Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTNY2AP)

DTT Name	Iduronate 2-sulfatase (IDS) DTT Info
Gene Name	IDS

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Idursulfase	DM30SXV	Hunter syndrome	5C56.31	Approved	[1]
------------------------------------------------------------------------------------

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Recombinant human iduronate-2-sulfatase	DMOWQAF	Hunter syndrome	5C56.31	Phase 3	[2]
DNL310	DMO3QAZ	Mucopolysaccharidosis II	5C56.31	Phase 2/3	[3]
RGX-121	DMU3PD7	Mucopolysaccharidosis	5C56.3	Phase 1/2	[4]
SB-913	DM98YFK	Mucopolysaccharidosis	5C56.3	Phase 1/2	[5]
------------------------------------------------------------------------------------

Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
2	The effect of recombinant human iduronate-2-sulfatase (Idursulfase) on growth in young patients with mucopolysaccharidosis type II. PLoS One. 2014 Jan 13;9(1):e85074.
3	Clinical pipeline report, company report or official report of Denali
4	Clinical pipeline report, company report or official report of REGENXBIO.
5	ClinicalTrials.gov (NCT03041324) Ascending Dose Study of Genome Editing by the Zinc Finger Nuclease (ZFN) Therapeutic SB-913 in Subjects With MPS II. U.S. National Institutes of Health.