	DM5UX7B	N. A.	N. A.	Patented	[6]
Mycophenolic acid/nucleotide derivative 4	DMEHMKY	N. A.	N. A.	Patented	[6]
Mycophenolic acid/nucleotide derivative 5	DM74UP5	N. A.	N. A.	Patented	[6]
Mycophenolic acid/nucleotide derivative 6	DMGFORB	N. A.	N. A.	Patented	[6]
Mycophenolic acid/nucleotide derivative 7	DMC27TO	N. A.	N. A.	Patented	[6]
Mycophenolic acid/nucleotide derivative 8	DMWGIJS	N. A.	N. A.	Patented	[6]
Mycophenolic acid/nucleotide derivative 9	DMYQTLK	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-US20100022547C80	DMQW470	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-US20100022547C81	DMM9E1U	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-US20100022547C82	DM94MT3	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-US20100022547C83	DM18LO7	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-US20100022547C86	DMONEJ4	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-US20100022547C87	DM8E702	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-US20100022547C88	DMNUR8E	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-US20120264760C80	DM75QVW	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-US20120264760C81	DMH249S	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-US20120264760C82	DM18PRU	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-US20120264760C83	DMD7AU3	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-US20120264760C86	DMKFEO4	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-US20120264760C87	DM85XKT	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-US20120264760C88	DMIKRCM	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-US20128202889C90	DMEJ4LW	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-US20158969342C84	DM1QUN0	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-US20169447134C85	DMMYH82	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-WO2009018344C78	DMFORUW	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-WO2009018344C79	DM64QNL	N. A.	N. A.	Patented	[6]
Quinazolinone derivative 1	DMSU1PC	N. A.	N. A.	Patented	[6]
Quinazolinone derivative 2	DM0XVQY	N. A.	N. A.	Patented	[6]
Quinolone derivative 1	DME6P7T	N. A.	N. A.	Patented	[6]
Urea and carbamate bioisostere derivative 10	DMWNR8I	N. A.	N. A.	Patented	[6]
Urea and carbamate bioisostere derivative 11	DMAP6YS	N. A.	N. A.	Patented	[6]
Urea and carbamate bioisostere derivative 13	DM6BJEW	N. A.	N. A.	Patented	[6]
Urea and carbamate bioisostere derivative 14	DMDP09N	N. A.	N. A.	Patented	[6]
Urea and carbamate bioisostere derivative 15	DM3SQUD	N. A.	N. A.	Patented	[6]
Urea and carbamate bioisostere derivative 16	DMRLC4X	N. A.	N. A.	Patented	[6]
Urea and carbamate bioisostere derivative 18	DM7PSB1	N. A.	N. A.	Patented	[6]
Urea and carbamate bioisostere derivative 2	DMRTJSC	N. A.	N. A.	Patented	[6]
Urea and carbamate bioisostere derivative 3	DMPXVWE	N. A.	N. A.	Patented	[6]
Urea and carbamate bioisostere derivative 4	DM5GZNS	N. A.	N. A.	Patented	[6]
Urea and carbamate bioisostere derivative 5	DM02ZM4	N. A.	N. A.	Patented	[6]
Urea and carbamate bioisostere derivative 6	DMP29I0	N. A.	N. A.	Patented	[6]
Urea and carbamate bioisostere derivative 7	DM2GPLQ	N. A.	N. A.	Patented	[6]
Urea and carbamate bioisostere derivative 9	DMIYD41	N. A.	N. A.	Patented	[6]
VX-148	DML32R8	Psoriasis vulgaris	EA90	Patented	[7]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenacetin	DMRQAM0	Analgesia	MB40.8	Withdrawn from market	[8]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
6-Cl-IMP	DMNTDFV	Discovery agent	N.A.	Investigative	[9]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[10]
Selenazofurin	DMKSIVL	Discovery agent	N.A.	Investigative	[4]
TAD	DMCIEQO	Discovery agent	N.A.	Investigative	[11]

References

• [1] Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol. 2008 Aug;64(8):753-67.
• [2] VX-497: a novel, selective IMPDH inhibitor and immunosuppressive agent. J Pharm Sci. 2001 May;90(5):625-37.
• [3] Treating HCV with ribavirin analogues and ribavirin-like molecules. J Antimicrob Chemother. 2006 Jan;57(1):8-13.
• [4] In vitro and in vivo antiproliferative activity of IPCAR, a new pyrazole nucleoside analog. Anticancer Res. 1998 Jul-Aug;18(4A):2623-30.
• [5] Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25.
• [6] Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690.
• [7] Characterization of pharmacological efficacy of VX-148, a new, potent immunosuppressive inosine 5'-monophosphate dehydrogenase inhibitor. J Pharmacol Exp Ther. 2002 Sep;302(3):1272-7.
• [8] A potent "fat base" nucleotide inhibitor of IMP dehydrogenase. Biochemistry. 1998 Aug 25;37(34):11949-52.
• [9] Identification of the IMP binding site in the IMP dehydrogenase from Tritrichomonas foetus. Biochemistry. 1995 Oct 24;34(42):13889-94.
• [10] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [11] Crystal structure of a ternary complex of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: NAD+ orients the active site loop for catalysis. Biochemistry. 2002 Nov 5;41(44):13309-17.