Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTN12BZ)

• DTT Name: CTP synthase (CTPS1) DTT Info
• Gene Name: CTPS1

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclopentenylcytosine	DMAWVTX	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acivicin	DMPQZ80	N. A.	N. A.	Discontinued in Phase 3	[2]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-Methyl-2,4-Pentanediol	DMD45CU	Discovery agent	N.A.	Investigative	[3]
Carbodine	DMA3FZR	Discovery agent	N.A.	Investigative	[4]
Cyclopentylcytosine	DM4KZ1W	Discovery agent	N.A.	Investigative	[1]
Cylopentenyl cytosine	DMQWLIC	Discovery agent	N.A.	Investigative	[5]

References

• [1] Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 1993 Sep;22(1):45-75.
• [2] Synergistic effects with inhibitors of de novo pyrimidine synthesis, acivicin, and N-(phosphonacetyl)-L-aspartic acid. Cancer Res. 1981 Sep;41(9 Pt 1):3419-23.
• [3] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [4] Potent activity of 5-fluoro-2'-deoxyuridine and related compounds against thymidine kinase-deficient (TK-) herpes simplex virus: targeted at thymidylate synthase. Mol Pharmacol. 1987 Aug;32(1):286-92.
• [5] Comments on: cylopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: a promising target for chemotherapy. A.C. Verschuur et al. Eur J Cancer 2000, 36, 627-635. Eur J Cancer. 2001 Jan;37(2):290.